1AYX_A 27 EVSLYYLLQNIAYPEGQFNNGVPGTVIASPSTSNPdyy---------yqWTRDSAITFLTVL--------------SELE 83 Saccharomycopsis fi... Q9W391 8 GVRLDYYQRIVHRLILAHQEPVTGLFPASNVNSHA--------------WIRDNVYCILAVWglsmaykkiadqdeDRAK 73 fruit fly Q9VLS1 48 VKQLDIYYGIVKRQLLRYQSPITGLFPVMSTdqv-------------vgSVRDSVYCASAVWslyqay---rriddDRGK 111 fruit fly Q8YW30 8 QARLEYYYQQIKTVIMIRQNPITGLLPASTAITAHgdy--------tdaWVRDNVYSILAVWglalay---rkvdeDQGR 76 Nostoc sp. PCC 7120 Q97V93 207 KSFNDLYKASIYTMLGSIYAP-SGGVIAAPTTSLPeveggkrnwdyrfaWVRDSSIIAEALLeags-------iveARRI 278 Sulfolobus solfatar... Q10211 255 GRYREFVQRNALTLKLLIYEP-TGAVIASPTFSLPedlggvrnwdyrftWIRDSAFTIYALAqlgf-------raeAVEY 326 Schizosaccharomyces... Q9HLE2 203 GMYHSMVMRSALALKVLFYEP-TGMMVAAPTASLPeaiggernwdyrytWIRDTAYVIEALAtigy-------kreAVSF 274 Thermoplasma acidop... Q9KYJ7 222 GPYREAVVRSSIALKAMTYGP-SGGIVAAPTTSLPeeiggqrnwdyrysWLRDASTTLAALLgtgy-------lqeAQAW 293 Streptomyces coelic... Q9S223 231 GPYREAVVRSLITLKALTYAP-TGGIVAAPTTSLPediggvrnwdyrytWLRDAAITLSSLLrtgy-------reeARAW 302 Streptomyces coelic... Q9RJ38 216 GPHRDAVVRSLITLKALTYQP-TGGIVAAPTTSLPeepggvrnwdyrfcWLRDSTLTLGALLsagy-------leeAEAW 287 Streptomyces coelic...
1AYX_A 84 DNNFNTTLAKAVEY-YINTSYNLQRTSNPSGSFDDEnhkGLGEPKFNTDGSAYTGA--WGRPQNDGPALRAYAISRYlnd 160 Saccharomycopsis fi... Q9W391 74 CYELEQSCVKLMRG-LLMAMMNQKDKVEKFKMTQSPy-dSLHAKYSSKNGLPVVDDneWGHLQIDAVSLYLLILAQM--- 148 fruit fly Q9VLS1 112 SYELGQSTVKCMRG-ILECWVKQASRVELFKQRQSNq-hALHSKFQLHTGEKIYPDefYNHLQIDCVSLYLLFLVQM--- 186 fruit fly Q8YW30 77 TYELEHSVIKLMRG-LLFAMMRQAHKVEQFKQTQSPl-dGLHAKYNTATGDIVVGDdeWGHLQLDATSIFLLMLAQM--- 151 Nostoc sp. PCC 7120 Q97V93 279 INFLLSLINFSSKP-FYYPLYTIEGT-IPPPERELR-----WLSGYKNSKPVRIGNgaSSQIQLDIEGFFISALYKYv-- 349 Sulfolobus solfatar... Q10211 327 MSFIYHVLKKKNKDgGINIVYSIHGDSQNLEEVELT-----HLRGYYNSHPVRIGNaaVHHLQLDIYGELMDSIYIY--- 398 Schizosaccharomyces... Q9HLE2 275 LYDMMDVISRENK---IRTIYSIDNS-DDFVEREL------DFEGYRGSRPVRIGNkaVDQLQIDQYGSIVRAIHAM--- 341 Thermoplasma acidop... Q9KYJ7 294 RRWLLRAVAGDPEN--LQIMYGITGD-RDLRERELP-----WLPGYEGSSPVRVGNgaADQLQLDVYGEVIDTLYLA--- 362 Streptomyces coelic... Q9S223 303 REWLLRAVAGDPEN--LQIMYGIAGE-RELGEAELD-----WLPGYEGSGPVRVGNgaAHQLQLDVYGEVTEALHLG--- 371 Streptomyces coelic... Q9RJ38 288 RDWLLRAVAGNPAD--LQIMYGVAGE-RRLPEYELP-----WLSGFAGSAPVRIGNdaVNQLQLDVYGEVMDSLSLA--- 356 Streptomyces coelic...
