1W80


Conserved Protein Domain Family
Alpha_adaptin_C
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pfam02296: Alpha_adaptin_C (this model, PSSM-Id:280460 is obsolete and has been replaced by 426707)
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Alpha adaptin AP2, C-terminal domain
Alpha adaptin is a hetero tetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site.
Links
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Statistics
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PSSM-Id: 280460
Aligned: 21 rows
Threshold Bit Score: 125.133
Created: 12-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1W80_A       137 FFQPTEM-ASQDFFQRWKQLsnPQQEVQNIFK----------A----KHPMDTEITKAKI-IGFGSALlEEVDPNPANFV 200  house mouse
Q4PEU6       864 FVEPVQL-GANDFFERWRQIggAPREAQKIFSfk------lsA----AGQVDVARQRRIL-EGARMQVlEGVDANATNSV 931  Ustilago maydis
Q86KI1       872 FFEPLRL-SSGDFFARWKTIsgKPLEIQEIFK----------S----TKPIDIQSYNRVIqEGLNITVlKQVDPNPNNIV 936  Dictyostelium ...
Q00WR4       809 FLSPMTIaSPQEFIARWHQMvsAGQQ-QKIMDl--------aP----QYATGIESVVNAF-TGMHLAVhKGLDPNPANLV 874  Ostreococcus t...
Q1EQ22       852 FLVQEPL-EPNIFMQYWNTIgnAT-EKKSIIQm--------kQ----NNPIDLPTVL----GGMRFIC---LDVKPEQIV 910  Entamoeba hist...
Q4W9N5       811 YMEPSTL-SAEEFFKRWRQIggPPLEAQHTFGvt-------aK----AKNVSETFTRRLV-EGFHWRIlENVDPNPNNIV 877  Aspergillus fu...
Q0UJD2       843 YQEGAEL-SAEDFFKRWKQIggAPREAQRIFGlv-------nK----NRTMNSDFVKKVV-AGFKWGIvDGVDPNGKNIV 909  Phaeosphaeria ...
XP_956726    839 FMDQAEL-SADDFFKRWKQIggAPREAQRIFGl--------sGpkdgEREITESFIRQVL-EGFRWGLlYNVDPNSKNFV 908  Neurospora cra...
Q2GV39       822 FMDPAEL-SAEDFFKRWKQIggAPREAQHIFGlaatgggsraG----EREITEGFVRTVV-EGFRWGVlNGVDPNGKNLV 895  Chaetomium glo...
XP_001537444 812 YMDESTL-SPDDFFKRWRQIggPPLEAQSTFAvq-------gK----GRMITESFTRGIV-QGFRFRIlGGVDPNSKNVV 878  Ajellomyces ca...

1W80_A       201 GAGIIHTKTT-Q-IGCLLRLEPNl-QaqmYRLTLRTSKDTVSQRLCEL 245  house mouse
Q4PEU6       932 AAGVLHMADAgK-VGCLLRLEPNk-DaklARLTVRTTNDLASAEMLRI 977  Ustilago maydis
Q86KI1       937 ASCLFPFGSNgQpINSYIRIETNp-QanmCRLTIRSQSATLTNTIKNL 983  Dictyostelium discoideum
Q00WR4       875 SGSRFVGEKSgE-VLIGVRVESDanVrgrYRFTVASMDKDASRAVMET 921  Ostreococcus tauri
Q1EQ22       911 ACSSFPSFQN---IYVLLRIEINv-TsnkACIYVRAQDPSLAKVIHNL 954  Entamoeba histolytica
Q4W9N5       878 GCAVYQSH-GgK-TGCLLRLEPNy-ErkmFRVTIRATQEAVPQALAKq 922  Aspergillus fumigatus
Q0UJD2       910 GATVLHTSEGgK-FGCLMRLEPNf-DtqmYRITIRATDEAVPPVLIKA 955  Phaeosphaeria nodorum SN15
XP_956726    909 GASVVHTSEGgK-FGCLMRLEPNy-GtqmVRLTIRATDETVPPVLLKM 954  Neurospora crassa OR74A
Q2GV39       896 GASVVHTSEGgK-YGCLLRLEPNy-QtqmVRLTIRATEDALPPLLLKM 941  Chaetomium globosum CBS 148.51
XP_001537444 879 GCAVYQM-DGgK-TGCLLRLEPNy-EkkmYRITIRATQDAVPQALVKL 923  Ajellomyces capsulatus NAm1
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