Conserved Protein Domain Family
ZnMc_BMP1_TLD
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cd04281: ZnMc_BMP1_TLD 
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, and proteins involved in the mineralization of the extracellular matrix. The drosophila protein tolloid and its Xenopus homologue xolloid cleave and inactivate Sog and chordin, respectively, which are inhibitors of Dpp (the Drosophila decapentaplegic gene product) and its homologue BMP4, involved in dorso-ventral patterning.
Links
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Statistics
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PSSM-Id: 239808
Aligned: 10 rows
Threshold Bit Score: 386.797
Created: 22-Jun-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site
Feature 1:active site [active site]
Evidence:
  • Comment:consensus motif: HEXXHXUGUXH U= bulky hydrophobic
  • Comment:coordinates zinc, contains catalytic Glu
  • Citation:PMID 8253063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                      
P25723     137 AVTVRKERTWDYGVIPYEIDTifsGAHKALFKQAMRHWENfTCIKFVERDpn--lhANYIYFTVKnCGCCSFLGKNGNGR 214  fruit fly
1345615    101 AVTARPERRWTDAVIPYEIDGnftGSQRAMFKQAMRHWENyTCITFVERNpansehDNHIVFTYQaCGCCSFVGRKGDGA 180  Strongylocentrot...
O57460     157 AATSRAEKIWPGGVIPYVIGGnftGSQRAMLKQAMRHWEKqTCVTFIEKTd----eESYIVFTYRpCGCCSYVGRRGNGP 232  zebrafish
CAD66417    82 AATGDLSRLWQDGVIPYQIQSnftAHQKAIFVSAMRHWENyTCITFVERTt----ePDFIVFTQRpCGCCSFVGRELRGA 157  Pacific oyster
P98070      84 ASTSRPERVWPDGVIPYVISGnfsGSQRAIFRQAMRHWEKhTCVTFLERTd----eDSYIVFTYRpCGCCSYVGRRGGGP 159  African clawed frog
Q20176      48 AATAKKERIWPEGIIPFVIASnfsGEHQHLFLRAMRHWENfTCVSFVPRQph---hKHYITFTVDkCGCCSYVGRRGEGP 124  nematode
BAE06735   345 AATARQERKWPHGVIPYTISAnftGSQRAMFKQAMRHWEGqTCLTFIERTn----eDNYIRFTYRpCGCCSYVGRKGTGP 420  Ciona intestinalis
Q9Y6L7     150 ATTSRTERIWPGGVIPYVIGGnftGSQRAIFKQAMRHWEKhTCVTFIERTd----eESFIVFSYRtCGCCSYVGRRGGGP 225  human
Q9DER7     144 AATSRTERIWPGGVIPYVIGGnftGTQRAMFKQAMRHWEKyTCVTFIERSd----eESYIVFTYRpCGCCSYVGRRGNGP 219  chicken
ABC88377    31 AATAFVGRLWPGGVIPFEIADeytGEQKATILQAMRHWENfTCLSFIEHTe----eEDFIYFHKGrCGCCSYVGRKGNGR 106  starlet sea anemone

Feature 1                      ##  #     #                                                     
P25723     215 QPISIGRNCEKFGIIIHELGHTIGFHHEHARGDRDKHIVINKGNIMRGQEYNFDVLSPEEvdLPLLPYDLNSIMHYAKNS 294  fruit fly
1345615    181 QAVSVGKNCDKFGVVVHELGHVVGFWHEHTRPDRNEFVGIVHQNIVPGQEYNFRVLDAAEvdSLGETYDFASIMHYARNT 260  Strongylocentrot...
O57460     233 QAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRDNIQPGQEYNFIKMEPGDvnSLGEPYDFDSIMHYARNT 312  zebrafish
CAD66417   158 QAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNYIQILSENIKENHDNNFAKMTLTEinSLGEEYDFSSIMHYARNT 237  Pacific oyster
P98070     160 QAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVSIIRENIQPGQEYNFLKMEPEEveSLGETYDFDSIMHYARNT 239  African clawed frog
Q20176     125 QAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDMYVDIFYKSIQTGQDYNFEKSKPEEvdSLGEPYDFSSIMHYARDT 204  nematode
BAE06735   421 QAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHIEIIYKNIQAGQEYNFEQMDSSEinSLGEKYDYYSIMHYARNT 500  Ciona intestinalis
Q9Y6L7     226 QAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEvsSLGETYDFDSIMHYARNT 305  human
Q9DER7     220 QAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRENIQPGQEYNFLKMEPGEvnSLGEPYDFDSIMHYARNT 299  chicken
ABC88377   107 QGISIGKNCDKFGIIVHEIGHLVGFWHEHTRPDRDQFVEIIRENIKKGEGHNFQKLTKAEidSRGEEYDYKSIMHYGKNT 186  starlet sea anemone

Feature 1                                                   
P25723     295 FSKSPYLDTITPIGIpp-gTHLELGQRKRLSRGDIVQANLLYKCA 338  fruit fly
1345615    261 FSRGIWLDTILPRKDpesgIRPEIGQRKHLSEGDIIQANLLYKCP 305  Strongylocentrotus purpuratus
O57460     313 FSRGMFLDTILPSRDen-gVRPAIGQRTRLSKGDISQAKKLYRCP 356  zebrafish
CAD66417   238 FSKSSDLDTLVPKTLt--aDIPEIGQRQRLSVGDIIQTNKLYKCP 280  Pacific oyster
P98070     240 FSRGIFLDTILPKYDvn-gVRPPIGQRTRLSSGDVAQARKLYKCP 283  African clawed frog
Q20176     205 FSRGAFYDTILPKPNs--gFRLEIGQRVQLSEGDIRQTKKLYKCA 247  nematode
BAE06735   501 FSKGMFLDTIRPMVDqetgMRPSIGQRTQLSEGDVIQANKLYSCP 545  Ciona intestinalis
Q9Y6L7     306 FSRGVFLDTILPRQDdn-gVRPTIGQRVRLSQGDIAQARKLYKCP 349  human
Q9DER7     300 FSRGMFLDTILPSRDdn-gIRPAIGQRTRLSKGDIAQARKLYRCP 343  chicken
ABC88377   187 FATSLNHVTILPKRSg--gMVPAIGQREHLSLGDIRQTIKMYRCP 229  starlet sea anemone

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