2AZE


Conserved Protein Domain Family
DP_DD
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cd14458: DP_DD 
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Dimerization domain of DP
DP functions as a binding partner for E2F transcription factors. DP and E2F form heterodimers and play important roles in regulating genes involved in DNA synthesis, cell cycle progression, proliferation and apoptosis. The transcriptional activity of E2F is inhibited by the retinoblastoma protein (Rb) which binds to the E2F-DP heterodimer, blocks the transactivation domain, and negatively regulates the G1-S transition. DP is distantly related to E2F. In humans, there are at least six closely related E2F and two DP family members, all containing a DNA binding domain, a coiled-coil (CC) region, and a marked-box domain. E2F1 to E2F5 also contain a C-terminal transactivation domain.
Links
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Statistics
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PSSM-Id: 271217
Aligned: 62 rows
Threshold Bit Score: 84.1612
Created: 22-Dec-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 52 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Comment:E2F proteins form heterodimers with one of two DP proteins; this enhances the Rb binding, DNA binding, and transactivation activities of E2Fs
  • Structure:2AZE: Human E2F1-DP1 heterodimer; contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #   #  ## ##  ## ##  ##  #  ##  #  ## ## ###  #               ############ #    
2AZE_A         3 FAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRHAEQqasrp-----pppnSVIHLPFIIVNTsKKTVI 77  human
ACO60994     273 KEDDMEALRAEKARAQASIEKKNAYLLELVEQYKSYQALLQRNAARAAagv---------vpSGIQLPFILVQTkPNATV 343 Micromonas sp. ...
Q1ZZK3       158 SCNSADRVKAERDAKIKEVEQKQLYLQDMVEQQKALKKLLERSAARQSngan-------tseTKLFLPFILVQAkPDATV 230 Chlamydomonas r...
Q5SCA9       172 TPRTAAPTWATSEAGIEEFEKKVNHLAELVEQHDAIIALVDRNREAMAksng-------apiTGIQLPFILIQTkADAEV 244 Ostreococcus tauri
XP_001420110 170 AGPRTSNRELASTESIDAFEQKTNYLAELVEQHDALVALVERNQKALAgdg--------pppTGIQLPFILIQTkSEAEI 241 Ostreococcus lu...
Q84VF4       179 RYEKIQKLEEVHKELITRIKNKKKLLQEIEKQFDDLQNITLRNQASQRpae---------svNGILLPFLLIKTsRKARV 249 Oryza sativa Ja...
EKX54369     267 LSKERSRLLQEIENKKKEVEDKNTLVRDLATQFVSLKRLLSRNELTEHepc---------hqKKIYLPFVIVNTdMDNSV 337 Guillardia thet...
EIE27202     278 PASTLERLKEQRVRLRAKLAQQHAYLKETSKQHAAYRNLIVRNLDRPAsalasiaaphgaapTALPLPFILIQVnPEASV 357 Coccomyxa sp. C...
EKX52206     240 NDETRDSTMSRITALEKSIRKKSREIEQKASHFISLKNIVKRNSEQGAaeta------eadkCKLQIPFVVAQTkDIHDV 313 Guillardia thet...
EJY77084     282 THEFIIKAKIEIEEAKNRLQQKTAHFLELAQQSIALKKLVARNYMMYHsrenq-----sapeKKIDIPFVVLKLqKNAQV 356 Oxytricha trifa...

Feature 1              ######### #  # #     ## # 
2AZE_A        78 DCSISNDKFEYLFNFDNT-FEIHDDIEVLKRM 108 human
ACO60994     344 EVEISEDQQIVHFDFNSTpFQIHDGNFVLAQM 375 Micromonas sp. RCC299
Q1ZZK3       231 EVKISDDMMDVQFDFYHSpFQIHDDSHVLKKM 262 Chlamydomonas reinhardtii
Q5SCA9       245 DVEISEDQRHVHLDFNQTpFQIHDGFHVLTKM 276 Ostreococcus tauri
XP_001420110 242 DVEISDDQRTVHFDFNRTpFQIHDGFHVLTKM 273 Ostreococcus lucimarinus CCE9901
Q84VF4       250 EIEISEDSKFARFDFNGApFTMHDDVSILEAI 281 Oryza sativa Japonica Group
EKX54369     338 VCEISQDEKFAEINCTKP-FKLYDDRGTLSKM 368 Guillardia theta CCMP2712
EIE27202     358 EIQIADDNRQAMFDFAGTcFRIMGDDEVLYEM 389 Coccomyxa sp. C-169
EKX52206     314 ELEIHTDRKRASLYFSNK-FELHDDKSILDFM 344 Guillardia theta CCMP2712
EJY77084     357 ELQQKDDQTQLILQTDRE-LEMFNENHILQKL 387 Oxytricha trifallax

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