Conserved Protein Domain Family
Nup84_Nup100
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pfam04121: Nup84_Nup100 (this model, PSSM-Id:282039 is obsolete and has been replaced by 461184)
Nuclear pore protein 84 / 107
Nup84p forms a complex with five proteins, of which Nup120p, Nup85p, Sec13p, and a Sec13p homologues. This Nup84p complex in conjunction with Sec13-type proteins is required for correct nuclear pore biogenesis.
Links
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Statistics
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PSSM-Id: 282039
Aligned: 111 rows
Threshold Bit Score: 479.436
Created: 11-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5RGI2       203 TWLLQQEMVTWRLITSLYRDRVqtv-------------------------leeD-IMMDIT---M-PSESE--KAVMEQF 250 zebrafish
Q6FR90        66 GKDWELEANYWSLFRQLIKFRYsd---------------------------------kHQQ---QsQVNCStrAAYEKEL 109 Candida glabrata
XP_003675058  65 nNDWEQEARLWHLLDLLMSFRTad------------------------------hdTDRIS---IeNYNSN--ALFEKQL 109 Naumovozyma cas...
XP_001645697  66 nsDLVLEANFWHLVEILLSFRTsq---------------------------efLdKESSIS---SkPYNSS--IIFEKEL 113 Vanderwaltozyma...
XP_003668611  86 YNDWELEARFWHLLDLLISYRVsdh-------------------------dmnDeNENENHanvVyPYNSS--AIFEKDL 138 Naumovozyma dai...
XP_003684943  83 ssDFELEAKLWHLTELILDFRMssd-------------------------ddnLdGVSNIK---AkPYNSN--IVYEKEC 132 Tetrapisispora ...
XP_011275819  65 YQNWELEAKLWHLVDLLISYRn-------------------------------SeKAEMVP---TyTFSSN--IVHEKNF 108 Wickerhamomyces...
XP_004179287  73 FEDWQLEAKFWHLLELLTSFRTsenynqiinelqsdssnsnmedervditmgsTnFEDRIE---TkPYNSS--AIFERDL 147 Tetrapisispora ...
XP_002554606  65 FENWELEAKLWHLIELLVNFRTadl-------------------------nidEdIEQLED---DsLG-------FTKSL 109 Lachancea therm...
XP_002493312  65 LENWILETKFWNLVEMLIKYRFfv---------------------------dfEkTNSDTD---VnPYRTD--LSVKEQI 112 Komagataella pa...

Q5RGI2       251 FQKDSMVRQSQLVVDWLESIAk---DDIGdFsdNIeyYAKS----VYWENTLHTLk--LrrnqssgglSR---P-LVTEL 317 zebrafish
Q6FR90       110 LQNNNDFYELWIIMVWLQDNLqtveRPENlp-------------tKKWNHTLLKqg-lQ-------------------SQ 156 Candida glabrata
XP_003675058 110 LQDDKKLYQIWIIMVWLQENMtiqeRPDNlP---------T----SKWTQTLISGnl--------------------eSA 156 Naumovozyma cas...
XP_001645697 114 LQKDKNLYQIWLIIVWIEGNFpfveKPSNiPs-------------SKWTNTLVt-------------------SgLMSS- 160 Vanderwaltozyma...
XP_003668611 139 LSKDHQLYQIWIIIVWLQENRtvgeRPTSlP---------T----SKWVNTLISGgglK-------------------SS 186 Naumovozyma dai...
XP_003684943 133 LENNKSLHEIWIIIYWLQSNLprveRPNDiP---------G----TKWNNTMVSGnl--------------------hSV 179 Tetrapisispora ...
XP_011275819 109 YTESDKLGEIWLLILWIQEGAlepeRPNLs----------T----SKWLNTQLSNtleN--------------------L 154 Wickerhamomyces...
XP_004179287 148 LQSNRELYEIWIIIVWLQSNRqqkeRPLNlPv-------------TKWSSSMISGtl--------------------kSS 194 Tetrapisispora ...
