Conserved Protein Domain Family
Commd3
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cd04751: Commd3 
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.
Links
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Statistics
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PSSM-Id: 240099
Aligned: 13 rows
Threshold Bit Score: 87.7892
Created: 12-Feb-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001008734  97 DIFYTSFQKNKQNVESLLSSIDi--cPPHITDAAWRLEYCIKN----SHVHKVNQPSy---lISLNTESggc---sskIK 164 zebrafish
XP_788467     96 DAFLKHFQEKKQEIRSMLSNIGh--tPPHIVDVDWRLDFYLKN----KHIDKINQPTy---lINLKTEQghrg--akdIQ 164 purple urchin
CAF97970      98 EIITSAYQKHKKDLERLLTSIGt--sPPQVHDVSWRLQQHVKN----AHLDKVNQPFf---dISLKTENrgv---pedIN 165 Tetraodon nigro...
AAH87507      99 ELFWTEYQKNKESLETLLGSIGi--sPPHITDVSWRLQYQIKS----NQLYRHNRPDy---lINLTVESsdan-qkpeIS 168 African clawed ...
CAI15953      51 ELFCTEYQNNKNSLEILLGSIGr--sLPHITDVSWRLEYQIKT----NQLHRMYRPAy---lVTLSVQNtdsp-sypeIS 120 human
XP_638867     97 IDFISNYFKEYRVAIRKHLSVTnf-hFPHIIDVNWRLDLFMKS----NAVEKLNTPVy---lINLTTEQeenv--kgkVQ 166 Dictyostelium d...
XP_001016572  81 SQFIEFISDKDNERSNFFDSSIn---FNKLVDVDWKQEYVLSTky-iKHLNKDNYHIs---lSTLNSENqi-----spIN 148 Tetrahymena the...
NP_572536    112 DELSRVYEDSRKDLILRQLQIGh--sFPHITDIQWRIVCDVKSstsdCSTGAACFHInlgnfRQSSGERvt------iVE 183 fruit fly
XP_653799     84 SVLAEIYDLHKEVLRNILKETTt--iLTKIIGVSWKLDFFVRPe--hKEISPVFLVTlk-tkEQNNEGK---------LD 149 Entamoeba histo...
XP_001322177  86 NYIADQYSAKVELIRAKLATISa--gYPKVVGCNWRLDYAVSN----SETGSVLKPLf---fVQLDLEGgs------qLN 150 Trichomonas vag...
CAK76391     105 FTQFKQFVNDPDNAIIAANFESki-gFNYLVDVDWQQEIVVSS----KYANKVYQEIy---kIQLHTKStdnk--dkdIV 174 Paramecium tetr...
EAT37981      79 EKIVAKYSLFRDTYTPKNAEYGi--aLPHVTDANWTLRSDLSSs--sHSVSAGNLSFs----IELESFNresnekepaIR 150 yellow fever mo...
CAL57841      90 EILAKSYGEIKRGLEERMKRHAmsspILKLSAHACRADYVVSTsa-nGDAREPGFHLs----WVLSDGRgeg----erVN 160 Ostreococcus tauri

NP_001008734 165 FNCTMEQLQDLVGKMKDAAKSVERATQ 191 zebrafish
XP_788467    165 FSCSLEQLQDLVGKLKDATKSLEKAAQ 191 purple urchin
CAF97970     166 FTCSMEQLQDLLGKLKDAAKSVERASQ 192 Tetraodon nigroviridis
AAH87507     169 FDCSMEQLQDLLGKLRDAAKSLERTTQ 195 African clawed frog
CAI15953     121 FSCSMEQLQDLVGKLKDASKSLERATQ 147 human
XP_638867    167 FAATLDQLQDLVFKLRDAQKQIERSSI 193 Dictyostelium discoideum AX4
XP_001016572 149 FKCSIEQLTELVHKLSSAVRNIEQATD 175 Tetrahymena thermophila SB210
NP_572536    184 FVCNAEELQSLINRLKEIERHCQQMAV 210 fruit fly
XP_653799    150 FVCTHEEMEDLITKLKDAQQQIERSAS 176 Entamoeba histolytica HM-1:IMSS
XP_001322177 151 FTCTEEEMTSLVSSLKEAAAEAARTKQ 177 Trichomonas vaginalis G3
CAK76391     175 FKCTLPQLIEINNQLGIMVKNIESSSD 201 Paramecium tetraurelia
EAT37981     151 FTCTPEELQLFINKLKDIELNCDKLTK 177 yellow fever mosquito
CAL57841     161 FECDAEEMAHLVETLREACRASEMIAA 187 Ostreococcus tauri
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