Conserved Protein Domain Family
TIMELESS_C

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pfam05029: TIMELESS_C (this model, PSSM-Id:252956 is obsolete and has been replaced by 461529)
Timeless protein C terminal region
The timeless (tim) gene is essential for circadian function in Drosophila. Putative homologs of Drosophila tim have been identified in both mice and humans (mTim and hTIM, respectively). Mammalian TIM is not the true orthologue of Drosophila TIM, but is the likely orthologue of a fly gene, timeout (also called tim-2). mTim has been shown to be essential for embryonic development, but does not have substantiated circadian function. Some family members contain a SANT domain in this region.
Statistics
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PSSM-Id: 252956
Aligned: 5 rows
Threshold Bit Score: 333.233
Created: 20-Mar-2019
Updated: 18-Jul-2019
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9NAX2  736 ILHRIAYGCKCAGMLFQAKLFRIFQQVFSVERDVHQ-----EELRRLA---IFVVRKFVEVAPTNPKIYAELLFYKGIRE 807  fruit fly
Q9UNS1  728 MLHRLAHDLKMEALLFQLSVFCLFNRLLSDPAAGAY-----KELVTFA---KYILGKFFALAAVNQKAFVELLFWKNTAV 799  human
Q9Z2Y1  725 MLHRLAHDLGMEALLFQLSLFCLFNQLLSDPAAAAY-----KELVtf---aKYILGKFFALAAVNQKAFVELLFWKNTSV 796  Norway rat
Q5AXH3  643 YFYRIAFKQEMTVLLFRVDILNLFYRIIKGPGGMDSskpiyKEWEELV---RQLIRRLIKKLEQRPALITELLFSKINST 719  Aspergillus nidulan...
Q9FLX0  688 ILRRITEDLELAPMLYQLSLLITFHKILDEQKVCPC-----KDYENIVtflTDLVRNMLKKMKSQPLLFVEILFSKTRKE 762  thale cress
Q9NAX2  808 ANELESGYCDAY-EAGTKG------AWTEEQESELRFLFEENQRNp-eTDKDVIDWILDNLVDKTRNRRTVLKKLKE--- 876  fruit fly
Q9UNS1  800 VREMTEGYGSLDdRSSSRRa----pTWSPEEEAHLRELYLANKDV---EGQDVVEAILAHLNTVPRTRKQIIHHLVQ--- 869  human
Q9Z2Y1  797 VREMTQGYGSLDsGSCSHRa----pVWSSEEEAQLQELYLAHKDV---EGQDVVETILAHLKAVPRTRKQVIHHLVR--- 866  Norway rat
Q5AXH3  720 AFYLEYGFEKQTv-TTSKRapaeleVDPKAASTPEEKLSIVVAALvkdEQSALVKWISEVLGSAADEREAWELNSHDvdl 798  Aspergillus nidulan...
Q9FLX0  763 CHYINAEYMLHElGHLRKQmgnqekFSGTEEFGTSSD----------------KGWAHRSLADALGDDEADVVISYD--- 823  thale cress
Q9NAX2  877 LGLLFKAPTKrstk-------saqSGKN----VWQ------------------------PEEDD-ELRSLY-------DQ 913  fruit fly
Q9UNS1  870 MGLADSVKDF--------------QRKGthivLWT------------------------GDQEL-ELQRLF-------EE 903  human
Q9Z2Y1  867 MGLADSVKDF--------------QRKGtqivLWT------------------------EDQEL-ELQRLF-------EE 900  Norway rat
Q5AXH3  799 AGPRDTQNPIitvksqdnsfkramFQNAklrlLMTllkfdrlgqenvegiswiipselkSDELReSKAVIDkallignTD 878  Aspergillus nidulan...
Q9FLX0  824 QGFQNEDDDMvedk-------sagPSKRkrrlVLD------------------------GDMDI-KIKDLYdrykddkNC 871  thale cress
Q9NAX2  914 HRIEPDCLERL-------------VNEFAERRSKQQIIKR---MLQIHLIADKSEILpaKKGRGKDKPK-K-DVEMEGEG 975  fruit fly
Q9UNS1  904 FRDSDDVLGHI-------------MKNITAKRSRARIVDK---LLALGLVAERRELY--KKRQKKLASSiLpNGAESLKD 965  human
Q9Z2Y1  901 FQDSDDVLGHI-------------MKNITAKRSRARVVDK---LLALGLVSERRQLH--KKRRKKLAPScMqNGEESQRD 962  Norway rat
Q5AXH3  879 ERDPNDLLRKKysheprdgfsgqnLDVNFGSDSEGEDVIPdgpLFPANPRSKAHALNelKQKRKKRKDK----------- 947  Aspergillus nidulan...