XP_002554606 110 LKKDRSLYEIWLIMLWIQSNIsvpaRPDGiA---------G----SKWSHSFMSGel--------------------kSC 156 Lachancea therm...
XP_002493312 113 ISANSNLKELMVIISWLTQNFnldlVDRDpFl-PD--SKDSelqaNKWFHTRIDIq------------SNedkPtLVRQL 177 Komagataella pa...

Q5RGI2       318 DPDAPIR--Q-KR--P-L-ADLDREDDSRLLKNLFNLIRAGMTDEAQRLCKRCGQAWRAATLEGWKLYHD-PNInggg-- 387 zebrafish
Q6FR90       157 DVDYPLR--D-SS--ViL-DEKDREQDRVIFKYIFQLLLRGKIEEALNECELSGNLTLSMIICGLQEYVN-PEIdfhl-- 227 Candida glabrata
XP_003675058 157 DLDYPLR--NvGV--T-I-EQKDKEQDHIFFQYIYHLLLAGKYEEAFEECKLSENLTLNMILCGIQEYVN-PAIdtqi-- 227 Naumovozyma cas...
XP_001645697 161 DLDYPLR--D-CS--VvI-NDKDKADDHVFYKYVYELLLCGNYDQIFEECKLSDNITLNMIMCGMQEYVD-PSIdvql-- 231 Vanderwaltozyma...
XP_003668611 187 DLDARLR--D-PAvvK-L-HEKDIQDDQMFFKYIYDLLLSGNYDELFDECRLSENLTFSMILCGMQEYVN-PKIdtqv-- 258 Naumovozyma dai...
XP_003684943 180 DLDSPLR--D-AN--V-IiDAKDKVQDHVFYKYIFDLLLCGEYERVFEECKLSDNITMYMILCGMQEYVD-PVVdsql-- 250 Tetrapisispora ...
XP_011275819 155 DSDASLR--L-NK--P-I-NPKDQEEDTVFFKYVFELMLAGRFDEAQAECTRTNNWTLRMILAGLNEFLD-PVVdkqm-- 224 Wickerhamomyces...
XP_004179287 195 DLDEPLR--N-PE--SgI-DIKDRLDDSIFYKYIFELLLSGKIDLAIEECNLSENITLAMILCGLKEYSN-PAIdfpn-- 265 Tetrapisispora ...
XP_002554606 157 DLDYPLR--EsDC--K-I-DNRDKQSDHAFYKYIYELLLAGRYDDARKECELSDNTTLALILCGLDNYVGfSVGepan-- 228 Lachancea therm...
XP_002493312 178 DADAPLRgkD-NN--R-L-NEKDVQYDSNFFERVFRLLLEGNIDEISQLCKETNNWSFALVLRGLKDFID-PELngsfsr 251 Komagataella pa...

Q5RGI2       388 ----------gelQPVEGNPHRSVWKVCCWRMAEEEQFNKYERAIYAALSGNL---------K-------QLLPV--CE- 438 zebrafish
Q6FR90       228 ---------knefDFQQGIKKHSLWRRTVYGISQNSKLDLYERAIYSLLAGVS---------P-------SE-EVmsIC- 280 Candida glabrata
XP_003675058 228 ---------anefEMQQGVKKHALWRRAVYNLSQCPDLNPYERAIYNYLSGTI---------P-------DT-GI--DA- 278 Naumovozyma cas...
XP_001645697 232 ---------kdefEVQQGVKKHSLWRRAVYSLSQNDKLDKYERAIYSYLAGDI---------P-------NDEVL--QTl 284 Vanderwaltozyma...
XP_003668611 259 ---------dnefDSQQGVKKHALWRRAVFALSKSSNIGYYERAIYQYLAGVIlednnagkdQ-------AIL-----M- 316 Naumovozyma dai...