1AYX_A 161 vnsLNEGklvltdsgdINFSSTEDIYkniIKPDLEYVIGYWDSTGFDLWE----ENQGRHFF--TSLVQQKALAYAVDIA 234 Saccharomycopsis fi... Q9W391 149 ---TASG---------LQIVFSLDEVs-fIQNLVFYIESAYSIPDYGIWErgdkTNHGEPELnaSSIGMAKAALEAMNEL 215 fruit fly Q9VLS1 187 ---ITSG---------LQIIYTHDEVa-fVQNLVYYVERAYRTPDFGMWErgskYNNGTPEIhaSSIGMAKSALEAINGC 253 fruit fly Q8YW30 152 ---TASG---------LQIIYTIDEVn-fVQNLVYYIGRAYRTPDYGIWErgnkINHGNAELnaSSVGMAKAALEAMNEL 218 Nostoc sp. PCC 7120 Q97V93 350 --kMTND---------QVFLKDVFSK---VKYIGDWISENWSLKDSGIWE----DRGSPQHYthSKIMMWIALDKIGKLA 411 Sulfolobus solfatar... Q10211 399 ---DKKC---------QPIAYDLWLE---VRQICDYVCANWKRPDKSIWE----VRGQERNFlySKIMLWVALDRALRIA 459 Schizosaccharomyces... Q9HLE2 342 ---EKAG---------GVVNSYLWDF---VEEMMAKIEYLWKYPDSSIWE----FRTEPKQYvySKVMSWAAFDSAITMA 402 Thermoplasma acidop... Q9KYJ7 363 ---YQSG---------VAHCADTAVL---HRQLIQHLARRWREPDEGIWE----IRGARRHFvhSKVMAWVAVDRTIRLA 423 Streptomyces coelic... Q9S223 372 ---HMTG---------LARNDYASVL---QLKLIRYLEDHWNEPDEGIWE----VRGPRRHFvhSKVMAWVAVDRTIKLI 432 Streptomyces coelic... Q9RJ38 357 ---RLAG---------MRPRPQMWEL---QCALMEFLATAWREPDEGLWE----VRGGRRQFvhSKVMTWVALDRAVRTL 417 Streptomyces coelic...
1AYX_A 235 KSFDDGD-------------------------------------------------FANT--LSSTASTLESYLSGsdG- 262 Saccharomycopsis fi... Q9W391 216 DLFGARGgpasvihvladeahkcqavlqsmlpresnskeldsgllcvigfpafavdDAQL--IHNTKDAILSRLQGkyGc 293 fruit fly Q9VLS1 254 NLFGEKGaswsvvyvdidahnrnrsifetmlpressskgvdasllltlsfpafashEDRL--VEQTKQNVVNRLRCkmGf 331 fruit fly Q8YW30 219 DLFGVRGsqasvihvlpdeiartrstlesllpresaskeidaallsiisypafaveDAQL--RERTLNEIINKLQGkyGc 296 Nostoc sp. PCC 7120 Q97V93 412 NLIG----------------------------------------------------YADI--WAKEREKLRNWIf--tNc 435 Sulfolobus solfatar... Q10211 460 FTRSLPC-------------------------------------------------PKHMv-WMDTRDEIYEAImd---- 485 Schizosaccharomyces... Q9HLE2 403 RDLGLTA-------------------------------------------------PIKK--WKGIQDEIWNDVmt---- 427 Thermoplasma acidop... Q9KYJ7 424 EAGALDM-------------------------------------------------DVAP--LVELRAAIHREVcd---- 448 Streptomyces coelic... Q9S223 433 ESGDADG-------------------------------------------------PLER--WKQLRDDIHRDVce---- 457 Streptomyces coelic... Q9RJ38 418 EDRPELG-------------------------------------------------GGDLdgWRALRDEVHREVce---- 444 Streptomyces coelic...
