2ASI,2APR,1EPL,3FV3,3Q70,1J71,1AVF,4GJ5,1TZS,1PSO,1IBQ


Conserved Protein Domain Family
Asp
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pfam00026: Asp (this model, PSSM-Id:278455 is obsolete and has been replaced by 394983)
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Eukaryotic aspartyl protease
Aspartyl (acid) proteases include pepsins, cathepsins, and renins. Two-domain structure, probably arising from ancestral duplication. This family does not include the retroviral nor retrotransposon proteases (pfam00077), which are much smaller and appear to be homologous to a single domain of the eukaryotic asp proteases.
Links
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Statistics
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PSSM-Id: 278455
Aligned: 26 rows
Threshold Bit Score: 262.603
Created: 10-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2ASI_A    19 EYAIPVSIGTPGQDFLLLFDTGSSDTWVP---HKGC-------------------TKSe--------------------- 55  Mucor miehei
2APR_A    16 EYYGQVTIGTPGKKFNLDFDTGSSDLWIA---STLC-------------------TNC---------------------- 51  Rhizopus microsporu...
1EPL_E    16 AYITPVQIGTPAQTLNLDFDTGSSDLWVF---SSET-------------------TAS---------------------- 51  chestnut blight fungus
P32834    75 GYFANLTLGSNERVYSLTLDTGSPYTWVT---AKNI-------------------TALsaseiwsdtdgvdagrstsdir 132 Schizosaccharomyces...
P22929    74 FYLTTIEIGTPGQKLQVDVDTGSSDLWVP----GQG-------------------TSS---------------------- 108 Saccharomycopsis fi...
P32950    74 SYGIRVSVGSNKQEQQVVLDTGSSDFWVVd-sSASC-------------------QKG---------------------- 111 Candida parapsilosis
3FV3_C    13 SYASKVSVGSNKQQQTVIIDTGSSDFWVVd-sNAQC-------------------GKGv--------------------- 51  Candida parapsilosis
3Q70_A    13 TYAADITVGSNNQKLNVIVDTGSSDLWVPd-vNVDC-------------------QVTysdq-----------------t 55  Candida albicans
1J71_A    13 SYAADIVVGSNQQKQTVVIDTGSSDLWVVd-tDAEC-------------------QVTysgq-----------------t 55  Candida tropicalis
AJR48126  44 YYATTLDIGTPSQSLTVLFDTGSADFWVMdssNPFClpnsntssysnatyngeevKPSi--------------------- 102 Saccharomyces cerev...

2ASI_A    56 --GCVGSRFFDPSASSTFKAT-NYN---L-NITYGTGG-ANGLYFEDSIAIGDITVTKQILAYVDNvrgptaeqspnADI 127 Mucor miehei
2APR_A    52 --G-SGQTKYDPNQSSTYQAD-GRT---W-SISYGDGSsASGILAKDNVNLGGLLIKGQTIELAKReaa------sfASG 117 Rhizopus microsporu...
1EPL_E    52 --EVDGQTIYTPSKSTTAKLLsGAT---W-SISYGDGSsSSGDVYTDTVSVGGLTVTGQAVESAKKvss-----sftEDS 120 chestnut blight fungus
P32834   133 tnACTNYTCFDYS-STTARRT-NSStigF-LASYGDNTtVLGYNMVDNAYFAGLTLPGFEFGLATReyd------ssqIS 203 Schizosaccharomyces...
P22929   109 -----LYGTYDHTKSTSYKKD-RSG---F-SISYGDGSsARGDWAQETVSIGGASITGLEFGDATS------------QD 166 Saccharomycopsis fi...
P32950   112 --NCKQYGTFDPHSSTSFKSL-GSS---FrSIGYGDKSsSIGTWGQDTIYLGGTSITNQRFADVTS------------TS 173 Candida parapsilosis
3FV3_C    52 --DCKSSGTFTPSSSSSYKNL-GAA---F-TIRYGDGStSQGTWGKDTVTINGVSITGQQIADVTQ------------TS 112 Candida parapsilosis
3Q70_A    56 adFCKQKGTYDPSGSSASQDL-NTP---F-KIGYGDGSsSQGTLYKDTVGFGGVSIKNQVLADVDS------------TS 118 Candida albicans
1J71_A    56 nnFCKQEGTFDPSSSSSAQNL-NQD---F-SIEYGDLTsSQGSFYKDTVGFGGISIKNQQFADVTT------------TS 118 Candida tropicalis
AJR48126 103 --DCRSMSTYNEHRSSTYQYL-ENGr--F-YITYADGTfADGSWGTETVSINGIDIPNIQFGVAKY-----------ATT 165 Saccharomyces cerev...