XP_003684943 251 ---------rngfEKQQGVKKRILWRRAVYNLSLNDSLDSYERAIYSYLAGDF---------P-------NDEEVrsNL- 304 Tetrapisispora ...
XP_011275819 225 ---------seldEKTQGIKRKALWRRTVYLLSKNEGLNEYERAIYGYLIGDL---------S-------P-LKL--TN- 275 Wickerhamomyces...
XP_004179287 266 ---------tsgsIKQSGIQKHALWRRTVFSLSTNKSLDKYERIIYNYLSGTL---------PdfdesvfTEILE--EL- 324 Tetrapisispora ...
XP_002554606 229 ----------ddlQPQENIKGKALWRRAVHSLSLQQELDEYERAIYSYLAGDV------------------FEGI--DT- 277 Lachancea therm...
XP_002493312 252 dddedigvnsqetKRCIGIKNRKLWRKTVYQLSLNEQLTDKERGVYGYMCGSH---------E-------VPVKL--TN- 312 Komagataella pa...

Q5RGI2       439 SWEDTVWAYFRVMVDTLVEQEICSSglgseeleelpRD---FLETN-----------WTLEKVFEEIQATESKRVLDATK 504 zebrafish
Q6FR90       281 NWEELLIFFINQKLQTDIENEMIR------------AG---FVTDEeiqlyipssteSL-SSILNDLSNL----KPEESS 340 Candida glabrata
XP_003675058 279 NWDSDFLLQLNQILQIEIENYLLKNgkina--eeliTP---LPMYA-----------KSLDKILNSLS----ERYPMESE 338 Naumovozyma cas...
XP_001645697 285 NWDSELLVYLNQILKIEVENYLLQNgkvnn--deliLS---LPSNT-----------MDLQSILNLLSAK----HPEESE 344 Vanderwaltozyma...
XP_003668611 317 DWETEFLLYLNQIFQIEVENYLLQNnkfds--eelvLQ---LPSKS-----------ISLPDILNLLASK----YPTESE 376 Naumovozyma dai...
XP_003684943 305 SWAKELLIYLNQIMNIEIENYLMKEekvtk--deliLA---LPSKS-----------MDLQSILNLLSNK----YSTEAA 364 Tetrapisispora ...
XP_011275819 276 TWDSQLLVYLNHILTSEIESTLIDNgkinn--edliLT---IPRSE-----------LSVQDVLNSVSQ----RLKDESE 335 Wickerhamomyces...
XP_004179287 325 DWESHLILYLNQNLQISVENYLISNskidt--teliLA---LPNIP-----------IPINDILNLISL----RHPKDSE 384 Tetrapisispora ...
XP_002554606 278 NWDIDLLLYLNQALQISLENHLLEDklvds--keiiLP---MASDP-----------VPLQSVLDIIARK----HVAEGE 337 Lachancea therm...
XP_002493312 313 SWDRQLLIYCNNILQHDMEIELERVtrplt--gsadLQlplPPKKH-----------RDLNDTLNALASSNNPSIREQSQ 379 Komagataella pa...

Q5RGI2       505 EHYHVIQKFVILGDLDGLLEEFSDWLG------R---N---T---PL------P------AHLLRFMSHLVLFYRSLGMq 557 zebrafish
Q6FR90       341 HPLRTLIASIILGTTDSIVHSSVLQLF------Daik------nseQeneifnE------PYLLRVMTHTAIMFKII--- 399 Candida glabrata
XP_003675058 339 SPMKVLMGAIILDTLPSVLHSSVEMLL------DiikG---K---ES------SndlldePYLLRVVTHLSIF---IDVi 397 Naumovozyma cas...
XP_001645697 345 HPIRVLIGSVMLNTIPSVLHSSVSMLM------N---V---VtgiEN------DndifgePYLLRVVTHMTIFLEILNp- 405 Vanderwaltozyma...
XP_003668611 377 SPIRVLIGAIILDKLPSLVHSSVEMLQ------DlvaG---E---EN------NndlldePYLLRVMTHLVIFLDFV--- 435 Naumovozyma dai...
