2J5W


Conserved Protein Domain Family
CuRO_3_ceruloplasmin
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cd04224: CuRO_3_ceruloplasmin 
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The third cupredoxin domain of Ceruloplasmin
Ceruloplasmin is a multicopper oxidase essential for normal iron homeostasis and copper transport in blood. It also functions in amine oxidation and as an antioxidant preventing free radicals in serum. The protein has 6 cupredoxin domains with six copper centers; three mononuclear sites in domain 2, 4 and 6 and three in the form of trinuclear clusters at the interface of domains 1 and 6. Ceruloplasmin exhibits internal sequence homology that appears to have evolved from the triplication of a sequence unit composed of two tandem cupredoxin domains. This model represents the third cupredoxin domain of ceruloplasmin.
Links
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Statistics
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PSSM-Id: 259886
Aligned: 7 rows
Threshold Bit Score: 352.546
Created: 4-Jun-2012
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Domain 4Domain 2
Conserved site includes 46 residues -Click on image for an interactive view with Cn3D
Feature 1:Domain 4 interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                      ## ## # ##                   ## ######  #####                    ##
2J5W_A        369 KHVRHYYIAAEEIIWNYAPSGIDiftkenlt---apgsdsavFFEQGTTRIGGSYKKLVYREYTDASFTNRKergpEEEH 445  human
CAG00485      302 PVVRNYYIAVEKVLWDYAPSGKDltnhtnhtlltaegsasetFFGRNNKRIGGQYNKVMYKEYTDDSFTTEKpqtkEAEH 381  Tetraodon nig...
Q9BQS7        377 GKVRQYFIEAHEIQWDYGPMGHDgstgknlr---epgsisdkFFQKSSSRIGGTYWKVRYEAFQDETFQEKMhl-eEDRH 452  human
NP_001098580  376 GTERHFYIAAEEMMWDYAPSGMNymenvtlt---kpesdsepFFSKEGGKLGGKYMKARYVQYTDQTFTSKThivgSDEH 452  zebrafish
Q6MZM0        377 GQQRRYFIAAEKILWDYAPQGYNkfsglpln---asgsdsdlYFTQGDNRIGGKYWKVRYTEFVDATFTKRKrlsaEEAH 453  human
XP_001235149  370 TKIRQYFIAAEEIIWNYGPSALNhftgqeli----adsesyvFFERSETRIGGSYKKAIYKEYTDGTFTAHKkrlpEEEH 445  chicken
XP_002937375  370 GRERRYFIAAEEAMWNYAPTDTNqftgqkid---hpdtesaiFFQRNEVRIGGTYTKAVYVEYTDATFTTRKqrskDEEH 446  western clawe...

Feature 1         ####  #                  #      #                                               
2J5W_A        446 LGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKnnegtyyspnynpqsrsvppsaSHVAPTETFTYEWTVPKEV 525  human
CAG00485      382 LGLLGPVLRAEEGDTIKVTLRNKADRAFGIQPHGLFYESctsss------------klfttTYISPGKNFTYVWQVKDGP 449  Tetraodon nig...
Q9BQS7        453 LGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKdyegtvyn-------dgssypgLVAKPFEKVTYRWTVPPHA 525  human
NP_001098580  453 LGILGPVIRAETGDVIIVTFLNKARRNYSIQPHGLHYEKvyegamy---------vdgsqkAPVGPGQKFTYRWRVIEGP 523  zebrafish
Q6MZM0        454 LGILGPVIKAEVGDTLLVTFANKADKVYSILPHGVIYDKasdaapnl-------dgfvkpgAHVKPGETFTYKWTVPESV 526  human
XP_001235149  446 LGLLGPVIKAEVGESIRVTFRNNASRPFSIQPHGVSYHKsnegalyrt----asrdtespaSHVSPGTTFTYEWTVPEDV 521  chicken
XP_002937375  447 LGILGPVMIAQVGDSMKVTFKNKASRPYSIQAHGVSYSKnmegasyrtg--nltnddpspgSHVAPGDTFTYEWEVSSAV 524  western clawe...

Feature 1                 ### # #     ######  # # #           ###
2J5W_A        526 GPTnaDPVCLAKMYYSAVDPTKDIFTGLIGPMKICKKGSLHANGRQK 572  human
CAG00485      450 SSS--DPPCIPYLYFSGAQPVADTYSGLMGPLLVCKKGSLAENGRQK 494  Tetraodon nigroviridis
Q9BQS7        526 GPTaqDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQK 572  human
NP_001098580  524 SAD--DPPCISYLYYSAVDPVRDTNSGLFGPIQVCKKGVLDRSGHQV 568  zebrafish
Q6MZM0        527 SPTagDPPCLTYLYFSAVDPIKDTSSGLVGPLLVCKKGVLNADGTQK 573  human
XP_001235149  522 GPTdqDPDCLTWLYYSAVNSVRDTSSGLVGPLMVCRKGALLPSAKQK 568  chicken
XP_002937375  525 GSTnqNLNCLVWLYFSSVDAIKDTNSGLVGPLLICKSIDANNHQRGI 571  western clawed frog

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