Conserved Protein Domain Family
PIP5K
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pfam01504: PIP5K (this model, PSSM-Id:279801 is obsolete and has been replaced by 460234)
Phosphatidylinositol-4-phosphate 5-Kinase
This family contains a region from the common kinase core found in the type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K) family as described in. The family consists of various type I, II and III PIP5K enzymes. PIP5K catalyzes the formation of phosphoinositol-4,5-bisphosphate via the phosphorylation of phosphatidylinositol-4-phosphate a precursor in the phosphinositide signaling pathway.
Links
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Statistics
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PSSM-Id: 279801
Aligned: 369 rows
Threshold Bit Score: 90.9885
Created: 22-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A0DSC8       556 DLSCLQELTSTGKSGSFFYYTA----DGQFTLKTIHHQ-EFRFLKQ-IMRNYYYHLKNYP--ETLIIKLFGMHKIgiKYq 627 Paramecium tetr...
Q4Q241       115 ENRLKMEM-GEGRSQALFLKSK----TMLLMCKTISVE-EVHALLH-VLRAYTLHITAHP--SSLLMRFYMLLKV--SV- 182 Leishmania major
Q38BC4       122 nerqDLEL-SEGRSMALFLESK----SKYLLCKIIAKV-EVDVLLH-LLPRYAKHFREHS--NTLLMRFYMLLRV--EF- 189 Trypanosoma brucei
XP_001568671 115 EDCLRMEL-GEGRSQAFFLKSK----TMAFMCKTISVE-EVRVLLD-ILHAYMQHIAAHP--GSLLMRFYMLLKV--SV- 182 Leishmania braz...
XP_003852848  76 gnSKLQAMEDMGFSGSTFFTTE----DTAYIVKSVPRHfEHSFFKNdFLIPYVQHVHNNS--GSLLIRTTEFLAN----- 144 Zymoseptoria tr...
XP_002564283  75 aqppLKMIGDMGYSGSTFFSSL----DGHFVIKSLPRRfEHTFFQAdLLEPYYYYMRDHP--DSVLVWITDYVLS----- 143 Penicillium chr...
GAD96180      75 gsksLEPMGDLGYSGSTFFRTS----NSKFLIKSLPRHfEHSFFRNdLFLPYYEYMSSHP--ESLLVRITDFLMS----- 143 Byssochlamys sp...
XP_009223468  92 aracLKPVGDLGYSGSTFFTTS----NAKFMIKSLPRRfEHTFFTHeLLDPYISHMRHLP--HSLLVRITDMVFT----- 160 Gaeumannomyces ...
CCE28643      95 yvpslESAADLGYSDSSLLHTS----DGKYLVKSLNRSrESDSVVNeLFDSYTVHVKTHP--SSLLARVTDVLYA----- 163 Claviceps purpu...
CCA70892     110 taSSLKSLSNLGLSGSAFFHTEgpstNAGLIIKSINRAfEYEFMHEtLLPRYIEYIEARPgaDSLLTRITDVLFC----- 184 Piriformospora ...

A0DSC8       628 tmlrEKVI----------YFVIMSN-VFS-----TNQ---EIN---VRYDLKGSTYGRYTId---NDPTVA--------- 673 Paramecium tetr...
Q4Q241       183 ----RSEE----------GYILCFNdVFG-----TAS---VLH---EKWDIKG----RVPKngkhLHYPHLigsgyepdp 233 Leishmania major
Q38BC4       190 ----RGEL----------GYVLCFGdVFA-----PCR---TLN---EKWDLKG----RRPKpgkyKHFAKLfqhpydstt 240 Trypanosoma brucei
XP_001568671 183 ----RKEK----------GYILCFNdIFA-----AAS---VLH---EKWDIKG----RIPKpgksLRNPDFlrrgselnl 233 Leishmania braz...
XP_003852848 145 ----KHFTigqilqlaptHHIAMEN-LLYqqgk----------nhwETYDLKPMSYF----------------------- 186 Zymoseptoria tr...
XP_002564283 144 ----PYVTlgtlfgctpaHHIVMEN-ILLgk--dEDPngg----qwETYDLKPIDYF----------------------- 189 Penicillium chr...
GAD96180     144 ----PYPTlgsllgispsYHVIMEN-VLCgr--tEDPakd----qwETYDLKPTDYF----------------------- 189 Byssochlamys sp...
XP_009223468 161 ----PLPTlggilglaptHHIIMEN-LLYgq--gATSgag---eywESYDLKPNDYF----------------------- 207 Gaeumannomyces ...
CCE28643     164 ----PRATlgsilgiqsrHHIIMEN-LLQglgnnRDGpa--dDvkwETYDLKPDDSS----------------------- 213 Claviceps purpu...
CCA70892     185 ----ADLSlgealnvsprHYMVMVD-VL------GDLkavKGA---QKWDLKPSGFF----------------------- 227 Piriformospora ...

A0DSC8       674 -------------------------------------------RKDLNFLEDKEKnm---------------rLNINKNK 695 Paramecium tetr...
Q4Q241       234 hatkpppkrhvlanpaidasqqhpgresavvvrgtkdaqglptLHDKDLTRL---------------------FWVPRTA 292 Leishmania major
Q38BC4       241 gqsttpgtdttqyf------psgtgisglkempkatdknklatKKDKDLTRY---------------------FWLDKEQ 293 Trypanosoma brucei
XP_001568671 234 hlieaqkkrngivkpvtdaseqlynredgvvvkeakgaqspptLHDKDLTRL---------------------FLLPQNT 292 Leishmania braz...
XP_003852848 187 -------------------------------------------YPERDIAGGA-Ltseetksk--ladkfkdkLLLTLDQ 220 Zymoseptoria tr...
XP_002564283 190 -------------------------------------------YPERDLIPEP-Lvseetlnk--ladtfndkLHLWKKD 223 Penicillium chr...
GAD96180     190 -------------------------------------------YPERDLLPQ--Ltseetmsk--lvdtfedkIRITRAQ 222 Byssochlamys sp...
XP_009223468 208 -------------------------------------------FPERDLAGGR-Lapqsvkdk--lidefpdkIKVTEQQ 241 Gaeumannomyces ...
CCE28643     214 -------------------------------------------SSEHDLADGASLrsdeavrg--fvgeildqVDAPPLV 248 Claviceps purpu...
CCA70892     228 -------------------------------------------EPTRDLVPD-IIkseatksgladtldadvrIKLTKSQ 263 Piriformospora ...

