Conserved Protein Domain Family
SPRY2_RyR
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cd12878: SPRY2_RyR 
SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1
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Statistics
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PSSM-Id: 240458
Aligned: 14 rows
Threshold Bit Score: 232.191
Created: 15-May-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q92736    1086 RIFRAEKTYAVkaGRWYFEFETVTAGdMRVGWSRPGCqpdqELGSDERAFAFDGFkaQRWHQGNEH-YGRSWQAGDVVGC 1164 human
CCD59582  1051 RTYRGQATRAVtrGKWYYEAEILTSGfIRIGWAKKSAppdlIIGSSSSSYAFAAHqaRKWNRNGSV-YGTICRPGDVIGC 1129 Schistosoma mansoni
EEC03458   681 RTYRAERTYAVtdGKWYFEFEVLTLGvMKVGWAGPNFlpscELGGDDNSWAFDGFkaAKNHAGGSEvYGKQWQIGDVIGC 760  black-legged tick
EFX89429  1078 RTYRAEKTYAVssGKWYFEFEVLTSGpMRVGWARADAkagyQLGQDDCSWAFDGWreEKFYVGSGEsFGKHWSAGDCVGA 1157 common water flea
NP_996757 1071 RFYRVEQSYAVksGKWYFEFEAVTGGdMRVGWARPGCrpdiELGADDQAFVFEGSkgQRWHQGSGF-FGRSWQPGDVVGC 1149 chicken
Q24498    1079 RTYRVERNYAVtsGKWYFEFEVLTSGpMRVGWARADCypgaMLGSEDTSWAFDGHnvTKMHAGSIEhFGVRYEAGDVIGC 1158 fruit fly
BAB84714  1088 RTFRAEKSYAVksGRWYFEFEAMTTGyMRVGWGRPTIaarsEVGTDGCSFAFDGFlaRKWHQGSET-FGKTWGEMDVIGC 1166 Hemicentrotus pu...
EDV29875  1168 RTFRVEKMYAVrrGKWYYEFHVNSPGmMRVGWCSEFFeagkEVGGSSNSYSYDGFlaRKWNHGSES-FGKTWNKGDIVGC 1246 Trichoplax adhae...
P91905    1078 RTYRAEATYAVcgGKWYFEFEILTAGyMKIGWMDIGStpeiQLGADDRSYAFDGYlgRKWHQGAET-YGKEWKIGDVVGC 1156 Caenorhabditis e...
EEN53162   815 RTYRGEKTYAVkkGKWYFEFEIVDTGnMRVGWCSPLTrsdeDLGSDNLSYAFDGFygLKWHGHHES-FGRTWRPGDVVGC 893  Florida lancelet

Q92736    1165 MVDMNehTMMFTLNGEILLDDSGseLAFKDFdv--gdGFIPVCSLGvAQVGRMNFG 1218 human
CCD59582  1130 MMDLVdkTISFSLNGELMMDPLGleIAFKHIkv--deGYVPAFSLGsGQQVKINYG 1183 Schistosoma mansoni
EEC03458   761 MLDLHdrTISFSLNGELLLDSLGgeTAFSDIpcgegaSYVPACTFGiGQKARLVFG 816  black-legged tick
EFX89429  1158 FLDLVdrTISFSLNGELLMDSMGseTAFTDIqg---eEFIPAFTLGvGQRARLVFG 1210 common water flea
NP_996757 1150 MINLDdkSIIFTLNGELLITSKGseLAFADFgi--esGFVPICSLGlSQIGRMNLG 1203 chicken
Q24498    1159 FIDVKeqTISFSLNGELLMDALGgeTTFADVtae-gvGFVPACTLGvGQKARLIYG 1213 fruit fly
BAB84714  1167 MLNLVdnTISFTMNGEYLCDSVGseMAFHDIei--geGFVPVCMLAaGEKAHLHFG 1220 Hemicentrotus pulcherrimus
EDV29875  1247 LLDLDtgKISFTLNGELLQDGMSs-YAFEDIdv--tvGYLPACSLAvGQSGRINFG 1299 Trichoplax adhaerens
P91905    1157 FLDLNdrTISFSLNGELLLDPSGseMAFDNVvc--gdGLVPAMTLGsGQRGRLNFG 1210 Caenorhabditis elegans
EEN53162   894 LLDLNdrHISFTYNGELMVDKNGqeVAFKDIei--geGYVPACSLAkGEKARLNLG 947  Florida lancelet
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