Conserved Protein Domain Family
ETS_PEA3_N
?
pfam04621: ETS_PEA3_N (this model, PSSM-Id:282476 is obsolete and has been replaced by 461371)
PEA3 subfamily ETS-domain transcription factor N terminal domain
The N terminus of the PEA3 transcription factors is implicated in transactivation and in inhibition of DNA binding. Transactivation is potentiated by activation of the Ras/MAP kinase and protein kinase A signalling cascades. The N terminal region contains conserved MAP kinase phosphorylation sites.
Links
?
Statistics
?
PSSM-Id: 282476
Aligned: 31 rows
Threshold Bit Score: 229.924
Created: 15-Jul-2015
Updated: 5-Aug-2015
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q9PUQ1         5 MDGYLDQQVPY----TLA---NRS---QGNGP-LNRLLMATKRKYMDA-ELpPQ-ESEDLFQDLSQLQETWLTE------ 65  zebrafish
XP_006636097   1 MDGFYDQQVPY----MIT---NNT---QGRKC-NERPVNDRKRKFINT-DL-AH-DSEELFQDLSQLQETWLAE------ 60  spotted gar
XP_004089616   1 MDGFYDQQVPY----MVT---NSQ---RGRNC-NEKPTNVRKRKFINR-DL-AH-DSEELFQDLSQLQETWLAE------ 60  northern white-...
XP_005157691   1 MDGLHDQQVPF----IKS---HNP---RGKTS-GTRPAKDRKRKFINS-DL-AL-DTEELFQDLSQLQETWLAE------ 60  zebrafish
XP_006532527   6 kGGYLDQRVPY----TFC---SKS---PGNGS-LGEALMVPQGKLMDPgSL-PPsDSEDLFQDLSHFQETWLAE------ 67  house mouse
XP_001362921   6 kGGYVDQQVPY----TFS---SKS---PGNGS-LSRALMVTLGKLMDPgSL-PPpESEDLFQDLSQFQETWLTE------ 67  gray short-tail...
XP_005394562   6 kGGSLDQQVPY----TAC---SKL---SGNGS-LREGLMVPQRKLMDPgSL-PPpDSEDLFQDLSHFQETWLAE------ 67  long-tailed chi...
XP_008270022   6 kGGYLDQQVPY----TLC---SKS---PGNGS-LQEALMVPQGKLMDPgSL-PPpDSEDLFQDLSHFQETWLAEdaa--a 71  rabbit
XP_002606237   6 rkeFYDQEVPY----MYPqsvPST---DREDD-TPPANDGQKRK-----EL--Q-DSEELFQDLSQLQEAWLAE------ 63  Florida lancelet
XP_785701     11 sDGFYDQQVPFldsqTVP---DVDevpDCETCpEGASCGKSKG------DL-DQ-DSKELFHDLDQLQEEWLADdfgygp 79  purple sea urchin

Q9PUQ1        66 -AQ-VP-------------------DsDEQFVP----DFHSE-NsVAFHSPP-VKIKKEPQS------PGSDPSQSCSHK 112 zebrafish
XP_006636097  61 -AQ-VP-------------------DnDEQFVP----DFQAE-N-LAFHGLP-LKIKKEPQS------PCSELSSTCTQE 106 spotted gar
XP_004089616  61 -AQ-VP-------------------DnDEQFVP----DYQAE-S-LAFHGLP-LKIKKEPHS------PCSEIGSACSQE 106 northern white-...
XP_005157691  61 -AQ-VP-------------------DnDEQFVP----DFQSE-N-LGLHGLQ-LRLKREPHS------PCADLGSACSQE 106 zebrafish
XP_006532527  68 -AQ-VP-------------------DsDEQFVP----DFHSE-N-LAFHSPT-TRIKKEPQS------PRTDPALSCSRK 113 house mouse
XP_001362921  68 -AQ-VP-------------------DsDEQFVP----DFHSE-N-LAFHSPT-TKIKKEPQS------PRADPTLSCSRK 113 gray short-tail...
XP_005394562  68 -AQ-VP-------------------DsDEQFVP----DFHSE-N-LAFHSPT-TRIKKEPQS------PRAEPALSCSRK 113 long-tailed chi...
XP_008270022  72 gAL-SPctspappqppllplptrrlL-DEN-VPctekELQSHrQ-VAFHSPT-TRIKKEPQS------PRTDPALSCSRK 140 rabbit
XP_002606237  64 -AScVE-------------------D-EEQFVP----DFQAE-N-IL--TAP-MKVKSEPRSldecprPCSHMVPPGEMS 113 Florida lancelet
XP_785701     80 eSE------------------------PEQYVP----DFQSE-N-L----PLsIKIKPEPrS------PGYH--KPCAHM 117 purple sea urchin