XP_003684943 365 HPLRVLIGAVILDTLPSVLHSSVSMLM------D---VvngN---DD------DndlfheAYLLRIVTHMSIFIELLNp- 425 Tetrapisispora ...
XP_011275819 336 HPLRVLIASVISNKISPIIHSSLSLVG------S---V---MlgiEE------SneifsePYALRVVTHLAIFISLL--- 394 Wickerhamomyces...
XP_004179287 385 HPIRILMASVILDTTPSVVHSSIIMLA------NiinG---I---DN------DnelinePYLLRILAHLTIILDCIKp- 445 Tetrapisispora ...
XP_002554606 338 HPIRVLMGAVILDKIPTVVKSSTAMLL------D---V---VkgkDA------SndmveePYLLRVVTHLVILMDFI--- 396 Lachancea therm...
XP_002493312 380 HSIRVLSGSLITNSIGELLKNSSDLLNemitggD---E---S---KT------EadlikeSYLLRILVHLAIFMRMLDDs 444 Komagataella pa...

Q5RGI2       558 L--KEEVCVD--VLKAYISLLVKEKQVELIAFYVSHLP-ADLAVSQYAQFLEE-VTETEQRKHCLELATQAGLEVAAITK 631 zebrafish
Q6FR90       400 DrhALNETDTskLITSYITILKFYELFDCIPAYMTLLS-AEETIEAYSFVLST-IEESSEKRKQIELMSVLHLPCSEIIK 477 Candida glabrata
XP_003675058 398 TpgAVPKGDKykLVTAYISILKMHGYYDCIPIYISFLE-DDEILNAYSFVLST-MNEPELRQNQLELMKFLRLPVTNILK 475 Naumovozyma cas...
XP_001645697 406 --gTISESDKtkLITAYISILKSQELYDLIPIYISFLS-HNEAIEASSFILSN-LEGKDIRKKQLEICNFLKLPVEDMLK 481 Vanderwaltozyma...
XP_003668611 436 TpgIISKLDKkrLITAYISILKLHGLYESIPIYINFLE-PEDALEAYSFILST-MEDPIVREKQLKLMIFLKLPKSDILK 513 Naumovozyma dai...
XP_003684943 426 --eVVSKEDNynLITAYITVLRLHSLLEYIPVYVKFID-SDKGIDAYSFILST-LKDPDTRLKQIEISNSLYLPIVNILK 501 Tetrapisispora ...
XP_011275819 395 HpdAVSNEDKfkLLTTYILILRLYEQYELIPIYISFLT-ETEARDVYSLFLID-LFDPEERSNQLKLSRQYNLPLENILK 472 Wickerhamomyces...
XP_004179287 446 --nSIPNQDKskLITTYVSLLRMHKLYDTLPIYVSFLD-DEVILESYSILLST-IEDPLIRTEQIKLSNFLKLPTANILR 521 Tetrapisispora ...
XP_002554606 397 CpgLINEQDKskLITAYVTILSLYQLYNEIPVYISFLD-DSEALEAYSFFLSN-LTNAAARKKQLDLCNILKIPTANILR 474 Lachancea therm...
XP_002493312 445 ---IISGSNLnnLIKVYIARLSLYKQYDSIPVYISFIStHADTIETYTFILSSmITDKADRLKQLKEMRELELPLETIVK 521 Komagataella pa...

Q5RGI2       632 TVV-ETIRERDTdefshhdltpaldT-ATTVEDQQKIDVIDWLVFDPAQRAEALKQSNAIMRKFLASKKHDAAKMVFAKV 709 zebrafish
Q6FR90       478 KITqRVFDDTEQqyqpt---qvmsvCfETTKIDLHLINSVEWL-LEGKLYVDAMNSILALARRFLLNGKVKSLELFFERN 553 Candida glabrata
XP_003675058 476 KTTsRVFTETEPeytpd---eeisvSfGITDTDKHLILAVEWL-LQGKLFTDALESVLALSRRFLINGKVKALDYFFRRN 551 Naumovozyma cas...
