1OIS,1R49,2B9S


Conserved Protein Domain Family
Topoisom_I_N
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pfam02919: Topoisom_I_N (this model, PSSM-Id:280987 is obsolete and has been replaced by 460746)
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Eukaryotic DNA topoisomerase I, DNA binding fragment
Topoisomerase I promotes the relaxation of DNA superhelical tension by introducing a transient single-stranded break in duplex DNA and are vital for the processes of replication, transcription, and recombination. This family may be more than one structural domain.
Links
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Statistics
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PSSM-Id: 280987
Aligned: 142 rows
Threshold Bit Score: 267.01
Created: 14-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1OIS_A          4 KWVTLKHNGVIFPPPYQplPSHIKLYYDGKPVDLPPQAEEVAGFFAALLESDHAKNPVFQKNFFNDFLQVL-----KE-- 76   baker's yeast
P41511        162 KWDVLIHKGPRFPDPYQplPKDVKLKYDGRPVDLPWQTEEIAMFYAVKLETQHAQNAIFNRNFFDDFKTDLkkyppRD-- 239  Ustilago mayd...
XP_001731429  121 RWTTLIHKGPKFPEPYTplPKDVMLKYDGHPVPLPPESEEVAMFYAVKLESQHASNPIFNRNFFEDFCGYL-----KQ-- 193  Malassezia gl...
XP_002051562   67 KWQTLEHNGPLFPGAYErlPENVHFLYDNCPIELTEQAEEVATFYAKVLGTPFVELSEFNENFFKDFRSCLs---vEQ-- 141  Drosophila vi...
XP_002003060   64 KWQTLRHNGPCFPADHErlPADVKFYYDNCPVELTEQAEEVATFYAKLMKTAFVQMREFNQNFFNEFRSCLs---eEQ-- 138  Drosophila mo...
XP_001965162   18 KWTTLSHNGPLFVDHYQalPKEVAFYYEDLPLKLNPTAEELATLYAKFMNSPLAITDTFNENFFKDFQSHL-----SRal 92   Drosophila an...
WP_020863907    3 KWRTLVHNGVALPPPYQ--PKGLSIKIRGETVKLDPLQEEMAYAWALKKDTPYVQDPVFQKNFLTDFLKTF-----NG-- 73   Candidatus Ca...
WP_012215705    2 KWKTLQHKGILFPPAYEa--QGIKIKIKGEKVDLNLDQEEMIYQWAKKKDTPYAQDKVFQKNFTADFAKTL-----DS-- 72   Nitrosopumilu...
ADK25971       11 KWQTLEHKGVAFPPEYQ--PRGIVVTIRGEKLALNRDQEELIYAWAKKKDTHYVQDPVFQENFMSDLRPLL-----PE-- 81   Candidatus Ni...
WP_013481455    2 NWKTLQHSGIHFPPEHEv--KGFKIKVKGKQVNLTPLQEEMAYQWAKKKDTPYAQDKVFQKNFARDFAKEL-----GI-- 72   Cenarchaeum s...

1OIS_A         77 SGGplngieIKEFSRCDFTKMFDYF-------QLQK----E-QKKQLTSQEKKQI----RLEREKFEEDYKFCELDGRRE 140  baker's yeast
P41511        240 GTQ------IKSFDKLDFRDMYNYW-------RSLKdaelE-RKKALAPSARKRE----IEERKAEETKWKICLVDGVEQ 301  Ustilago mayd...
XP_001731429  194 YPPkdg-tkIQKFEKLDFRDMYNYW-------MSLKvaeaE-RKKSMAPSMRKAE----LAARRAIDNEYKLCLVDGIEQ 260  Malassezia gl...
XP_002051562  142 RLH------FTSFDLCNFQKIHQYL-------EEQQ----E-AR---------------SQQELEEDERYGYCYIDGERH 188  Drosophila vi...
XP_002003060  139 RRY------ITCFELCNFCDISQYL-------ECQR----E--------DEKERI----AEEN----KLYGYCLVDGESR 185  Drosophila mo...
XP_001965162   93 RRQ------ILSFELCDFTKIAFYI-------QGQQ----GvQRKLMTP---------------MMRNHYGYCTIDGKRH 140  Drosophila an...
WP_020863907   74 RFQ------DVTINEIDFSEVYEYV-------ERER----Q-LK--ADKEYRKKIsaerKRLREELKARYGWAEMDGKRF 133  Candidatus Ca...
WP_012215705   73 KFK------KISYEDIDFSDAYKLV-------DKEK----D-LKEMMTKEEKKAIaakrKELREELKSKYGVAVMDGKEV 134  Nitrosopumilu...
ADK25971       82 KFR------NITIKDIDFSAAYRLAdeekrmkEQEK----E-RYKTLAKEEKKKIslakKAERERLKATYGKAVVDGVEV 150  Candidatus Ni...
WP_013481455   73 KLL------YKDL---DFSEAYRLV-------DMEK----D-KKDMMTKEEKKEIaakrKEIREGLKAKYGIAVMDGKEV 131  Cenarchaeum s...

