Conserved Protein Domain Family
alpha_CARP_X_XI_like
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cd03121: alpha_CARP_X_XI_like 
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.
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Statistics
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PSSM-Id: 239395
Aligned: 9 rows
Threshold Bit Score: 359.034
Created: 1-Nov-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAH68462   46 VPSFWGLVNSAWNLCSVGKRQSPVNIETSHMIFDPf----------------------------------------LTPL 85  human
XP_415644  46 VPSFWGLVNSAWNLCSVGKRQSPVNIETSHMIFDPf----------------------------------------LTPL 85  chicken
AAI07834   46 VPSFWGLVNSAWNLCSVGKRQSPVNIETSHMIFDPf----------------------------------------LTPL 85  zebrafish
AAF46521   37 GPAFWGLINPEWSLCNKGRRQSPVNLEPQRLLFDPn----------------------------------------LRPM 76  fruit fly
AAF46274   34 GPSFWGLINPQWNMCNKGRRQSPIDVVPDKLLFDPy----------------------------------------LRPL 73  fruit fly
AAA20616   39 GPHFWGLVEKDWWMCKKGRLQSPIDIQPDRLLFDAsvkpvsyaelnffliiyltislklmryiftcahlfacnkklGTWN 118 nematode
AAD08802    1 GPPFWGLVNAAWSLCAVGKRQSPVDVELKRVLYDPf----------------------------------------LPPL 40  human
NP_495567  16 GPDFWGLLHGDWRMCTAGQMQSPVNIDPSQLLYDPh----------------------------------------LMPI 55  nematode
XP_784796  38 CPAFWGRMYSAWFLCSKGQRQSPIDLRAESLVYDPn----------------------------------------LPQL 77  purple urchin

AAH68462   86 RINTgg--------------------rKVSGTMYNTGRHVSLRLDke---------hlVNISGGPMt-YSHRLEEIRLHF 135 human
XP_415644  86 RINTgg--------------------rKVSGTMYNTGRHVSLRLDke---------hlVNISGGPMt-YSHRLEEIRLHF 135 chicken
AAI07834   86 RLNTgg--------------------rKVGGTMYNTGRHVSLRLDke---------hlVNISGGPMt-YSHRLEEIRLHF 135 zebrafish
AAF46521   77 HIDKh----------------------RISGLITNTGHSVIFTAGndtvanydgmqtpVNISGGPLs-YRYRFHEIHMHY 133 fruit fly
AAF46274   74 HIDKh----------------------KVSGTLHNTGQSLVFRVDkdt-------kqhVNISGGPLa-YRYQFEEIYIHY 123 fruit fly
AAA20616  119 RIFGaniakfrawvvyiiifhaqvpqlQVVSEFVNTGQMVRVRIGyssk------kpsVNITSGPLygYRYRVQRIDFHM 192 nematode
AAD08802   41 RLSTgg--------------------eKLRGTLYNTGRHVSFLPApr---------pvVNVSGGPLl-YSHRLSELRLLF 90  human
NP_495567  56 NIEGn----------------------IVEAVFENTGQLPVVTVKdlpn------rptINITGGPTmpYRYKLHQISVHF 107 nematode
XP_784796  78 EIDSp---------------------aETNGIVNNTGRGISFFPDpa---------nvTYISRGPLs-YRYRLVEIRLHF 126 purple urchin