1AYX_A 263 ------GF--------------------------VNTDVNHIVENPDll-----qQNSRQGLDSAT-------------- 291 Saccharomycopsis fi... Q9W391 294 krflrdGYrtpkedpsrlyyerwelrmfenieceWPLFYCYLILFHAfqsdkravEEYASRLEKIMvrse-------dgi 366 fruit fly Q9VLS1 332 krftrdGFlsknedksrryyhsgelkefegleceWPLFFIAMIIDGVfknnneqiEEFQNDLRRCLrtd--------vng 403 fruit fly Q8YW30 297 krflrdGHqtvledtqrlhyepwelkqfehieceWPLFFTYLALDGLfcddskqaQFYQEQLEKLLierdgvsanighsl 376 Nostoc sp. PCC 7120 Q97V93 436 v-----------------------------------kNNYFIRYCGN-----------TDDVDSSL-------------- 455 Sulfolobus solfatar... Q10211 486 -----sGY--------------------------NMEKGFFAQSFEN-----------NDILDASV-------------- 509 Schizosaccharomyces... Q9HLE2 428 -----kGF--------------------------DPQTNSFVQYYGS------------KNVDASL-------------- 450 Thermoplasma acidop... Q9KYJ7 449 -----kGF--------------------------DPVRNTFTQAYGS------------QELDAAT-------------- 471 Streptomyces coelic... Q9S223 458 -----kGY--------------------------DKERNTFTQSYGS------------QALDASL-------------- 480 Streptomyces coelic... Q9RJ38 445 -----kGY--------------------------DPVRNTFTQYYGS------------RELDASV-------------- 467 Streptomyces coelic...
1AYX_A 292 YIGPLLTHDIGESsstpf----------dvdnEYVLQSYYLLLED-NKDRYSVNSAYSAGAaIGR-YPEDVYN------- 352 Saccharomycopsis fi... Q9W391 367 LLVPESYAVPQDLvgfeyqkpgsqvrevvgrcPFLWGQSLFILGR-LLQEGFLAVGELDPL-NRR-LGAQKKPdvvvqvv 443 fruit fly Q9VLS1 404 DPVVTMYYAPDGDgsymr---------apsqsLFLWGQSFFIIAQ-LLTAGLLHINELDP--IRRyLPSYNRPrragrys 471 fruit fly Q8YW30 377 RLLPELYYVPAENveaeklapqtqprlpnenvPLVWAQSLYYLGQ-MLSEGLLAVGDVDPL-GRH-LTIGKKRealvqiv 453 Nostoc sp. PCC 7120 Q97V93 456 LSAPLYGFIEVSD-------------------STFINTLTKIEND-LKTDVF----------VKR-YKTDF--------- 495 Sulfolobus solfatar... Q10211 510 LVMPLVSFISPTD-------------------PRFLSTMDNIMKP-LEKDGLMSNGL-----IFR-YNNFVYE------- 556 Schizosaccharomyces... Q9HLE2 451 LRLPILGFIPAND-------------------ERFIGTMKRIEDE-LMVDGYL---------FRR-YRED---------- 490 Thermoplasma acidop... Q9KYJ7 472 LLIPRTGFLPPDD-------------------PRVIGTVDAVRRE-LSTD----DGL-----VYR-YPTCSEDag----- 516 Streptomyces coelic... Q9S223 481 LLIPQMGFLPPDD-------------------KRVIGTIEAIQRElSTSDGF----------ILR-YPTDGEAeg----- 525 Streptomyces coelic... Q9RJ38 468 LLIPRVGFLPPDD-------------------PRVVGTVDAIGAE-LARDGL----------VRR-YSTEGDPv------ 510 Streptomyces coelic...
1AYX_A 353 ------------------------------------------------------------GDGSSEGNPW---------- 362 Saccharomycopsis fi... Q9W391 444 iiaedneirdklaehdlhvq--------------tiaevapievqparvlshlytylgrnRKLGLSGRKSrdvgilstsk 509 fruit fly Q9VLS1 472 afqgtatdlvvqivliaesmrlqammatygiqtqtphevepvqiwsstelikvyqhlgvnNKVGLSGRPCrpvgslgtsk 551 fruit fly Q8YW30 454 llaededlqaqlavhgietq--------------tpkqvapiqvrqaselstiytqigrnDKLGLTGRPVrrlrslttsr 519 Nostoc sp. PCC 7120 Q97V93 496 --------------------------------------------------------------MGEAKHPF---------- 503 Sulfolobus solfatar... Q10211 557 ------------------------------------------------------------DGVGGDEGAF---------- 566 Schizosaccharomyces... Q9HLE2 491 ------------------------------------------------------------DGLKGDEGSF---------- 500 Thermoplasma acidop... Q9KYJ7 517 -----------------------------------------------------------aDGLTGDEGAF---------- 527 Streptomyces coelic... Q9S223 526 -----------------------------------------------------------vDGLPGDEGAF---------- 536 Streptomyces coelic... Q9RJ38 511 ------------------------------------------------------------DGLPGGEGTF---------- 520 Streptomyces coelic...