2ASI_A   128 FLDGLFGAAYPDNTAMEaey-----gstY--------NTVHVNLYKQGLISSPLFSVYMNTNS--GTGEVVFGGVNNTLL 192 Mucor miehei
2APR_A   118 PNDGLLGLGFDTITTVRg----------V--------KTPMDNLISQGLISRPIFGVYLGKAKngGGGEYIFGGYDSTKF 179 Rhizopus microsporu...
1EPL_E   121 TIDGLLGLAFSTLNTVSpt--------qQ--------KTFFDNAKAS--LDSPVFTADLGYHA---PGTYNFGFIDTTAY 179 chestnut blight fungus
P32834   204 VTPGIIGLS-VAMTITGissddkvvaftP--------PTIVDQLVSANVIDTPAFGIYLNEDV----GELIFGGYDKAKI 270 Schizosaccharomyces...
P22929   167 VGQGLLGIGLKGNEASAqssn----sftY--------DNLPLKLKDQGLIDKAAYSLYLNSEDa-TSGSILFGGSDSSKY 233 Saccharomycopsis fi...
P32950   174 VNQGILGVGRVETESANp---------pY--------DNVPITLKKQGKIKTNAYSLYLNSPGa-ATGTIIFGGVDNAKY 235 Candida parapsilosis
3FV3_C   113 VDQGILGIGYTSNEAVYdtsgr-qttpnY--------DNVPVTLKKQGKIRTNAYSLYLNSPSa-ETGTIIFGGVDNAKY 182 Candida parapsilosis
3Q70_A   119 IDQGILGVGYKTNEAGGs----------Y--------DNVPVTLKKQGVIAKNAYSLYLNSPDa-ATGQIIFGGVDNAKY 179 Candida albicans
1J71_A   119 VDQGIMGIGFTADEAGYn---------lY--------DNVPVTLKKQGIINKNAYSLYLNSEDa-STGKIIFGGVDNAKY 180 Candida tropicalis
AJR48126 166 PVSGVLGIGFPRRESVKg----------YegapneyyPNFPQILKSEKIIDVVAYSLFLNSPDs-GTGSIVFGAIDESKF 234 Saccharomyces cerev...

2ASI_A   193 GGDIAYTD--------VMsr------ygGYYFWDAPVTGITVDGSa----AVRFSRPQA--------------FTIDTGT 240 Mucor miehei
2APR_A   180 KGSLTTVP--------IDn---------SRGWWGITVDRATVGTS------TVASS-FD--------------GILDTGT 221 Rhizopus microsporu...
1EPL_E   180 TGSITYTA--------VSt---------KQGFWEWTSTGYAVGSG------TFKSTSID--------------GIADTGT 222 chestnut blight fungus
P32834   271 NGSVHWVN--------ISss-------dDSTFYSVNLESITVTNS------TSSNN-VQsskrsskdievnttVTLDTGT 328 Schizosaccharomyces...
P22929   234 SGSLATLD--------LVniddegdstsGAVAFFVELEGIEAGSS------SITKTTYP--------------ALLDSGT 285 Saccharomycopsis fi...
P32950   236 SGKLIEEP--------LV----------SDRYLAVNLKSLNYNGD------NSNAG-FG--------------VVVDSGT 276 Candida parapsilosis
3FV3_C   183 SGKLVAEQ--------VT----------SSQALTISLASVNLKGS------SFSFG-DG--------------ALLDSGT 223 Candida parapsilosis
3Q70_A   180 SGSLIALP--------VT----------SDRELRISLGSVEVSGK------TINTDNVD--------------VLLDSGT 221 Candida albicans
1J71_A   181 TGTLTALP--------VT----------SSVELRVHLGSINFDGT------SVSTN-AD--------------VVLDSGT 221 Candida tropicalis
AJR48126 235 SGDLFTFPmvneyptiVD----------APATLAMTIQGLGAQNKsscehETFTTTKYP--------------VLLDSGT 290 Saccharomyces cerev...

