Conserved Protein Domain Family
Solute_trans_a
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pfam03619: Solute_trans_a (this model, PSSM-Id:281602 is obsolete and has been replaced by 460991)
Organic solute transporter Ostalpha
This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters. In plants they may transport brassinosteroid-like compounds and act as regulators of cell death.
Links
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Statistics
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PSSM-Id: 281602
Aligned: 303 rows
Threshold Bit Score: 68.2686
Created: 25-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5CLF6         4 KWVVSSVATLLTLIISVVNIMHQYLNLCKPKLQLCICRILTMIPVYAIISYISYLFVDyaAPL--NIVRDCYEGYVMFSF 81  Cryptosporidium...
NP_001004546  34 lytVLTLMATASMLVFIEECIYIYKKVPAH-KKSTIIWVTGVAPVMAIMSCLGMWVPR--ATMftDMTSATYFAIVVFKF 110 zebrafish
XP_003967925  34 lySMLTFMALMSMLVYLEECVYIYKKVPAK-KKSVIIWVNGAAPVIGTMSCLAMWIPR--ATMftDMTSACYFAVVVFKF 110 torafugu
XP_004081287  34 lYAILTFMTAVSMLVFIEECIYIYKKVPPN-KKSVIIWVTGAAPIICTMSCLGMWIPR--STMytDMTSACYFAIVVFKF 110 Japanese medaka
XP_007252358  33 LYSVLTFMAAVSMLIYIEECIYIYRKIPSH-KKSIIIWVNGAAPVIGTMSCLGMWIPR--ATMftDMTSATYFAIVVFKF 109 Mexican tetra
XP_006627941   1 -------MALLSVLIYMEEAVYIYKKVPSP-KKSAIMWVNGAAPVIGVTSCVGMWIPR--SSMftDFTAASYFAIVIYMF 70  spotted gar
XP_004003052  53 lmviMTLLVLASIAIFLETAVYLHKNTRCPIKRKTLIWCSSSPTIVSAFSCFGLWIPR--ALTlvEMAITTFYAMCFYLV 130 sheep
XP_001373826  53 itgilTLFTVSSVIIYVEDAIYLYKNTRCPIKKKTLIWSSSAPTVVSIFCCCGLWIPR--SLMfvEMAVTSYFAICFYLI 130 gray short-tail...
XP_005051181 130 ilGLCTIMTLLSVVIYAEEVSYLFRKIRCPIKMKTLCWSSSAPTVVSVVSCFGLWFPR--SMMvvEMATTAYFAVCFYLL 207 collared flycat...
NP_001264626  52 iTGLATILTLVSVVIYVEEALYIYRKTSCPIKMKTLCWSSSAPTVVAVFSCFGLWIPR--SMMvvEMATTMYFAICFYVM 129 chicken

Q5CLF6        82 LQLLIFYMGGDQVILSVLesnkikaeiwphhhfnhslsmvglastagsiesneeeisvnimdicpdyfcekdnldevsid 161 Cryptosporidium...
NP_001004546 111 LILMIEEVGGDNAFLRRCekqtfkistgpcc------------------------------------------------- 141 zebrafish
XP_003967925 111 LILMLEEVGGDEAFLRRAgqhklkistgpcc------------------------------------------------- 141 torafugu
XP_004081287 111 LIMMLEEIGGDQAFLRRMgkhtlristgpcc------------------------------------------------- 141 Japanese medaka
XP_007252358 110 LILMIEECGGDEAFLKRSanktfristgpcc------------------------------------------------- 140 Mexican tetra
XP_006627941  71 LVMMIEECGGDEAFLKRCgrdrlristgpcc------------------------------------------------- 101 spotted gar
XP_004003052 131 MQAMVEGFGGKEAVLRTLkdtpvmihtgpcc------------------------------------------------- 161 sheep
XP_001373826 131 MLVMVEGFGGKEAVLRTLkdskmivhtgpcc------------------------------------------------- 161 gray short-tail...
XP_005051181 208 MMVMIEGFGGKEALLSTLkdvpmvvstgpcc------------------------------------------------- 238 collared flycat...
NP_001264626 130 MMVMVEGFGGKEALLSTLkdvpmvvstgpcc------------------------------------------------- 160 chicken