XP_001645697 482 RTTqCVFAETESeytpvgditisfeS---SDIDRHLILGVDWL-IEGNLYEDAVESSIALSRRFLLNGKVKSLEMFLDEK 557 Vanderwaltozyma...
XP_003668611 514 RTTqRVFTETESeyepkn---eisvifEVNDIDKHLIYNVEWL-LEGKYYMDAMEAVIALARRFLINGKVKALDFFFKRN 589 Naumovozyma dai...
XP_003684943 502 RTTeRVFSETEQsyipn---tevliTkGVSDIDEHLILAVEWLIL-GKQYEDSIASVLALARRFLINGKVGALSLLFSRN 577 Tetrapisispora ...
XP_011275819 473 RTVeRVFSTTEEhyqins----gvtlqETDEIDNKLIRGVEWF-IEAKMYSDAIHASISLFRRFLLTGRTKAAEEFASRN 547 Wickerhamomyces...
XP_004179287 522 RTAeRIFLETQInyvpne---sininfNVDEIDKHLIFGISWL-IDGELYGDSIDSIIALSRRFLLNGKTKSLEYCYNNI 597 Tetrapisispora ...
XP_002554606 475 RTTqRVFDDTEGsynpt---agiivDnTVDEIDKRVVASVEWLT-EGKLYVDAINAIIVLSRRFLINGKIRSLSYLYETH 550 Lachancea therm...
XP_002493312 522 RTVqRVFEATEYlysnh---teiiiSaDVSHIDYKLMHTFDWFV-DADMSYEALDAIIVLMRRFLLNGKVAALVELHEHI 597 Komagataella pa...

Q5RGI2       710 -PEDSMREIY-------R----QWeeqgmDTPLPA-----------------EEENAIREHLCIRAYLEAHEAFNEWF-K 759 zebrafish
Q6FR90       554 dLTTVINQIE-------Iaia---------vgkQP-----------------INSSTRKELSQYENLIQGFVEYENWQkS 600 Candida glabrata
XP_003675058 552 sMDDLLKAYK-------L----EIis--qRD-SDE-----------------GPELKIEELLQYENLIHGLNRYEEWNkT 600 Naumovozyma cas...
XP_001645697 558 pIDDLLKNYQ-------L----SKih--eMDVDST-----------------E-DTSVLEIQQYRYLINIFKQYMEWEkT 606 Vanderwaltozyma...
XP_003668611 590 sVDDLVKNYD-------LtklaAQrm--sTDDDSI-----------------ILDCKTQELRQYERLIDGLNNYEQWNkT 643 Naumovozyma dai...
XP_003684943 578 eLSSLIKNYQ-------L----TKle---nSSYDS-----------------NSDFSIKELKEYHYLTDIFKQYEEWHkS 626 Tetrapisispora ...
XP_011275819 548 pLPQLLKNYD-------V----EQyg--vLADET------------------VSDNERNELLQYDALIRGLSSINAFAnR 596 Wickerhamomyces...
XP_004179287 598 dLPNIIKNYE-------L----EKim--tNNNTNAlhnsindnkgkyhddsnETDLKIKEIMQYQSLTEAFKRYEEWKkT 664 Tetrapisispora ...
XP_002554606 551 dIDNVIKNFE-------M----DTi------sDPN-----------------SCKAAVDEIKQYKELIDIHEQFEQWDaL 596 Lachancea therm...
XP_002493312 598 aIQKILDDYKlrdevwkN----HGsd--lALNLTT-----------------IPEYKLMEVSQYLKLVQISKQLHEYEyQ 654 Komagataella pa...