2ASI_A   241 NFFIMPSSAASKIVKAALPDAT-Et----Q-QGWVVPCASYQNSKSTISIVM-QKSGSSSDTIEISVPVSKMllpvdqsn 313 Mucor miehei
2APR_A   222 TLLILPNNIAASVARAYGASDN-G-----D-GTYTISCDTS-AFKPLVFSIN-GASFQVSPDSLVFEEFQGq-------- 284 Rhizopus microsporu...
1EPL_E   223 TLLYLPATVVSAYWAQVSGAKS-Ss----SvGGYVFPCSAT--LPSFTFGVG-SARIVIPGDYIDFGPISTGss------ 288 chestnut blight fungus
P32834   329 VYIYLPEDTVESIADQYQGIVS-E-----Y-GYVVIYCDSFSDSDYISFNFGsDADFHVSVNDLVIYRQESTsg------ 395 Schizosaccharomyces...
P22929   286 TLIYAPSSIASSIGREYGTYSY-S-----Y-GGYVTSCDAT--GPDFKFSFN-GKTITVPFSNLLFQNSEGDs------- 348 Saccharomycopsis fi...
P32950   277 TISYLPDSIVNDLANKVGAYLE-Pvg--lGnELYFIDCNANPQGSASFTFDN-GAKITVPLSEFVLQSTANA-------- 344 Candida parapsilosis
3FV3_C   224 TLTYFPSDFAAQLADKAGARLV-Qva--rDqYLYFIDCNTDTSGTTVFNFGN-GAKITVPNTEYVYQNGDGT-------- 291 Candida parapsilosis
3Q70_A   222 TITYLQQDLADQIIKAFNGKLT-QdsngnS--FYEVDCNLS--GDVVFNFSK-NAKISVPASEFAASLQGDDgqp----y 291 Candida albicans
1J71_A   222 TITYFSQSTADKFARIVGAT---Wds--rNeIYRLPSCDLS--GDAVFNFDQ-GVKITVPLSELILKDSDSSi------- 286 Candida tropicalis
AJR48126 291 SLLNAPKVIADKMASFVNASYSeE-----E-GIYILDCPVSVGDVEYNFDFG-DLQISVPLSSLILSPETEGs------- 356 Saccharomyces cerev...

2ASI_A   314 etCMFIILPd--GGNQYIVGNLFLRFFVNVYD-FGNNRIGFAPL 354 Mucor miehei
2APR_A   285 --CIAGFGYg--NWGFAIIGDTFLKNNYVVFN-QGVPEVQIAPV 323 Rhizopus microsporus var. chinensis
1EPL_E   289 -sCFGGIQSs-aGIGINIFGDVALKAAFVVFNgATTPTLGFASK 330 chestnut blight fungus
P32834   396 diCYLALFEg--DTSSYLLGQYFLQYVYSIYD-WDAQKIGLAAL 436 Schizosaccharomyces pombe 972h-
P22929   349 -eCLVGVLSs--GSNYYILGDAFLRSAYVYYD-IDNSQVGIAQA 388 Saccharomycopsis fibuligera
P32950   345 --CVWGLQSsdrqNVPPILGDNFLRHAYAFQLdKETVLSRSGEV 386 Candida parapsilosis
3FV3_C   292 --CLWGIQPsd----dtILGDNFLRHA-YLLYnLDANTISIAQV 328 Candida parapsilosis
3Q70_A   292 dkCQLLFDV----NDANILGDNFLRSAYIVYD-LDDNEISLAQV 330 Candida albicans
1J71_A   287 --CYFGISRnd----anILGDNFLRRAYIVYD-LDDKTISLAQV 323 Candida tropicalis
AJR48126 357 -yCGFAVQp---TNDSMVLGDVFLSSAYVVFD-LDNYKISLAQA 395 Saccharomyces cerevisiae YJM1385
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