A0DSC8       696 SMLFFNQLEKDCKFFEDNDIIDYSLLL----------------------------------------------------- 722 Paramecium tetr...
Q4Q241       293 RKRLVEELLRDYDFLKNAGMMDYSLLI----------------------------------------------------- 319 Leishmania major
Q38BC4       294 REKLLLTLRDDCKFLASVGLMDYSLLI----------------------------------------------------- 320 Trypanosoma brucei
XP_001568671 293 RKRLLEQLLRDYDFLNSAGMMDYSLLI----------------------------------------------------- 319 Leishmania braz...
XP_003852848 221 AEALKYQLEKDTSLLATCNAVDYSLFLvripiteapnpfddpq------------------------------------- 263 Zymoseptoria tr...
XP_002564283 224 YDAFMQSLEADTKFLGEANAVDYSLFLvrmpasskpa------------------------------------------- 260 Penicillium chr...
GAD96180     223 YEELKRTVSRDTAFLQSCNVVDYSLFLvrfpasseppv------------------------------------------ 260 Byssochlamys sp...
XP_009223468 242 RQQLLETLGNDTQLLADHNAIDYSLFLvrypgpnhpswqggddddtndaasds-----------------------glis 298 Gaeumannomyces ...
CCE28643     249 KQELIDILLEDTKFLARSNIANYSLLFarfpkaevrpaatiege------------------------------------ 292 Claviceps purpu...
CCA70892     264 YDDLIRVLEQDTAFLEELETVDYSLLLgrfpassspqpplgldasstvhlpisdvlqqgaskikralgisssqetedvap 343 Piriformospora ...

A0DSC8       723 ---------------------GLhakgnkqldnessvysenpqldnf--------------------------------- 748 Paramecium tetr...
Q4Q241       320 ---------------------GVayqddktrpsdkhcgiestnvtsssavapastsaearpaslaq-dshpsgtrtmltt 377 Leishmania major
Q38BC4       321 ---------------------GVayeekgisnptkrlrsmrmpyprcgppegamenrpe--------------wtmtcgg 365 Trypanosoma brucei
XP_001568671 320 ---------------------GVtyhenkapqsgrhcisdrmsnsaqhdaasasswaevrpaplakdshlsdkktshsvt 378 Leishmania braz...
XP_003852848 264 -----lnatpllppdppsfrtGMpstdgrwvyr----------------------------------------------- 291 Zymoseptoria tr...
XP_002564283 261 -----------ilgrhspwreGLpsadgkwkyr----------------------------------------------- 282 Penicillium chr...
GAD96180     261 -----------vggrrsqwrvGVpsadgkwkyr----------------------------------------------- 282 Byssochlamys sp...
XP_009223468 299 raggalggvpvvssdanswrtGIldvegrwtyr----------------------------------------------- 331 Gaeumannomyces ...
CCE28643     293 -----edqiastvqvspswrsGVsstdgkwiyr----------------------------------------------- 320 Claviceps purpu...
CCA70892     344 tagasasgregqkltgddftkGVlsadgewvyr----------------------------------------------- 376 Piriformospora ...

A0DSC8       749 -----skmvtvdnqytlhigiidiltnfsTKKKLEFLSKRV--------IYGPTISAIPPRDYAERFLKFLKDH 809 Paramecium tetraurelia
Q4Q241       378 vpefangvrsfdgqemyyigvidvlttytLKKKSANFFKSLlw-----kQKT--LSTIPPDRYAQRIASFTELI 444 Leishmania major
Q38BC4       366 eckfskgifslynqevyyigvidvltpytFKKKLAKLFKSFlw-----rMDT--LSTIPPLKYCERILQFTEDI 432 Trypanosoma brucei
XP_001568671 379 ppefangvrsvceqeiyyvgiidvltaytIKKKGANFFKSFlw-----eQNM--LSTIPPDYYARRLTSFTELI 445 Leishmania braziliens...
XP_003852848 292 --------------------aavldffwaKHKAHAKAMSLLinaynifdRKGPMSVTTNSPEYRQRFLNMIYDM 345 Zymoseptoria tritici ...
XP_002564283 283 --------------------avildffwaRHKFHAQALSGAvqtfnvvgRKGPMSITTTAGEYREKFLTMVREM 336 Penicillium chrysogen...
GAD96180     283 --------------------avlldffwaKHKLRAQAMTGMvqtfnvvgRKGPMTITTTAEEYQQKFMAMVDGl 336 Byssochlamys spectabi...
XP_009223468 332 --------------------vvvldffwaRHKFQARAMTSLvklfnklaHKGPMSITADPPEYRQRFLGMVEDI 385 Gaeumannomyces gramin...
CCE28643     321 --------------------aalldflwsTHKTCAKERTGFvgaisslfKKGRDSIPTEPEEYRSEFMDVVRRq 374 Claviceps purpurea 20.1
CCA70892     377 --------------------ltivdflwnVNKLVPTVMRTAg------kVLPDQTITTEPARYRQEFMKMVEEY 424 Piriformospora indica...
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