AAH68462  136 GSEDs--qGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIKVSDSSNPFLNRMLNRDti-------- 205 human
XP_415644 136 GSEDs--qGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLVVVSIFMKVSESSNPFLNRMLNRDti-------- 205 chicken
AAI07834  136 GSEDg--qGSEHLLNGQAFSGEVQLIHYNHELYTNYTEAAKSPNGLVIVSIFMKISETSNSFLNRMLNRDti-------- 205 zebrafish
AAF46521  134 GLNDq--fGSEHSVEGYTFPAEIQIFGYNSQLYANFSDALNRAQGIVGVSILLQLGDLSNAELRMLTDQLe--------- 202 fruit fly
AAF46274  124 GTENv--rGSEHFIQGYSFPGEIQIYGFNKELYHNMSEAQHKSQGIVGLSLMVQIGETPNPELRIITSTFn--------- 192 fruit fly
AAA20616  193 GRKNe--nGSEHTINGRRFPMEVQLVAYNTDLYPNFTSASKSPHGIAILSVLVDFGPETNQELIKLTIATa--------- 261 nematode
AAD08802   91 GARDg--aGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGLAILSLFVNVASTSNPFLSRLLNRDti-------- 160 human
NP_495567 108 GRADegekGSEHTVDRVRFPAEIQLLAYNSALYPNFSVAMTSPRGLLAVSVIVDIGKTTSVELRRLTVASq--------- 178 nematode
XP_784796 127 GGENt--hGSEHTVGGRAFPGELQLIFFNDDLYDSYGQAEKSPNGLAIMGLFIKTNGIVNNTGRGISFFPdpanvtyisr 204 purple urchin

AAH68462  206 --tRITYKNDAYLLQGL----------------NIEELYPEt--sSFITYDGSMTIP-PCYETASWIIMN---------- 254 human
XP_415644 206 --tRITYKNDAYLLQGL----------------NIEELYPEt--sSFITYDGSMTIP-PCYETASWIIMN---------- 254 chicken
AAI07834  206 --tRITYKNDAYLLSGL----------------NIEEVYPEt--aSFITYEGSMTIP-PCYETATWILMN---------- 254 zebrafish
AAF46521  203 ---RIRYGGDEAFVKRL----------------SIRGLLPDt--dHYMTYDGSTTAP-ACHETVTWVVLN---------- 250 fruit fly
AAF46274  193 ---KVLYRGFSTPIRHI----------------SVRSLLPNt--dHYITYEGSTTHP-GCWESTVWIIVN---------- 240 fruit fly
AAA20616  262 ---SISYKDQRVQLADF----------------EPWRLLPFt--rDIITYEGSLTSP-GCHETVTWIILN---------- 309 nematode
AAD08802  161 --tRISYKNDAYFLQDL----------------SLELLFPEs--fGFITYQGSLSTP-PCSETVTWILID---------- 209 human
NP_495567 179 ---SINYKGQTTNLTDF----------------QPSALLPKt--sHYVTYEGSLTFP-GCHETVTWVILN---------- 226 nematode
XP_784796 205 gplSYRYRLVEIRLHFGgenthgsehtvggrafPGELQLIFfnddLYDSYGQAEKSPnGLAIMGLFIKVVkltfrassip 284 purple urchin

AAH68462  255 KPVYITRMQMHSLRLLsqnqps-qiflsMSDNFRPVQPLNNRCIRTNIN 302 human
XP_415644 255 KPVYITRMQMHSLRLLsqnqps-qiflsMSDNFRPVQPLNNRCIRTNIN 302 chicken
AAI07834  255 KPIYVTKMQMHSMRLLsqnqps-qiflsMSDNVRPVQPLNNRCIRTNIN 302 zebrafish
AAF46521  251 KPIYITKQQLHALRRLmqgspd-hpkapLGNNYRPPQPLLHRPIRTNID 298 fruit fly
AAF46274  241 KPIYITKQELYQLRRLmqgses-tpkapLGNNARPVQSLHHRTVRTNID 288 fruit fly
AAA20616  310 QPIFIKKEHFEEWSHLylsmeg-aekvpVAPNFRKIQETNNRLVRTNIQ 357 nematode
AAD08802  210 RALNITSLQMHSLRLLsqnpps-qmfqsLSGNSRPLQPLAHRALRGNRD 257 human
NP_495567 227 NPIYITNDDLQIWNEMqktetkqpepsyMTPAYRPLKSLNGRLVRTNIN 275 nematode
XP_784796 285 LLLPETKEYMTSVGSIt----------tPRCTETVPWIIFNRPVYFTSY 323 purple urchin
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