Q9PUQ1       113 QSF----------------SYPNGEQCLY---ASAYEQKRaavagAGGSK---S---S----CPA--------TP-MSPM 154 zebrafish
XP_006636097 107 PSF----------------KFSYGEKCLYn--VSAYDQKP-----QLGMK---P---Ssp-sTPCs-------TP-VSPL 148 spotted gar
XP_004089616 107 QPF----------------KFSYGEKCLYn--VSAYDQKP-----QVGMR---PsnpP----TPSs-------TP-VSPL 148 northern white-...
XP_005157691 107 RPF----------------RLHYGEKCLYn--ISAYEQKH-----PSGMK---A---SspvsTPCs-------TP-VSPG 149 zebrafish
XP_006532527 114 PPL----------------PYHHGEQCLYs---SAYDSPR-----QIAIK---S---P----APGa-------PG-QSPL 151 house mouse
XP_001362921 114 PPL----------------SYHHGEQCLYt---SAYDTPR-----QVAIK---S---P----THSa-------PG-QSPL 151 gray short-tail...
XP_005394562 114 PPP----------------PYHHGEQCLYs---SACAPPR-----QTAIK---S---P----APGa-------PG-QSPL 151 long-tailed chi...
XP_008270022 141 PPL----------------PYHHGEQCLYs---SAYDPPR-----QIAIK---S---P----APGa-------PG-QSPL 178 rabbit
XP_002606237 114 NPD----------------KFDFGEQLFMg--NPC--------------------------------------------D 131 Florida lancelet
XP_785701    118 KSpaastshrhfdfdkfeqKFAYGEQVLVdnpFSKLDGLSlvipaPSPSStddH---P----SPPgsacsdavAPqSSPV 190 purple sea urchin

Q9PUQ1       155 -QHySPK------------------------------------------------------------------------- 160 zebrafish
XP_006636097 149 hHG-SPN------------------------------------------------------------------------- 154 spotted gar
XP_004089616 149 hHAsPNS------------------------------------------------------------------------- 155 northern white-...
XP_005157691 150 qHVs-PT------------------------------------------------------------------------- 155 zebrafish
XP_006532527 152 qP------------------------------------------------------------------------------ 153 house mouse
XP_001362921 152 qH------------------------------------------------------------------------------ 153 gray short-tail...
XP_005394562 152 q------------------------------------------------------------------------------- 152 long-tailed chi...
XP_008270022 179 qP------------------------------------------------------------------------------ 180 rabbit
XP_002606237 132 pKLpPLP------------------------------------------------------------------------- 138 Florida lancelet
XP_785701    191 tKGnASStksttgnakgstksnssgmvdmaqramaspsidlnmnriikqehpgpsmcssscnksnndtnnngssissptt 270 purple sea urchin

Q9PUQ1       161 ----------PTVGTRQESGYm--NPPSSSQ------SHacHSHSYPM---NPs---sRFPSGSAEMCPPFA-------- 208 zebrafish
XP_006636097 155 ----------PAPTPKPDRTYp--AHLPPSQ------QM--PDTSFPM---DH-----RFRRQLSEPCRSFP-------- 198 spotted gar
XP_004089616 156 ----------T-HTPKPDRAFp--AHLPPSQ------SI--PDSSYPM---DH-----RFRRQLSEPCNSFP-------- 198 northern white-...
XP_005157691 156 ----------AAPTPKPERTY---PHLAPPQ------PL--PDSAYPI---DH-----RFRRQLSEPCHSFP-------- 198 zebrafish
XP_006532527 154 -------------FSRAEQQQsllRASSSSQ------SH--PGHGYLG---EHs---sVFQQPVD-MCHSFT-------- 197 house mouse
XP_001362921 154 -------------FPRAERSFl--RPPGAAP------SN--PSHGFMM---EPs---sIFQQPP-EICHSFP-------- 195 gray short-tail...
XP_005394562 153 ----------PFPRAEPRGLL---RSSGPSQ------PH--PGHGHLG---EHs---pVFQQPLDA-CHSFT-------- 196 long-tailed chi...
XP_008270022 181 -------------FPRTEQRSf-lRASGASQ------PH--PSHGYLG---EHstpssVFQQPLD-MCHSFT-------- 226 rabbit
XP_002606237 139 ----------PAHPPTPKQDG---MSYPPST------S----STGYPHppePP-----RYQRQLSEPAYRLA-------- 182 Florida lancelet
XP_785701    271 pqgpsmcqmvTFKEPLLpggs---gfgPSSNhfrahgPg--pGPGFFL---DK-----RFQRQTSEPCFGNLahpmgaag 337 purple sea urchin

