Conserved Protein Domain Family
wnt
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pfam00110: wnt (this model, PSSM-Id:278536 is obsolete and has been replaced by 459677)
wnt family
Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.
Links
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Statistics
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PSSM-Id: 278536
Aligned: 195 rows
Threshold Bit Score: 258.648
Created: 10-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q17NQ4        42 GTR--RQNHQCRRDTGLPDAIKEARRLAVTHCEEQFRYDRWNCSIEt------------------------rGKRN--IF 93  yellow fever mo...
CDS34055      98 LSN--HQRNLCRSNPGLIWALVDGTQLGLYECVHQFKYDKWNCSmarvvlgkprgeafllngdkssaanligSLQK--TL 173 Hymenolepis mic...
CDJ02649     101 LSN--HQRNLCRRNPGLIWALIDGTQLGLYECVHQFKHERWNCSmarvilgrpqsealplskdpspttnligELQK--TL 176 Echinococcus mu...
XP_003384323  49 LNS--SQQTFCNYNRKIVNSIAIGTRRGIVACQQNFANWRWNCTTFtg----------------------enLFGA--FV 102 Amphimedon quee...
XP_003213045  34 LSR--KQKRLCRREPGLAETLRDAIRLGIMECQFQFRSERWNCSLEg--------------------------RTS--LL 83  turkey
XP_002945358  34 LTR--RQRRLCRKEPGLAEALREAVRLGVVECQFQLRSERWNCSLQe--------------------------RGN--LL 83  western clawed ...
XP_003768486 128 LSR--KQKQLCRREPGLAETLYDAVHLGVLECQAQFRHERWNCSLEg--------------------------RTA--LL 177 Tasmanian devil
NP_001131132  62 LTR--RQKRLCRREPGLAETLRESVRLSLLECRYQFRNERWNCSMDg--------------------------RGS--LL 111 zebrafish
XP_005998639  63 VSR--KQKRLCRREPGLAETLRDSVRLSLLECQYQFRNERWNCSLDg--------------------------RAS--LL 112 coelacanth
XP_002407191  52 hrKeaRLRRFCSVDPGLVQAIVHGTRLTVDSCQSLFQWEPWQCDLL--------------------------QDKRrhLL 105 black-legged tick

Q17NQ4        94 KKVYRETAFVHALTAAAITYSVARACAEGKMAK-CQCASEKRPEATR----LAWKWGGCSDNIKHGKRVTRNFLELQPad 168 yellow fever mo...
CDS34055     174 MKSTRETAFVTAAWAAGAVQAVTRACSRGRIST-CDCDVTRRGGLKAadteGPFTWGGCSDPIRFGMRLVRLFQEPRLps 252 Hymenolepis mic...
CDJ02649     177 EKGTRETAFVTAAWAAGAVQAVTRACSRGRIST-CDCDISRHGGLKAadseGAFTWGGCSDPIRFGMRLVRLLQEPRIts 255 Echinococcus mu...
XP_003384323 103 KNNTRETAVINALLTAGAERQIALDCRDEKLPN-CTCqingdng-vvnstfFLYE---CSFDIAKAHDIMSKFLETPSnd 177 Amphimedon quee...
XP_003213045  84 KRGFKETAFLYAVSSAALTHSLARACSAGRMER-CTCDDS-PDLENR----KAWQWGVCGDNLKYSTKFLKKFLGQKRig 157 turkey
XP_002945358  84 KRGFKETAFMYAISAASLTHSVAKACSGGRMER-CTCDDS-QGPESQ----QAWQWGVCGDNLRHSTRFLQNFLRQKKgg 157 western clawed ...
XP_003768486 178 KRGFKETAFLYAVSSAALTHALARACSAGRMER-CTCDDS-PDLENR----QAWQWGVCGDNLKYSTKFLSNFLGPKKgs 251 Tasmanian devil
NP_001131132 112 KRGFKETAFLLAVSSAALSHALAKACSSGRMER-CTCDDS-PGLQHR----EAWQWGVCGDNLKYSTKFLKKFLGQKRvs 185 zebrafish
XP_005998639 113 KRGFKETAFLYAVSSAALTHSLAKACSSGRMER-CTCDDS-PDLENR----EAWQWGVCGDNLKYSTKFLKNFLGQRRis 186 coelacanth
XP_002407191 106 KKVYRETALVYALAAAGLTHSVARGCSSGRLSSrCSCNESGSRTLSAtesdQNWKWGGCGDNYSFSAKFSRKLLARNKsr 185 black-legged tick

Q17NQ4       169 g-------------------------------dpVAEM---LRHDSEVGIQAVTSTMNDRCKCHGVSGSCSLKTCWRKLG 214 yellow fever mo...
CDS34055     253 sknksrrkkqrskh----nlnggendtiidvddsRILM---DIHNQKVGRRFVWQSREKKCKCHGVSGACSLRTCWQRTG 325 Hymenolepis mic...
CDJ02649     256 amgadnrrrlrlhalggkksdtreekksdddimaRCLI---DVHNQKVGRRFIWQSREKKCKCHGISGACTLRTCWQRVG 332 Echinococcus mu...
XP_003384323 178 ---------------------------------dtAII---AEHNHNVGSNLVGQRYRK-CRCTGFSGSCSVQTCYFASP 220 Amphimedon quee...
XP_003213045 158 k-------------------------------dlRAKV---DIHNTNVGIKAVKNGLKTTCKCHGVSGSCAVRTCWKQLS 203 turkey
XP_002945358 158 r-------------------------------dsRAKM---DLHNSNAGIKAVKSGLKTTCKCHGVSGSCAVRTCWKQLS 203 western clawed ...
XP_003768486 252 k-------------------------------dlRARM---DAHNTNMGIKAVRNGLKTTCKCHGVSGSCAVRTCWKQLS 297 Tasmanian devil
NP_001131132 186 k-------------------------------dlRAQI---DAHNINVGIRAVKSGLKTTCKCHGVSGSCAVRTCWKQLS 231 zebrafish
XP_005998639 187 k-------------------------------dlRARV---DMHNTNVGVKAVKSGLKTTCKCHGVSGSCAVRTCWKQLS 232 coelacanth
XP_002407191 186 --------------------------------rpRTLRrpvDNHNLVVGIRVLRHGIRRVCKCHGLSGSCSAKTCWEELA 233 black-legged tick