1AYX_A 363 ---------------------------------------FLATAY----------------------------------- 368 Saccharomycopsis fi... Q9W391 510 lyslkdrifaftpqfadlsrfyiasdnelmidilkgeinFLKSAWdllgrplvtlvlkrihldqdkiplamiqtmrklks 589 fruit fly Q9VLS1 552 vyricgmtvlcyplifevsdfylyrdmalliddiktelqFVGKYWrlsgrptvcllireehmrdpqfkemldllamlkkg 631 fruit fly Q8YW30 520 vfrlrgetivflpsfldsqqfyltldyhflvdqirselaYIQKYWsdlgrpiltlmlthtmletgsqallelmqelkdgv 599 Nostoc sp. PCC 7120 Q97V93 504 ---------------------------------------LLTTVW----------------------------------- 509 Sulfolobus solfatar... Q10211 567 ---------------------------------------TMVCFW----------------------------------- 572 Schizosaccharomyces... Q9HLE2 501 ---------------------------------------LMLTFW----------------------------------- 506 Thermoplasma acidop... Q9KYJ7 528 ---------------------------------------FLCAFW----------------------------------- 533 Streptomyces coelic... Q9S223 537 ---------------------------------------LACSFW----------------------------------- 542 Streptomyces coelic... Q9RJ38 521 ---------------------------------------LVCSFW----------------------------------- 526 Streptomyces coelic...
1AYX_A -------------------------------------------------------------------------------- Saccharomycopsis fi... Q9W391 590 gyingtrvmlgslkdflntsaitdlsflgstedgypdrlhpdvqtyldehllrsfsnrstmnlrggqlrprtlrrrmsck 669 fruit fly Q9VLS1 632 ycdgmkvrigrlqnlisssciehldfmnqsdltdnenaf----------------------------------------- 670 fruit fly Q8YW30 600 cngvavklgrlnqlmltgaiqridflqdvefyqsavqd------------------------------------------ 637 Nostoc sp. PCC 7120 Q97V93 -------------------------------------------------------------------------------- Sulfolobus solfatar... Q10211 -------------------------------------------------------------------------------- Schizosaccharomyces... Q9HLE2 -------------------------------------------------------------------------------- Thermoplasma acidop... Q9KYJ7 -------------------------------------------------------------------------------- Streptomyces coelic... Q9S223 -------------------------------------------------------------------------------- Streptomyces coelic... Q9RJ38 -------------------------------------------------------------------------------- Streptomyces coelic...
1AYX_A -------------------------------------------------------------------------------- Saccharomycopsis fi... Q9W391 670 gaikktrsinvdsdnlgmegpsplterrlssivpppwlqankqshvsvfattpeegptssplslgndlireniypvdphh 749 fruit fly Q9VLS1 -------------------------------------------------------------------------------- fruit fly Q8YW30 -------------------------------------------------------------------------------- Nostoc sp. PCC 7120 Q97V93 -------------------------------------------------------------------------------- Sulfolobus solfatar... Q10211 -------------------------------------------------------------------------------- Schizosaccharomyces... Q9HLE2 -------------------------------------------------------------------------------- Thermoplasma acidop... Q9KYJ7 -------------------------------------------------------------------------------- Streptomyces coelic... Q9S223 -------------------------------------------------------------------------------- Streptomyces coelic... Q9RJ38 -------------------------------------------------------------------------------- Streptomyces coelic...
