Conserved Protein Domain Family
PLAT_LPL
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cd01758: PLAT_LPL 
PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the blood. In general, PLAT/LH2 domain's proposed function is to mediate interaction with lipids or membrane bound proteins.
Links
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Statistics
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PSSM-Id: 238856
Aligned: 11 rows
Threshold Bit Score: 187.984
Created: 13-Sep-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P11150    352 YHYQLKIQFINQTEtp-iqTTFTMSLLGTKEKMQKIPITLGKGIasNKTYSFLITLDVDIGELIMIKFKWENSavwanvw 430 human
BAB20997  357 YHYQLKIHFSSKVNrsemePSLTVSLYGTNGEAENLELKLKEKIatNKTHSFLLVTEKDIGDLLMLKFKWEETngwstsn 436 red seabream
CAF99587  347 HHYQFRVQFVNQMEri--qPSLTISLTGTKEESGDIPITVTEPIsgNTSLTFLITLDKDLGDLMFLKLRWDGAalwknvw 424 Tetraodon nigrovir...
AAB38649  179 FHYQVKVHFFGKTQlsytdQPMKISLYGIHGEKENIPYIMPTLNt-NSTVSFLLTTDADIGELLMVKLLWEKDtliswp- 256 zebrafish
NP_956422 351 YHYQMKMHVFDRKNaenadPTFYVKLYGSYNDSSNLIVDVTEGIglNLTNTFLVFTEEDIGELLKISLRWEGPsdswtsa 430 zebrafish
NP_957316 351 FHYQFRIQFINQIDki--dPTLTVSLSGTLGESENLPITLVEEIsgNKTFTFLITLDTDIGDLMIMRFTWEGNpvwanmw 428 zebrafish
Q9Y5X9    347 YHYQMKIHVFSYKNmgeiePTFYVTLYGTNADSQTLPLEIVERIeqNATNTFLVYTEEDLGDLLKIQLTWEGAsqswynl 426 human
AAH60756  350 FHYQMKMHIFNYKSalesePTFSVTLMGTLNDSVPLPLAVPGEIgyNFTNTFLVYTEDNIGDLLKIHLKWDGSkqmwysf 429 African clawed frog
P06858    341 FHYQVKIHFSGTESethtnQAFEISLYGTVAESENIPFTLPEVSt-NKTYSFLIYTEVDIGELLMLKLKWKSDsyfsws- 418 human
P11602    341 FHYQVKIHFFGKTNvtkvdQPFLISLYGTLDESENIPFTLPEVSs-NKTFSFLIYTEVDIGDLLMLKLQWEKDtffsws- 418 chicken
XP_697356 350 FHYQLKINFVGQINhlemdPAMTISLYGTIGETEDLKLSIQEKItsNKTHSFLVVTEKDIGDLLMLKLKMEDSsssllnl 429 zebrafish

P11150    431 dtvqt--iipwstgprhsGLVLKTIRVKAGETQQRMTFCSENTDDLll-rpTQEKIFVKC 487 human
BAB20997  437 mlkmv--sswwsgdsdgaNMEVHKIRIRAGETQQKMVFCVKDPESQk---lTQEVTFVKC 491 red seabream
CAF99587  425 krvqt--mipwggaerqaQLTVGKISIKAGETQERTTFCAMVHDEQqv-eiSQDKVFVRC 481 Tetraodon nigroviridis
AAB38649  257 -------------wwnsdTFHIRKLRIKSGETQSKIIFSAKESEFSylsrgGEAAVFVKD 303 zebrafish
NP_956422 431 ikhlgssffswssaasqkILEVRRIRVKAGETQKKFTFCAEETEISp----GEEIMFVKC 486 zebrafish
NP_957316 429 ntvkt--iipwgkkskgpQLTFGKITVKSGESQRKTTFCPQTDEGMsi-emLQEKVFVRC 485 zebrafish
Q9Y5X9    427 wkefr--sylsqprnpgrELNIRRIRVKSGETQRKLTFCTEDPENTsi-spGRELWFRKC 483 human
AAH60756  430 wnsfq--nywakndvidkELHIRRIRVKSGETQQKFTFCLENPESTll-mpGSELVFVKC 486 African clawed frog
P06858    419 ------------dwwsspGFAIQKIRVKAGETQKKVIFCSREKVSHlq-kgKAPAVFVKC 465 human
P11602    419 ------------dwwtpfAFTIQRVRVKSGETQKKVVFCSRDGSSRlg-kgEEAAIFVKC 465 chicken
XP_697356 430 lss------wwsgdptdsGLRVQKIRIRAGETQKKMVLCLKDPQTPg---lAQDFVFVKC 480 zebrafish
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