Conserved Protein Domain Family
FYVE_FYCO1
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cd15726: FYVE_FYCO1 
FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins
FYCO1, also termed zinc finger FYVE domain-containing protein 7, is a phosphatidylinositol 3-phosphate (PtdIns3P or PI3P)-binding protein that is associated with the exterior of autophagosomes and mediates microtubule plus-end-directed vesicle transport. It acts as an effector of GTP-bound Rab7, a GTPase that recruits FYCO1 to autophagosomes and has been implicated in autophagosome-lysosomal fusion. FYCO1 also interacts with two microtubule motor proteins, kinesin (KIF) 5B and KIF23, and thus functions as a platform for assembly of vesicle fusion and trafficking factors. FYCO1 contains an N-terminal alpha-helical RUN domain followed by a long central coiled-coil region, a FYVE domain and a GOLD (Golgi dynamics) domain in C-terminus.
Links
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Statistics
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PSSM-Id: 277265
Aligned: 7 rows
Threshold Bit Score: 90.3116
Created: 1-May-2013
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative Znputative
Feature 1: putative Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C C C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens EEA1 (1JOC) binds two Zn2+ ions through its FYVE domain.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #  #            #  #    #  #                #  # 
Q9BQS8       1170 WLGDTeanHCLDCKREFSWMvRRHHCRICGRIFCYYCCNNYvlskhggkkeRCCRACF 1227 human
CAF95847     1228 WLVDKeitHCLDCQSQFTWWlRRHHCRLCGRIFCYYCSNNYvmtkqggkkeRCCKECY 1285 spotted green pufferfish
NP_001039304 1239 WQGDTevnHCLDCQREFSWMvRRHHCRMCGRIFCYYCCNNYmvtkpggrkeRCCKACF 1296 chicken
XP_003197998 1055 EQTDRdvtHCLSCKSQFSWMlRRYNCRFCGRPFCYSCCSFGgk-------dRCCKSCS 1105 zebrafish
ELU16347      216 WMENDsvtHCMDCSLEFSLIrRKHHCRLCGKIFCHACSDNYvmtasssrkeRVCNACL 273  Capitella sp. I Grassle & Grassle, ...
XP_005104668 1473 WQDNSmvtHCPQCNTEFSLFvRKHHCRLCGKIYCWACSDFWldvahsskkaRVCKSCF 1530 California sea hare
ETV77191      276 LVDKVdrtHCCHCLSRFHSWrRKHHCKMCGEVFCWACTQFWrlea---qstRVCVDCA 330  Aphanomyces astaci

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