2AZE


Conserved Protein Domain Family
E2F_DD
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cd14660: E2F_DD 
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Dimerization domain of E2F transcription factors
E2F transcription factors are involved in the regulation of DNA synthesis, cell cycle progression, proliferation and apoptosis. It associates with the retinoblastoma (Rb) protein, negatively regulating the G1-S transition until cyclin-dependent kinases phosphorylate Rb, which causes E2F release. E2F forms heterodimers with DP, a distantly related protein. Heterodimerization enhances the Rb binding, DNA binding, and transactivation activities of E2Fs. In humans, there are at least six closely related E2F and two DP family members, all containing a DNA-binding domain, a coiled-coil (CC) region, and a marked-box domain. E2F1 to E2F5 also contain a C-terminal transactivation domain.
Links
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Statistics
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PSSM-Id: 271137
Aligned: 96 rows
Threshold Bit Score: 93.3512
Created: 2-Mar-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 52 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Comment:E2F proteins form heterodimers with one of two DP proteins
  • Structure:2AZE: Human E2F1-DP1 heterodimer; contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ##  ## ##  ## ##  ## ## ### ##  #          ######  ##  #   #########           
2AZE_B         6 GRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDtd---sqRLAYVTCQDLRSIadpAEQMVMVIKAPPETQLQAVD 82  human
EFN84044      86 DKLIDLKDEIRKLEDHEHLLDTHMQWIQQSIKNIENDvi---nrKYAYITYEDVKENf--QEQFVLGIQAPSDTELTVPN 160 Harpegnathos sa...
XP_003970107  89 RRMTDLRSELRDLEQKETFLDLQKFWIEQSIRNTAEDcs---kyPLIYVNHEDVCNCf--SGRTVLAVRAPTGTKLEVPI 163 torafugu
XP_003384656  94 MKVQGLKEKKQKMEESESKLDKQCAKIKQCLKNIVEDpg---snSLAFVTYEDIRSIpcfKKATMLAIQAPSDTLITVDT 170 Amphimedon quee...
XP_004067251  94 RILMKLKAEVSHLECREHFLDQQKLCIEQNIKEITENd-----rDSVYVTHDDICNSf--CGRTVLTVRAPQDTTLDVPI 166 Japanese medaka
XP_004079571  92 EQVGLLKAQISQLEALEEELDQQKVCLEESIQALSHVcfpqrrsTYTFVTHEDICRAf--EGETLLAIVAPAETQLEVPV 169 Japanese medaka
XP_003744349  87 QRRLEFSAQVEELKKIEDALDDHLKQAKQSVVNVKEDis---nrGKAYISYRDLWDVm--EAGSILTIRGPADTTLKVFD 161 western predato...
XP_002403900  50 DRLSALQKELEELEAAEQKLDEHRAWAQQSLLNITEDaa---nvAQAYLPIKALHACfegTASTLLSLRGPPGTSIRVPD 126 black-legged tick
CAZ36532     102 ARLDELQAEVEYLENLEKKVDEHRGKVLQSLKNVQEDld---nlQYAYVTHQDLINIf--QDRTMLIIRAPPGTKLEAPV 176 Schistosoma man...
ESO06914      92 SRINSKKDQISKMLSYEEDLDRLKSCIEQSLLNVTDEhe---sqKRNYLKDDDICKCl--KDLTILTIKAPNGTQLVAAV 166 Helobdella robusta

Feature 1                          ######## #### #     #
2AZE_B        83 SSE---------------NFQISLKSKQGPIDVFLCPEE 106 human
EFN84044     161 ISKdna----------vlNYNMHLKSNSGEIKVYTIQPE 189 Harpegnathos saltator
XP_003970107 164 PKVvhr---------cptKYQIYLKSINGPIDVLLLSKR 193 torafugu
XP_003384656 171 PTThp-----------dgLYCMQIKSKSGPVSVLVIGGN 198 Amphimedon queenslandica
XP_004067251 167 PKAvpn---------cpaKYQIYLKSLKGPIDVILFNKC 196 Japanese medaka
XP_004079571 170 PDTggg---------gqkSYQVNLRSRRAPIRVLLIDRD 199 Japanese medaka
XP_003744349 162 PSShree--------etnSFYVHCKSDHGPVEVHLIDKE 192 western predatory mite
XP_002403900 127 LRQdv-----------ekCFWLLAKSDQGPVDVLLMDKR 154 black-legged tick
CAZ36532     177 PENpmdqqpvqtifslkrSYKVHVKSFTTPIHVLLVNQE 215 Schistosoma mansoni
ESO06914     167 PTDnnq----------qdKYKMTIKSVNGPINVLLLNKD 195 Helobdella robusta

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