Q5CLF6       162 sglrgdepanhhlkiARFYSFIKLGVLQFVTLKPISALISLFL-----ESIGLYG-SgsfsfkrgyLYITALNsiSVSLS 235 Cryptosporidium...
NP_001004546 142 ---cccpclpnvpitRRSLFILKLGSYQFALMKLVLTIFSIVLwtngsFSLTNVSaSga------aIWINSFIgvLTIIA 212 zebrafish
XP_003967925 142 ---ccclclpyvaitRRSLFLLKLGSFQFAVLKIVFTILSIVLytnglFDLSDLSiSgs------aIWINPFVgiLTIIA 212 torafugu
XP_004081287 142 ---cccpclphvaitPRTLFLLKLGSFQFALLKVVFTILSIVLhtngnFVLTDLSiTga------vMWINPFVgiLTVIA 212 Japanese medaka
XP_007252358 141 ---cccpclpnvqvnRRSLFMLKLGAFQFAILKVVFTILSIILwtnenYDVADLQiTga------aIWINPGVgiLTIIA 211 Mexican tetra
XP_006627941 102 ---cccpclpyagisRRTLFLLKAGSFQFALLKTVFTILSIVLwangnFDLADLSiTga------aIWINPFVgiLTIIA 172 spotted gar
XP_004003052 162 ---cccpccprikitRKRLQLLLLGPIQYAFFKISLSLVGLFLipdgiFDPSDISeRst------aLWINTFLgvSTLLA 232 sheep
XP_001373826 162 ---cccpccprliltKRKLQLLMLGPFQYAFFKMVFVLLGLLLvpdgiYRPEDISaGst------aLWMNTILgvSTLLA 232 gray short-tail...
XP_005051181 239 ---cccpclpritmsRKKLKLMILGTFQYAFFRAVAVFLGLILsadgnYNPADISeEsv------aLWINTLVgvSTLFG 309 collared flycat...
NP_001264626 161 ---cccpclpritisRRKLQLLMLGTFQYAFLRTAGVFLGLVLytdgnYNPADISaEsv------aLWINTVIgvSTLFG 231 chicken

Q5CLF6       236 VYSLFLLYISISEqLapIRPVLKFFCIKLIIFMSFWQSIILSVLSH--F------GiypdepnytiklhNWLLtIEMTVC 307 Cryptosporidium...
NP_001004546 213 LWPVAIMFMHVREaLrtLKIVPKYAMYQLVLILSQLQTAIINILALngTiacsppYssqarg--ymmsqQLLI-VEMFII 289 zebrafish
XP_003967925 213 LWPVAIMFMHLRTtLrtLKIIPKYAMYQLVLILSQLQTAIINILALngTiacappFsskarg--ymlsqQLLI-LEMFII 289 torafugu
XP_004081287 213 LWPVAIIFMHLRTtLqtVKIIPKYAMYQLVLILTQLQSAIINILAIngViacsppFssvarg--ymlsqQLLI-LEMFII 289 Japanese medaka
XP_007252358 212 LWPVAIMFMHVRNtLrsLKIIPKYAMYQLVLILSQLQSAIINILAMngTiacsppYssqarg--ylmsqQLLI-LEMFII 288 Mexican tetra
XP_006627941 173 LWPVSIIFKHVQGlLrsLKIIPKFAMYQMVLILSQLQSAIINILAMggTiacappFssqarg--tfmnqQLLI-MEMFII 249 spotted gar
XP_004003052 233 LWTIGIIFRQARLhLgeQNIGAKFVLFQVLLILSALQPSIFSVLANggQiacsppFsskirs--qvmncHLLI-LESFLI 309 sheep
XP_001373826 233 LWALGILFRQARLhLrsQNMGGKFALFQVLLVLTALQPSIFSILASvgQiacsppYsskirs--qvmncHLLV-AETCLL 309 gray short-tail...
XP_005051181 310 LWALGILFRQARLhLaeQNMQGKFTCFQILLLLTALQPAIFSILANsgSiacsppFsskars--qqmnvQLLI-PQTFIL 386 collared flycat...
NP_001264626 232 LWALGILFRQARLhLkeQNMQAKFTCFQILLLLTALQPAIFSILANngNiacsppFsskars--qqmnmQLLI-PQTFML 308 chicken

Q5CLF6       308 AIIYGIAFTIK 318 Cryptosporidium hominis
NP_001004546 290 TLVTRVLYRrq 300 zebrafish
XP_003967925 290 TLVTRLLYRrq 300 torafugu
XP_004081287 290 TLVTRMLYRrq 300 Japanese medaka
XP_007252358 289 TLVTRLLYRre 299 Mexican tetra
XP_006627941 250 TLVTRMLYRra 260 spotted gar
XP_004003052 310 TVLTRIYYRRK 320 sheep
XP_001373826 310 TILTRIYYRKr 320 gray short-tailed opossum
XP_005051181 387 AVLTRMYYRkq 397 collared flycatcher
NP_001264626 309 AVVARMYYrkq 319 chicken
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