Q9FLX0  872 SRLIAENLVP------------------DGGISAAQVTNK---LKQLGLETRKRLRRggTDHLDATSLAqP-S------- 922  thale cress
Q9NAX2  976 defDFAEEPMFEDQgykKPKSKPKKVQKRQM-VRTPLDVGTIRA--LIGQVDSEKYQSAIEWLQECLQDASEDTEEAvED 1052 fruit fly
Q9UNS1  966 ---FCQEDLEEEEN---LPEEDSEEEEEGGSeAEQVQGSLVLSNenLGQSLHQEGFSIPLLWLQNCLIRAADDREED-GC 1038 human
Q9Z2Y1  963 ---AWQEDPEEEEEkegLPESEGEENEEDLL-AGQVQGSSSLSAenLRQSLCQDGLSAPLLWLQSSLIRAADDREED-GC 1037 Norway rat
Q5AXH3  948 ----------------------------------GEEEPVDEETleERRQARLENTRWRLAKIKSDLYVHASDEESDaEA 993  Aspergillus nidulan...
Q9FLX0  923 ------------------------NTRKRVS-SFSKEQETLIKE--LYKKFKDEK------------------------- 950  thale cress
Q9NAX2 1053 DDGVPLLPLMENQKNAMEDGDFQKVLVALGMQPPI---SGMEAYWRIPIYLNSADLILRSKILAGEEvdAEPED--EAAD 1127 fruit fly
Q9UNS1 1039 SQAVPLVPLTEENEEAMENEQFQQLLRKLGVRPPA---SGQETFWRIPAKLSPTQLRRAAASLSQPE--EEQKLqpELQP 1113 human
Q9Z2Y1 1038 SQAIPLVPLTEENEEAMENKQFQHLLRKLGIRAPC---SGQETFWRIPAKLSSTQLRRVAASLSEREnkEEREEepEPNP 1114 Norway rat
Q5AXH3  994 DQ------EFFRLEEERRNEQSERIKKAL-----LlgrTEDAGN------------------------------------ 1026 Aspergillus nidulan...
Q9FLX0  951 -RCCYLIASELGSENTYTTAQVSRKLKQLGLRLPRgkkS-EAGM--------------------------------MLKD 996  thale cress
Q9NAX2 1128 DEDGEE-AEES---DEEEDFLEK--HSRQRKENIATQQQR-KLDslmfnqsddETEQRAPPKAKDKpkasekkakrkvkg 1200 fruit fly
Q9UNS1 1114 KVPGEQgSDEEhckEHRAQALRAllLAHKKKAGLASPEEEdAVG---------KEPLKAAPKKRQL-------------- 1170 human
Q9Z2Y1 1115 GVPGEQs-pSE---EHQVRAPRAllSARKRKAGLVFPKEE-ATG---------EEEWKSVPKKQQL-------------- 1166 Norway rat
Q5AXH3 1027 -------------------------KARQRKRGKRSNEPniageeets-------------------------------- 1049 Aspergillus nidulan...
Q9FLX0  997 DHDDSS-ADES---EDETLLAFK--NRKSRKnqknkqqtg---------------------------------------- 1030 thale cress
Q9NAX2 1201 kakeskdcnddgtdkaelekpntddlfnqlrakratkiklsdmalnesTNAAQEADDdafNFnsedyrarlleledeeqn 1280 fruit fly
Q9UNS1 1171 ------------------------------------------------LDSDEEQEE---DE------------------ 1181 human
Q9Z2Y1 1167 ------------------------------------------------LDSDEEDTD---DE------------------ 1177 Norway rat
Q5AXH3 1050 ---------------------------------------gkrrrhsggTNVELEEDDilmDDmempsrassgeyssndad 1090 Aspergillus nidulan...
Q9FLX0 1031 ---------------------------------------sineitpggSEDNTERNEtslHEptageeedndqsyitres 1071 thale cress
Q9NAX2 1281 skdade--nggdkenitnkslqrarrvnvidsDSDNDDDGALPADKTNKRPrsdddgdsghmdanaeedsdeeanflark 1358 fruit fly
Q9UNS1 1182 --------------------------------GRNRAPELGAPGIQKKKRY----------------------------- 1200 human
Q9Z2Y1 1178 --------------------------------RGGQAAVSGTLRIHKEKRF----------------------------- 1196 Norway rat
Q5AXH3 1091 aidksmaaaedelyfdddlafgrdrdkdetsvDRDGADA-SSPRKHNDGSEsaeediplap------------------- 1150 Aspergillus nidulan...
Q9FLX0 1072 rqse------tdvhisdngpstslpedpnlssDNELEDD-ELADWGDDSAAggasltqsp-------------------- 1124 thale cress
Q9NAX2 1359 kpakvdgepakrrrlaIIDdDDE 1381 fruit fly
Q9UNS1 1201 ----------------QIE-DDE 1206 human
Q9Z2Y1 1197 ----------------LVEdEDE 1203 Norway rat
Q5AXH3 1151 ------pnrrrlragfVVEsDSE 1167 Aspergillus nidulans FGSC A4
Q9FLX0 1125 --------lsrrklkmVLDkDDE 1139 thale cress
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