3EQ5


Conserved Protein Domain Family
Ski_Sno
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pfam02437: Ski_Sno (this model, PSSM-Id:280577 is obsolete and has been replaced by 460558)
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SKI/SNO/DAC family
This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development.
Links
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Statistics
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PSSM-Id: 280577
Aligned: 37 rows
Threshold Bit Score: 135.008
Created: 21-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3EQ5_A        23 MPS-DSSTELTQTVLEGESISCFQVGGEK-RLCLPQVLNSVLREF--TLQQINTVCDELYIYCSRCTSDQLHILKVLGIL 98  human
XP_008433745  82 VENiPQNNECKMVELRGAKVASFTVDGCE-LICLPQAFDLFLKHLvgGLHTVYTKLKRLEITPVVCNVEQVRILRGLGAI 160 guppy
BAM73874      91 TSD-PSANECKLVDYRGQKVAAFIIQGDT-MLCLPQAFELFLKHLvgGLHTVYTKLKRLDIVPLVCNVEQVRILRGLGAI 168 domestic silkworm
XP_007123391  67 sgN-TNTNECRMVDMHGVKVASFLMDGQE-LICLPQVFDLFLKHLvgGLHTVYTKLKRLDISPVVCTVEQVRILRGLGAI 144 sperm whale
XP_002407755  96 ipsdaSATDCRLIDYRGAKVAAFYVAGEY-LLCLPQAFELFLKHLvgGLHTVYTKLKRLDITPIVCNVEQVRILRGLGAI 174 black-legged tick
CCD74622      39 pNL-PENNQVHFLEYRGAHLATFTVNGRD-LICLPQAFELFLKHLvgGLHTVYTKLKRLDIIPVVCNVEQVRILRGLGAI 116 Schistosoma man...
CDS34290      12 vT----NSQVHILEYRGAQLAAFNVEGRGlLICLPQAFELFLKHFvgGLHTVYTKLKRLDIQPVVCNVEQVRILRGLGAI 87  Hymenolepis mic...
EKC27827      58 aCN-PDNNVCKVITYRGEKVAAFTVNGIE-LICLPQAFELFLKHLvgGLHTVYTKLKRLDITPVVCNVEQVRILRGLGAI 135 Pacific oyster
XP_011666704  32 sND-PANNECKLIEYRGAKIASFNINGDC-MICLPQAFELFLKHLvgGLHTVYTKLKRLSITPVVCNVEQVRILRGLGAI 109 purple sea urchin
CBY33885      39 eST-PQNNECRLVEVHGHKIAAFTIHNEE-YICLPQAFEIFLKHLvgGLHTVYTKLKRLSITPLVCNVEQVRTLRGLGSI 116 Oikopleura dioica

3EQ5_A        99 PFNAPSCGLITLTDAQRLCNALLR 122 human
XP_008433745 161 QPGVNRCKLISRKDFETLYNDCTN 184 guppy
BAM73874     169 QPGVNRCKLLSCKDFDVLYKDCTT 192 domestic silkworm
XP_007123391 145 QPGVNRCKLITRKDFETLFTDCTN 168 sperm whale
XP_002407755 175 QPGVNRCKLLSCKDFDALYKDCTT 198 black-legged tick
CCD74622     117 QPGVNRCKLIAPQEFDILYADCTN 140 Schistosoma mansoni
CDS34290      88 QPGVNRCKLIAPREFDILYADCTT 111 Hymenolepis microstoma
EKC27827     136 QPGVNRCKLISCKEFDVLYDDCTN 159 Pacific oyster
XP_011666704 110 QPGVNRCKLLTRKQFDILYEDCTT 133 purple sea urchin
CBY33885     117 QPGVNRCKLITRRDFESLYQDCTT 140 Oikopleura dioica
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