1S8F,4PHH,3CPJ,1Z0A,2BME,3QBT,1G16,4RKF,1UKV,1EK0,3ICQ,2RAP,2FN4,1UAD,1TU3


Conserved Protein Domain Family
Ras
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pfam00071: Ras (this model, PSSM-Id:278499 is obsolete and has been replaced by 425451)
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Ras family
Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.
Links
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Statistics
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PSSM-Id: 278499
Aligned: 61 rows
Threshold Bit Score: 178.081
Created: 10-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1S8F_A        11 KVILLGDGGVGKSSLMNRYVTNKFDTQLFHTIgVEFLNKDLEVDGHFVTMQIWDTAGQERFRSLRTPFYRGSDCCLLTFS 90  dog
P32253         6 KLVIVGDGGVGKSALTIQLTQNQFIAEYDPTI-ENSYRKQVNIDEEVYMLDILDTAGQEEYSAMRDQYIRSGRGFLIVYS 84  Dictyostelium d...
P22126        10 KLVVVGGGGVGKSCLTIQLIQGHFLDEYDPTI-EDSYRKQCTIDNEVALLDILDTAGQEEYSAMREQYMRTGEGFLLVFA 88  Neurospora cras...
2FN4_A        11 KLVVVGGGGVGKSALTIQFIQSYFVSDYDPTI-EDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFA 89  human
P04388         7 KLVVVGGGGVGKSAITIQFIQSYFVTDYDPTI-EDSYTKQCNIDDVPAKLDILDTAGQEEFSAMREQYMRSGEGFLLVFA 85  fruit fly
P01120        12 KLVVVGGGGVGKSALTIQLTQSHFVDEYDPTI-EDSYRKQVVIDDEVSILDILDTAGQEEYSAMREQYMRNGEGFLLVYS 90  Saccharomyces c...
P32254         5 KLVLVGPGGVGKSCLTIQFIAQKFVDEYDPTL-EDSYRKQTTVDGEECLLDIYDTAGQEDFSAVRDQYMRTGEGFLCVYS 83  Dictyostelium d...
1UAD_B         8 KVIMVGSGGVGKSALTLQFMYDEFVEDYEPTK-ADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFS 86  human
P25378        18 KIALIGARNVGKTTLTVRFVESRFVESYYPTI-ENEFTRIIPYKSHDCTLEILDTAGQDEVSLLNIKSLTGVRGIILCYS 96  Saccharomyces c...
XP_003291742   5 klvivggggvgKSALTIQLIQNHFIDEYDPTI-EDSYRKQVTIDEETCLLDILDTAGQEEYSAMRDQYMRTGQGFLCVYS 83  Dictyostelium p...

1S8F_A        91 VDDSQSFQNLSNWKKEFIYYADvkepEs-FPFVILGNKIDIS------ERQVSTEEAQAWC-------RDNGdYPYFETS 156 dog
P32253        85 IISRASFEAVTTFREQILRVKDl--sT--YPIVIIGNKADLPd----kDRKVPPMEGKELA-------KSFG-APFLETS 148 Dictyostelium d...
P22126        89 INSRESFEEIRIYQQQILRVKDr--dS--FPMIIVGNKYDLRg-----ERVVSEQEGQALA-------AEFG-TKYIETS 151 Neurospora cras...
2FN4_A        90 INDRQSFNEVGKLFTQILRVKDr--dD--FPVVLVGNKADLEs-----QRQVPRSEASAFG-------ASHH-VAYFEAS 152 human
P04388        86 LNDHSSFDEIPKFQRQILRVKDr--dE--FPMLMVGNKCDLKh-----QQQVSLEEAQNTS-------RNLM-IPYIECS 148 fruit fly
P01120        91 ITSKSSLDELMTYYQQILRVKDt--dY--VPIVVVGNKSDLEn-----EKQVSYQDGLNMA-------KQMN-APFLETS 153 Saccharomyces c...
P32254        84 ITYLQSFKEIHRLHNHLLKVKDl--dS--VPFVLVGNKCDLNe-----YREVSTAEGEELA-------KKLN-CKFLETS 146 Dictyostelium d...
1UAD_B        87 ITEMESFAATADFREQILRVKEd---En-VPFLLVGNKSDLEd-----KRQVSVEEAKNRA-------EQWN-VNYVETS 149 human
P25378        97 IINRASFDLIPILWDKLVDQLGk--dN--LPVILVGTKADLGrstkgvkRCVTKAEGEKLAstigsqdKRNQ-AAFIECS 171 Saccharomyces c...
XP_003291742  84 ITSRSSFDEIASFREQILRVKD----KdrVPMIVVGNKCDLEs-----DRQVTTGEGQDLA-------KSFG-CPFLETS 146 Dictyostelium p...

1S8F_A       157 AKDATNVAAAFEEAVRRVLA 176 dog
P32253       149 AKSRVNVEEAFFTLVREIKR 168 Dictyostelium discoideum
P22126       152 AKTQHNVENAFYDLVREIRK 171 Neurospora crassa OR74A
2FN4_A       153 AKLRLNVDEAFEQLVRAVRK 172 human
P04388       149 AKLRVNVDQAFHELVRIVRK 168 fruit fly
P01120       154 AKQAINVEEAFYTLARLVRD 173 Saccharomyces cerevisiae S288c
P32254       147 AKERINVSESFYELVREVKK 166 Dictyostelium discoideum
1UAD_B       150 AKTRANVDKVFFDLMREIRA 169 human
P25378       172 AELDYNVEETFMLLLKQMER 191 Saccharomyces cerevisiae S288c
XP_003291742 147 AKIRVNVEEAFYSLVREIRK 166 Dictyostelium purpureum
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