1AYX_A -------------------------------------------------------------------------------- Saccharomycopsis fi... Q9W391 750 srsaidrrsefvrqqempkiliqrhraetnfadteveeliamlretenleeqgdilqylvdtqgldfntaglgfknksee 829 fruit fly Q9VLS1 671 -------------------------sqinheyigyqsltdvpkaltyveekisvahfdtkptpdiinalrstdsiyclcq 725 fruit fly Q8YW30 638 -------------------------agkrcyylayhpgknwrlghsqefqveyetnldfllsslrasenlyeqiellqtl 692 Nostoc sp. PCC 7120 Q97V93 -------------------------------------------------------------------------------- Sulfolobus solfatar... Q10211 -------------------------------------------------------------------------------- Schizosaccharomyces... Q9HLE2 -------------------------------------------------------------------------------- Thermoplasma acidop... Q9KYJ7 -------------------------------------------------------------------------------- Streptomyces coelic... Q9S223 -------------------------------------------------------------------------------- Streptomyces coelic... Q9RJ38 -------------------------------------------------------------------------------- Streptomyces coelic...
1AYX_A 369 ------------------AAQVPYKLAYDAKSASNdITINKINYDFFNKYIVDlsti--------nsayQSSDSVTiksg 422 Saccharomycopsis fi... Q9W391 830 natpnannagmleegrvvTVRDLLKGLYEKACQQKlWGLVRHTAGMLGKRVEDlakavtdl-lvrqkqvTVGMPPN---- 904 fruit fly Q9VLS1 726 lwgiilnregphfevnglNVNTALTQLYHRAGSLRyWRAVRYCSSLLHHIVDSispfittv-lvngkelTVGIIGQ---- 800 fruit fly Q8YW30 693 trlqglefdtgfgtnqrvTVADLLDEVYTKAGELGfWAVVRRAAG-LRQMVDIgltdavtsilirgkqiAVGRAYS---- 767 Nostoc sp. PCC 7120 Q97V93 510 -----------------------LARVYMRLGK------IDSAIEILNKINKV--------------------------- 533 Sulfolobus solfatar... Q10211 573 -----------------------LVEALAMAGCSGyPKLLSTAVSMFEDLVRY--------------------------- 602 Schizosaccharomyces... Q9HLE2 507 -----------------------YIEDLILMKR------LKAARAALESIIEK--------------------------- 530 Thermoplasma acidop... Q9KYJ7 534 -----------------------FVDGLALTGR------LDEARALFERLLAL--------------------------- 557 Streptomyces coelic... Q9S223 543 -----------------------MADDLAMIGR------VDEARKLFEKLLSL--------------------------- 566 Streptomyces coelic... Q9RJ38 527 -----------------------YADALHATGR------TKEARELFERLVGL--------------------------- 550 Streptomyces coelic...
1AYX_A 423 SDEFNTVADNLVTFGDSFLQVILDhINDDGSLNEQLNRYTGYSTGAYSLTWSSGALLEAIR 483 Saccharomycopsis fibuligera Q9W391 905 NEHTITAPLPEVELRQLIHDAYGD-DESTAMLTQELMVYLAMFIRTEPQLFHEMLRLRVGL 964 fruit fly Q9VLS1 801 KETVFDKPMTPAEIQNVMYTSVQPyDVIQAVLQQEVVLYCGRLIATNPSMFRGILKIRIGW 861 fruit fly Q8YW30 768 EASLISVPMPHNEIADKINHFCRE-DIRDRVLTQEVLIYLGILIRSQTESFQGLLTLRVGY 827 Nostoc sp. PCC 7120 Q97V93 534 -------------------------SRELHLVGEHVDVEKGEFTGNFPQIFVHAQLVIAIK 569 Sulfolobus solfataricus Q10211 603 -------------------------SSHLQYYSEECSL-SSESLGNSPQAFSSIAAIAAAH 637 Schizosaccharomyces pombe 972h- Q9HLE2 531 -------------------------ANHLGLYSEEIDEKTGDFLGNFPQALSHLGIIRVAP 566 Thermoplasma acidophilum Q9KYJ7 558 -------------------------RNDLGLLAEEYDPVQQRQLGNFPQAFSHMGLIQSAL 593 Streptomyces coelicolor Q9S223 567 -------------------------RNDLGLLAEEWDPRLQRQVGNFPQAFSHVPLIDTAL 602 Streptomyces coelicolor Q9RJ38 551 -------------------------ANDVGLLAEEYDPVAGHQLGNFPQAFSHVGLVNTAL 586 Streptomyces coelicolor
Jiyao W et al.(2023). "The conserved domain database in 2023.",