Q17NQ4       215 DFNATAAMLRTKYHHAIrkIpinnktsrraipkEF-------------REREGs-------------------------- 255 yellow fever mo...
CDS34055     326 PFRGVGDLLKRAYLTSLq-VafdtstrqlirqaDPlffggmplppghlTKRSAnwfiagggekttpwqrikresefgenw 404 Hymenolepis mic...
CDJ02649     333 TFRGVGDLLKKAYSNALq-VsfdaatrqlrrlaDPlyfggmplpaghlMKRSTswfvgsnggnllawqrrrretqfgekw 411 Echinococcus mu...
XP_003384323 221 DIDTIGQRVREKYGSSVe-VtvnasnsalqpvvQT-------------INNHD--------------------------- 259 Amphimedon quee...
XP_003213045 204 PFHEVGRLLKLRYDDAVk-VfsttndavghselASpqrhshst---------------------------------khha 249 turkey
XP_002945358 204 PFHETGALLKAKYENAIk-IhgasnkavgghesLGhtfgg---------------------------------------r 243 western clawed ...
XP_003768486 298 PFRETGQLLKLRYDSAVk-VsstsnealgrlelWApprpghpv----------------------------------kgt 342 Tasmanian devil
NP_001131132 232 PFQDTGHLLKYRYDTAVr-VhsvtnsatgetelAGprrhsit------------------------------------lp 274 zebrafish
XP_005998639 233 PFHETGKLLKHKYETAIk-VfsvtndatgeaelVSpkkhshsl----------------------------------khh 277 coelacanth
XP_002407191 234 HFPDVAKALKRKYSKAI--MaqvenkpdfasteVV-------------SKLKKtlltrttqkpkw-------lravtael 291 black-legged tick

Q17NQ4       256 ----YDqLFYFETSPTFCSV--------TRGRRC----L-HPDNCATLCCGRGYTTKVVKTIEKCRCRFTngRCCQIVCD 318 yellow fever mo...
CDS34055     405 ikrqKDkLVFLDYSPDYCKAdskighlgVSGRQCevdkPnSPNSCDKICCGRGYDIFEVDTKEKCNCKFV--WCCEVKCS 482 Hymenolepis mic...
CDJ02649     412 ikrqKDkLVYLDYSPDYCKAdhrighfgVAGRQCdvdiPnSPNSCSKICCGRGYDTFEVDTKEKCGCKFV--WCCEVKCK 489 Echinococcus mu...
XP_003384323 260 ----NE-LVYLKRSPTFCNQdttygilgTVGRQCsnnlS-DPDSCDIICCGRGHITVTATQPKQC-CSFI--YCCRIECQ 330 Amphimedon quee...
XP_003213045 250 spraTD-LVYVEDSPSFCRPsky--slgTAGRTCsregN-----CDSMCCGRGYNTQSRLVTFSCHCQVQ--WCCYVECQ 319 turkey
XP_002945358 244 harsTD-FLYLEESPNFCRPsrf--spgMAGRTClrenT-----CDSLCCGRGYNIQTRMVTFSCHCQVH--WCCHVECQ 313 western clawed ...
XP_003768486 343 aprpGD-LVYIDDSPSFCRPsky--spgTAGRTCsreaS-----CDSLCCGRGHNTQSRLVAFSCHCHVQ--WCCYVECQ 412 Tasmanian devil
NP_001131132 275 rprpTE-LVFLEESPSFCRPsry--spgTAGRPCskdtS-----CSSLCCGRGYNTALRLTTLSCHCQVR--WCCHVECQ 344 zebrafish
XP_005998639 278 sprsTD-LVYMEDSPSYCRTgky--spgTAGRICsketN-----CDSMCCGRGYNTQSRVVKFSCHCQVQ--WCCYVECQ 347 coelacanth
XP_002407191 292 qrlgRDrLVYLEESPSFCERnvl--tggMSQRRCrdhaH-----CEQVCCGRGHRSFSETVQERCHCRVV--WCCQLECK 362 black-legged tick

Q17NQ4       319 YCEKYED-RYYCK 330 yellow fever mosquito
CDS34055     483 VCHRKSR-IYRCK 494 Hymenolepis microstoma
CDJ02649     490 MCHRKDR-INRCK 501 Echinococcus multilocularis
XP_003384323 331 DCGEETFtEYFCK 343 Amphimedon queenslandica
XP_003213045 320 QCMQEEV-VYSCK 331 turkey
XP_002945358 314 KCVQQQE-TYTCK 325 western clawed frog
XP_003768486 413 QCVQEEL-AYTCK 424 Tasmanian devil
NP_001131132 345 TCLREEE-VYTCK 356 zebrafish
XP_005998639 348 QCMQEEE-VYTCK 359 coelacanth
XP_002407191 363 TCTVLKY-SHSCh 374 black-legged tick
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