1EF1,1EVH,1PMS,1RRP,1ZSQ,2NMB,2QKM,3HSA,1MI1,2HTH,2CAY,1TQZ,2GCL,2GCJ,2RNR,4QXA,4GXB,3TW1,3TW1,3U12,2Z59


Conserved Protein Domain Family
PH-like
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cd00900: PH-like 
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Pleckstrin homology-like domain
The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.
Links
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Statistics
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PSSM-Id: 275390
Aligned: 21 rows
Threshold Bit Score: 38.9193
Created: 4-Feb-2003
Updated: 22-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1EF1_A 201 NYFSiknk--------------------------kgsELWLGVDa------lGLNIYEqndr--------------ltpk 234 human
1EVH_A   7 CQARaavmvyddank------------kwvpaggstgFSRVHIYhhtgnntfRVVGRKiqdh---------------qvv 59  house mouse
1PMS_A  34 MEGTltrv-------------------------gakhERHIFLFd------gLMICCKsnhgqprlpg---assaeyrlk 79  house mouse
1RRP_B  25 FCNRaklfrfdve----------------skewkergIGNVKILrhktsgkiRLLMRReqvl---------------kic 73  human
2NMB_A  30 CSFSvkylgcvevfesrgmqvceealkvlrqsrrrpvRGLLHVSg------dGLRVVDdetk---------------gli 88  fruit fly
2HTH_B  21 IQQRgvriydg-------------------eekikfdAGTLLLSt------hRLIWRDqknh---------------ecc 60  human
2CAY_A  33 FIDQsvglyhgk------------------skilqrqRGRIFLTs------qRIIYIDdakp--------------tqns 74  baker's yeast
4QXA_B  14 GKNNvlvqpr---------------------ddmeavPGYLSLHqta--dvmTLKWTPnqlmngsvgdldyeksvywdya 70  house mouse
3TW1_A 156 FHLQchr---------------------------gtkEGTLYFLp------dHIIFGFkk------------------pi 184 Saccharomyces cerevis...
2Z59_A   3 VEFRagkmslkg-----------------ttvtpdkrKGLVYIQqtdd-sliHFCWKDrtsg---------------tve 49  house mouse

1EF1_A 235 IGFPwse-irNISFNd------kKFVIkpidk------------kapdFVFYAprl---riNKRILALC 281 human
1EVH_A  60 INCAipk-glKYNQAtq-----tFHQWrda---------------rqvYGLNFgsk---edANVFASAM 104 house mouse
1PMS_A  80 EKFFmr--kvQINDKddtseykhAFEIilkd--------------gnsVIFSAksa---eeKNNWMAAL 129 house mouse
1RRP_B  74 ANHYisp-dmKLTPNags---drSFVWhaldyad-------elpkpeqLAIRFktp---eeAALFKCKF 128 human
2NMB_A  89 VDQTiek-vsFCAPDrnh---erGFSYicrdgt---------trrwmcHGFLAckdsgerlSHAVGCAF 144 fruit fly
2HTH_B  61 MAILlsq-ivFIEEQaagigksaKIVVhlhpappnkepgpfqssknsyIKLSFke----hgQIEFYRRL 124 human
2CAY_A  75 LGLEldd-laYVNYSsgfltrspRLILffkdps----------sstefVQLSFrk----sdGVLFSQAT 128 baker's yeast
4QXA_B  71 VTIRlee-ivYLHCHqqvd-sggTVVLvsqd-------------giqrPPFRFpkg---ghLLQFLSCL 121 house mouse
3TW1_A 185 LLLDasd-ieSITYSsitr-ltfNASLvtkd--------------gekYEFSXidq---teYAKIDDYV 234 Saccharomyces cerevisiae S288c
2Z59_A  50 DDLIifpddcEFKRVpqcp-sgrVYVLkfka-------------gskrLFFWMqepk-tdqDEEHCRKV 103 house mouse
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