1OIS_A        141 QVGNFKVEPPDLFRGR-GAHPKTGKLKRRVNPEDIVLNLSKDAPVPPAPEGH-KWGEIRHDNTVQWLAMWRENIFNSFKY 218  baker's yeast
P41511        302 RVGNVNVEPPGLFLGR-GAHPKAGKVKRRISPGDITINHSADHPAPQPPAGMgDWAEVVEKKDVTWLAYWKENINGQYKY 380  Ustilago mayd...
XP_001731429  261 KAGNVTVEPPGLFLGR-GAHPKAGRVKTRIQPEQITINHSADHPPPKPPKGH-SWGEVVERKDVTWLALWRENINGGFKY 338  Malassezia gl...
XP_002051562  189 RINQFRIKPPGLCCPRkGYSLTMGMIRPRVLPEDIMINCDEYAEPPAPPPGH-RWRQVVHDRSVSWLYSWHDLVSGNTYY 267  Drosophila vi...
XP_002003060  186 RITQFRISRPGLCCPRhGFSTTMGTIRPRVLPEDVVINCDENEEPPAPPCGH-LWAAVVHDRTVRWVYAWNDIVTGcmhh 264  Drosophila mo...
XP_001965162  141 RVPHFSFDGPSLYRRS-G--PKYGMVKPRIQPEDVNIN-SQENGAPGAPDGH-TWKSVIHDRRVDWLWSWTDALSGRVHY 215  Drosophila an...
WP_020863907  134 EIANWMVEPPGIFMGR-GNHPLRGRWKPRVYEEDITLNLGEDAPVPP----G-NWGQIVHDHDSMWLARWDDKLTGKEKY 207  Candidatus Ca...
WP_012215705  135 EVGNYMAEPPGIFIGR-GEHPLRGRWKPRVTAKDVTLNLGKEAKVPE----G-KWGKIIHDKDSMWLASWMDFLTQKRKY 208  Nitrosopumilu...
ADK25971      151 DIANWLVEPPGLFMGR-GQHPMRGRWKPRVRPQDVTLNLGENAPVPE----G-NWKEIVHDHSSTWLATWIENLTGKRKY 224  Candidatus Ni...
WP_013481455  132 EIASYMAEPPGIFIGR-GKHPLRGKWKRRIGPQDVVLNMGTKAKAPP----G-KWKKIVHEKDGIWIAKWTDNLVKKDKY 205  Cenarchaeum s...

1OIS_A        219 VRL 221  baker's yeast
P41511        381 VFL 383  Ustilago maydis 521
XP_001731429  339 VFL 341  Malassezia globosa CBS 7966
XP_002051562  268 VRa 270  Drosophila virilis
XP_002003060  265 ayp 267  Drosophila mojavensis
XP_001965162  216 qvi 218  Drosophila ananassae
WP_020863907  208 VWL 210  Candidatus Caldiarchaeum subterraneum
WP_012215705  209 VWL 211  Nitrosopumilus maritimus
ADK25971      225 VWL 227  Candidatus Nitrososphaera gargensis
WP_013481455  206 VWL 208  Cenarchaeum symbiosum
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