Conserved Protein Domain Family
Upf2
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pfam04050: Upf2 (this model, PSSM-Id:281974 is obsolete and has been replaced by 461146)
Up-frameshift suppressor 2
Transcripts harbouring premature signals for translation termination are recognized and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay.
Links
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Statistics
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PSSM-Id: 281974
Aligned: 123 rows
Threshold Bit Score: 62.281
Created: 24-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7S858        923 DDE-----DGMvPDEDEDD--------------E---SDDDDGGEA-EDNEQQdntsrynseseeeeivvtrqqeevdpE 979  Neurospora cr...
XP_001770263  930 adgqeeeeeleedkypDHDde-----------vE---EMEGGADTAgSEEEekvkvmqk-------------kmpetdpA 982  Physcomitrell...
XP_004976273  956 DGE-----SFPyEETLDDRle-----------nE---DHSEDIDAPvGSDEEGtvevrrk-------------vvqvdaK 1003 foxtail millet
CEL70623     1244 EEE-----DEEaLFGSADEseeeeedektgdekEa-gVAEDEDLRDyVREHVQ--------------------------K 1291 Neospora cani...
KFG47811        8 EEE-----DEEaLFGSVDEseeeeeenggeeeeEggaEDEAEDLRDyVREHVQ--------------------------K 56   Toxoplasma go...
EJK55310      197 DDDdsmehEPQdDAMDADDde-----------eEsddDDDDDDDSDySDGDDEmdd--------------------vdeA 245  Thalassiosira...
XP_002290022  907 ESTvasemETEvAPEECDSes---------------dTDESEVDEEeSDNEEEdgi---------------------deA 950  Thalassiosira...
XP_002185058 1217 DDE-----TESgDSDEDYEgv-----------tE---DDIDSESGGnSEEEEE--------------------------E 1251 Phaeodactylum...
CBN74240     1422 DDD-----DDEdEEEGGSGse-----------aE---EDGNDVDSQrQRDDVDegddgedeqevv---lngwgvgvertE 1479 Ectocarpus si...
XP_002981454  921 EEE-----DDVeRDEEGEEe----------------eEEAELEHAAvSEEDDHvklrck--------------skevdpL 965  Selaginella m...

Q7S858        980 EEA----------EFEREFAKMMAESLDSRKFERK----------------QQFDLPLPIKLKp-RE--STAVGE----- 1025 Neurospora cr...
XP_001770263  983 EEA----------EFDREYRALMQESIDSRKLEMRs--------------rPTLNMTIPLNLFdsKDhgRSGGTD----- 1033 Physcomitrell...
XP_004976273 1004 EQE----------DFDRELKAILQESLESRKLELa---------------rPTVNMTIPMNAFegSK--DLMAIEaadke 1056 foxtail millet
CEL70623     1292 EEAsrpqriytelQFDADFAQMMLASLNDAKTLRRp---------------TGSEMKIPPNVLk-------EAAE----- 1344 Neospora cani...
KFG47811       57 EEEl---------RFDADFAQMMLASLNEAKTLRRp---------------TSSEMKIPANVLkeTE--SLSEAP----- 105  Toxoplasma go...
EJK55310      246 EAEaaytrqledeAFEAELRRLTMDAIEKGKVTSKsg-------------gAKVSSQMPVAPQfaAK--KAGPAD----- 305  Thalassiosira...
XP_002290022  951 AAEaayirqlqdeAFESELRKLTMDALERGKMSARtg------------agGKVSSQMPAAPQfaKK--PGVAEP----- 1011 Thalassiosira...
XP_002185058 1252 FDEeaymrqleeeAFERELRRVTIEALEKGKNTSRklvaenmvsgsqtfkkKPTDLSKPVGASsaVA--PTFGLA----- 1324 Phaeodactylum...
CBN74240     1480 EDGea------edEFEALLSKTMSESVEKTKIARAtt-------------qVMGHMAVPRVLKntNV--RTATHQ----- 1533 Ectocarpus si...
XP_002981454  966 EDA----------DFEKELRALMQESVDSRKSELRa--------------rPTLNMMMPMNLLegTK--DHGRAQ----- 1014 Selaginella m...

Q7S858       1026 ----SSAANEAGpseap------------------------psgeK----MAFSLLTK-KGNRQQTRTVELPSDSHFAIA 1072 Neurospora cr...
XP_001770263 1034 ----IESGDEVVdd------------------------------qTsgtsVQFRVLVK-KGNKQQTKQLRIPRECSLVQS 1078 Physcomitrell...
XP_004976273 1057 nvcgDGEIGKPGdl------------------------------gD----VRVKVLVK-RGHKQQTKQMLIPGDCPLVQS 1101 foxtail millet
CEL70623     1345 ----SPSEGASGkrpqgeesptasdrlaadegeldfegplarpttV----MRLVLRRPdKRNRFVVRPLAVPTDAVLAES 1416 Neospora cani...
KFG47811      106 ----RPSSEEASarevltsgdadeg-------dldpdgplprpttA----MRLVLRRPdKRNRFVVRPLAVPTDASLAEH 170  Toxoplasma go...
EJK55310      306 ----DAESPFGAd--------------------------------G----MSFKLFKRgNKGRQEEVQFVVPRDNSLAQR 345  Thalassiosira...
XP_002290022 1012 ----KQESEVDPttnpf------------------------ggseG----MSFKLLKKgNKGKMEEKQFLVPTSTNLARR 1059 Thalassiosira...
XP_002185058 1325 ----GTP--------------------------------------G----ITFQLLKKgNKGKVEAKEIVVPSDTNFAKV 1358 Phaeodactylum...
CBN74240     1534 ----APLTGGS----------------------------------G----VAFKLLKRgNKGKMEAQEVVVPESTSLAAQ 1571 Ectocarpus si...
XP_002981454 1015 -------DPESGdegide----------------------hgsghN----VAFRVLVK-KGNKHQLKQLKIPRDSSLVQS 1060 Selaginella m...

Q7S858       1073 MK---KKQQAEKEEQQRIKNLVLN 1093 Neurospora crassa
XP_001770263 1079 TK---QKEAAELEEKQDIKRLVLE 1099 Physcomitrella patens
XP_004976273 1102 TK---QQSAAELEEMQNIKRKILE 1122 foxtail millet
CEL70623     1417 SRrkdQQAQQEEAERANLKRFVMD 1440 Neospora caninum Liverpool
KFG47811      171 SRrkdQQARQEKAERADLKKFVIe 194  Toxoplasma gondii p89
EJK55310      346 AT---RQDDEAAKERELLKARALq 366  Thalassiosira oceanica
XP_002290022 1060 AT---KVDDEAVKEKEMIKARVLq 1080 Thalassiosira pseudonana CCMP1335
XP_002185058 1359 AS---KQDDAAARERNFIKQRVLq 1379 Phaeodactylum tricornutum CCAP 1055/1
CBN74240     1572 VN---RNEEASREESFIIKARVLa 1592 Ectocarpus siliculosus
XP_002981454 1061 TR---QKEAAELEEKQDIKRLVLE 1081 Selaginella moellendorffii
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