Q5RGI2       760 HMNcPPVkptapaqakftekvahemkeaEYkIE-LENWQGRLGALTEDVKERIYNVLLfvdgGWMVDVREdaee-----d 833 zebrafish
Q6FR90       601 VNQlNS-------------------------ESnIPSLIEKFQGFSNDINILIK--------DFLVELCEdeks------ 641 Candida glabrata
XP_003675058 601 IKLlNS-------------------------ESnIPSLIEKFQAYTRSTHDLIEN--------FLVNLSRdeg------y 641 Naumovozyma cas...
XP_001645697 607 VKLlNS-------------------------ESnIPSIIEKFQEFFQSTFKLIK--------TFLVDLTEnid------- 646 Vanderwaltozyma...
XP_003668611 644 VKLlNS-------------------------ESnIPSLIEKFREYTDGTYDIIK--------TFLVDLTEnhd------- 683 Naumovozyma dai...
XP_003684943 627 IKLlNTQ-------------------------SnIPSLIEKFTEYSKNTTDLIKF--------FLVELTAntd------- 666 Tetrapisispora ...
XP_011275819 597 PKVnGPI---------------------AN--------IEYINTIVQQLHSLIESLFL-----------Elsy------t 630 Wickerhamomyces...
XP_004179287 665 VQSlNPQ-------------------------SnIPTSIQKLQEYSEKTTNLVKI--------FLVELTDelnvknkris 711 Tetrapisispora ...
XP_002554606 597 LVNsQS-------------------------ESnLPHLLKKFKQLCSNVYRFSK--------SFLIELSEspg------- 636 Lachancea therm...
XP_002493312 655 GTLeEPS---------------------RS--------VNLINSLTNNLKQIILSFLE----GLYNPPAEsev------s 695 Komagataella pa...

Q5RGI2       834 seRSHQMTLLRRLCLPMMSFLLLTVLQRT-------ERH-QESLRLADIIASDQHkLYEVFSKD-ELQKFLQKMRESS 902 zebrafish
Q6FR90       642 -entaILYEIRALYIPYLIIELHKKLVEAsellkipKFI-SRALELTNFVANESErIYVLFQESgKLKEYLDLVAKTA 717 Candida glabrata
XP_003675058 642 tgR-DIIYEIRALYTPYLIIELHKGLVEAakllkipKFI-SEALNYTDLVANETDkIYLLFQTSgKLKEYLQLVAHTA 717 Naumovozyma caste...
XP_001645697 647 hkDHDILFEIRALYTPYLIMELHKGLVEAasllripRFI-KDALNITNLVANEDDkIYLLFQSSgKLKEYLQLVAQTA 723 Vanderwaltozyma p...
XP_003668611 684 hpeQEILHEIRSLYTPFLIIELHKGLVEAskllkipKFI-NEALNYTSLVANETDkIYLLFKSSnKLKEYLQLVANTA 760 Naumovozyma daire...
XP_003684943 667 gvDYDILFEIRALYTPYLIIELHKGLLEAasmlkipKFL-DQALRFTDLVANEESkIYLLFQSSgRLKEYLKLVAYTA 743 Tetrapisispora ph...
XP_011275819 631 dyETQIIQELRSLYIPYLIIQLHNIYVDGrky--rnSYL-KDALDLVNVVASESSkFYTLFQNCgRLQEYLKLIadca 705 Wickerhamomyces c...
XP_004179287 712 kdDFSILYEIRALYIPYLIIELHKGLIEAsrl-lniSLLtKDALKYTTIVANETDkIYLLFQSCgKLKEYLQLIAHTA 788 Tetrapisispora bl...
XP_002554606 637 iaGSDVIYEIRALYTPHLIVKLHNSLVTAsrelkieSFI-NEALSLANLVANETDrIYLLFQSSgRLQEYLQLIAKTA 713 Lachancea thermot...
XP_002493312 696 peDKLMYQELRELYIPIWIDTLFDILVENrki--stVYV-KEAADVVNLIADETNkFYYMLLKVgKLEPFLQKFAlit 770 Komagataella past...
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