Q9PUQ1       209 --SQGQALQR--IDPaHasggggggYHRQH----------SDPCL-PYpP--------QQTFKQEYMDPLYDRAA----H 261 zebrafish
XP_006636097 199 --TPSAMTRD--GRP-I--------YHRQM----------SEPSI-PF-P--------PQGFKQEFPDPVYEHNA----M 241 spotted gar
XP_004089616 199 --PLPTMPRE--GRP-M--------YQRQM----------SEPNI-PF-P--------PQGFKQEYHDPVYEHNT----M 241 northern white-...
XP_005157691 199 --SP-SMSRD--GRP-M--------YHRQM----------SEPSI-PF-P--------PQGFKQEYVDPLFEHPA----M 240 zebrafish
XP_006532527 198 --SPQGGGRE--PLPaP--------YQHQL----------SEPCP-PY-P--------QQNFKQEYHDPLYEQAG----Q 241 house mouse
XP_001362921 196 --SSQGGGRE--PPSaS--------YQPQL----------PEPCL-PY-P--------QQSFKREYHDPLYEQAG----- 238 gray short-tail...
XP_005394562 197 --PSQGGSGD--PLAaP--------YQHPL----------PEPCP-PY-P--------HQGFKQEYHDPLYEQAG----- 239 long-tailed chi...
XP_008270022 227 --SSQGGGRE--TLPaP--------YQHQL----------SEPCP-PY-P--------QQSFKQEYHDPLYEQAGqpavG 274 rabbit
XP_002606237 183 --DPHAFQRQv-SDP-M--------FQRQVpdhmhfqrsaSDTGF-QP-PrsegqspfPTNIKQEFPEPMYSRAM----A 244 Florida lancelet
XP_785701    338 nsAAESGGGGggGGPhP--------FQRQN----------SEPVFlPFkN--------RVGFNQ---------------- 375 purple sea urchin

Q9PUQ1       262 I----NGPQPQRFPPaHMMVKQEPTDYTYEP---DVPGCP-SMYHHNEGYSNPQHNS-E--G-------YMFENDSRVVP 323 zebrafish
XP_006636097 242 L----GTPVAQNYPP-AMIIKQEPRDFTYDS---EVPSCH-SIYMRQESFLAHSNRT-E--GciydkvpRHFYDDTCVVP 309 spotted gar
XP_004089616 242 V----GSAASQSFPP-PLMIKQEPRDFAYDS---EVPSCH-SIYMRQEGFLAHPSRT-E--GcmfekgpRQFYDDTCVVP 309 northern white-...
XP_005157691 241 M----GAPLPQPYTH-SMMIKQEPRDFTYDS---EVPSCH-SVYLRQEGYLAHSNRT-E--GcmfdkvaRHFYDDTCVVP 308 zebrafish
XP_006532527 242 PassqGGVSGHRYPGaGVVIKQERTDFAYDS---DVPGCA-SMYLHPEGFSGPSPGD-GvmGygyekslRPFPDDVCIVP 316 house mouse
XP_001362921 239 -----GGGGSARYPGaGVVIKQEQTDFAYDS---DVPGCQ-SMYLHAEGFPGPTPGE-GtmGygfekslRPFPEDVCVVP 308 gray short-tail...
XP_005394562 240 R----GGLRGHRYPGaGVVIKQEQTDFAYDA---DVPGCA-SMYLHPEGFSGPAAGD-RamGygyekalRPFPEDVCVVP 310 long-tailed chi...
XP_008270022 275 Q----GGVSGHRYPGaGVVIKQEQTDFAYDS---DVPGCA-SMYLHNEGFSGPSP------GygyekplRPFPDDVCVVP 340 rabbit
XP_002606237 245 P----PFPPCPP-------IKQEPRDMGYDGgqaEVPV-W-DPYQRRDSMYGPQAAAgE--GfltdsniRSFYDDSC-LP 308 Florida lancelet
XP_785701    376 ----------TRFR--ETIVKQEPVDYGYEA---EVPRSFgNGFPRQeMFMQRHCKEe---Ggqv-ecgRAFYDDAS-VP 435 purple sea urchin

Q9PUQ1       324 EKFEGEVKQEgG-SVFREGAPYQRRG 348 zebrafish
XP_006636097 310 EKFEGDIKQE-P-GLYREGPTYQRRG 333 spotted gar
XP_004089616 310 EKFDGDIKQE-P-GMYREGPTYQRRG 333 northern white-cheeked gibbon
XP_005157691 309 EKAEGDIKQE-A-GLYREGPTYQRRG 332 zebrafish
XP_006532527 317 EKFEGDIKQE-GiGAFREGPPYQRRG 341 house mouse
XP_001362921 309 EKFEGDIKQE-GlGTFREGPPYQRRG 333 gray short-tailed opossum
XP_005394562 311 ERLEGDIKQE-GlGAFREGPPYQRRG 335 long-tailed chinchilla
XP_008270022 341 EKFEGDMKQE-GvGAFREGPPYQRRG 365 rabbit
XP_002606237 309 DKLAEGMKPE----LYREAPTYQRRG 330 Florida lancelet
XP_785701    436 EKAQEQHNEPrH-EVVREGPLYHRRG 460 purple sea urchin
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap