1LOX


Conserved Protein Domain Family
PLAT_LOX

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cd01753: PLAT_LOX 
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PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.
Statistics
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PSSM-Id: 238851
Aligned: 15 rows
Threshold Bit Score: 151.692
Created: 13-Sep-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1LOX        1 GVYRVCVSTGASIYAGs---kNKVELWLVGQHGEVELGSCLRpt------rNKEEEFKVNVSKyLGSLLFVRLRKKHFlk 71   rabbit
O15296      2 AEFRVRVSTGEAFGAGt---wDKVSVSIVGTRGESPPLPLDNlgke--ftaGAEEDFQVTLPEdVGRVLLLRVHKAPPvl 76   human
O75342      2 ATYKVRVATGTDLLSGt---rDSISLTIVGTQGESHKQLLNHfgrd--fatGAVGQYTVQCPQdLGELIIIRLHKERYaf 76   human
Q9BYJ1      2 AVYRLCVTTGPYLRAGt---lDNISVTLVGTCGESPKQRLDRmgrd--fapGSVQKYKVRCTAeLGELLLLRVHKERYaf 76   human
NP_001131   2 GLYRIRVSTGASLYAGs---nNQVQLWLVGQHGEAALGKRLWpa------rGKETELKVEVPEyLGPLLFVKLRKRHLlk 72   human
NP_955912   1 MEYKVTVATGTSEYSGt---nNYVYVTLIGEKGKSERTLLDNpgld--fcrGAVDDYIVKSDTdLGPLILVRLEKHKYfi 75   zebrafish
CAG11484    2 VRYHVTVSTADVVAATt---fNNVFIKLVGEDGESERRLLVSlkgaaafikGAVSKFAVHCSEsLGKLVLVELDKQQLpl 78   Tetraodon nigrovi...
XP_423676  43 AAYKVKVATGDVLEAGt---rNSIYITLVGTRGESPQKAMSYkf-----lpGKVKERTVKCEQdLGPLVLVRLTKTRLfl 114  chicken
XP_498336  24 KERNVFEQDWSLLRPGvhrglTLCQLQQLGAAVAPRWLSLLCl--------PREVEFKVQVPEhLGPLLFGKLRKRHLll 95   human
AAH81087   18 STYKLEVETGKDLLAAt---mDSISIVLIGSRGESQKQKLDHwgkd--flpGARDRYEVKSKEdLGEILVVRLYKESFgs 92   African clawed frog
1LOX       72 e-------daWFCNWISVQALgaaeDKYWFPCYRWVVG-DGVQSLPVG 111  rabbit
O15296     77 pllgplapdaWFCRWFQLTPPr--gGHLLFPCYQWLEG-AGTLVLQEG 121  human
O75342     77 fp-----kdpWYCNYVQICAPn--gRIYHFPAYQWMDG-YETLALREA 116  human
Q9BYJ1     77 fr-----kdsWYCSRICVTEPd--gSVSHFPCYQWIEG-YCTVELRPG 116  human
NP_001131  73 d-------daWFCNWISVQGPga-gDEVRFPCYRWVEG-NGVLSLPEG 111  human
NP_955912  76 e-------dnWFCRYVKVSVPge-rCCYTFPCYRWLVGdGVFVELREG 115  zebrafish
CAG11484   79 fp-----edsWFPSKVEVTSPe--gDTYHFPIYRWIDD-TKVHRFREG 118  Tetraodon nigroviridis
XP_423676 115 e-------daWFCKEVHVTAPn--gTTYHFPCHQWLEG-ITTQEFREG 152  chicken
XP_498336  96 d-------asWFCNWISVQGPgs-gEEVKFPCYLWVEG-NGVLSVPEG 134  human
AAH81087   93 fp-----esaWFCNSIKVTCPs--gEIYEFPFHLWISG-YGTFEIPQG 132  African clawed frog
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