3FBY,1YO8,3FBY


Conserved Protein Domain Family
TSP3
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sd00001: TSP3 
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Calcium-binding Thrombospondin type 3 (TSP3) repeat
TSP3 repeats of the vertebrate thrombospondin (TSP)-1,-2,-3,-4 and TSP-5/also known as COMP (cartilage oligomeric matrix protein), and related proteins. These short aspartate-rich repeats are a continuous series of calcium binding sites that can be divided into two sequence motifs: N-type and C-type. N-type and C-type motifs are distinguished by their sequence length, calcium ion binding, and their interactions with water molecules. C-type motifs are higher affinity binding sites compared to N-type motifs.
Links
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Statistics
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PSSM-Id: 275365
Aligned: 31 rows
Threshold Bit Score: 54.9338
Created: 22-Dec-2011
Updated: 21-Oct-2014
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1: C-type Ca binding site_TSP3-short [ion binding site], 6 residue positions
Conserved feature residue pattern:[DEN] [DEN] [DEN] [DEN] [DEN] [NDE]Click to see conserved feature residue pattern help
Evidence:
  • Comment:C-type Ca binding site on a TSP3_short repeat
  • Structure:3FBY: C-type motif in a short TSP3 repeat of human COMP/TSP5 binds two Ca2+ ions
    - View structure with Cn3D
  • Comment:C-type motifs bind 2 Ca2+ ions; these Ca2+-binding sites are essentially "closed" in that they have limited accessibility to the solvent or other macromolecules.
  • Citation:PMID 2430973
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       # # #   #  #      #                                             
3FBY_A     129 RNTDEDKWGDACDNCRSQKNDDQKDTDQDGRGDAC------DDDIDGDRIRNqaDNCPRVPNSDQ 187  human
1YO8_A     277 RDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCd----nNEDIDDDGHQNnqDNCPYISNANQ 337  human
3FBY_A     188 KDSDGDGIGDACDNCPQKSNPDQADVDHDFVGDACd----sDQDQDGDGHQDsrDNCPTVPNSAQ 248  human
1304281A   822 RDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCd----nNQDIDEDGHQNnlDNCPYVPNANQ 882  human
1304281A   763 YDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDAC------AADIDGDGILNerDNCQYVYNVDQ 821  human
EKC18263  2094 TDSDGDGVGDECDNCPQTSNPTQTDSNYSGVGDSCd-----GQDKDGDGIPDfkDNCPEVPNAQQ 2153 Pacific oyster
NP_009043  587 TDRDEDGVGDACDSCPEMSNPTQTDADSDLVGDVCd----tNEDSDGDGHQDtkDNCPQLPNSSQ 647  human
ELU16244   234 TDSDSDGVGDACDNCANIANAPQTDANQNGFGDVCdstgatDVDRDGDGILNgfDNCLVIPNADQ 298  Capitella teleta
Q6YID6     216 ADGDGDGFGDLCDNCPQHTNPGQEDADEDLLGDACd----dNIDSDSDGVEDsvDNCPNVANGDQ 276  black tiger shrimp
ACY18534    87 ADSDGDGVGDACDNCVDAFNPDQANSSADDFGDAC------DADRDGVLDVE--DNCPTTANSDQ 143  Haliangium ochraceum

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