Conserved Protein Domain Family
PLAT_polycystin
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cd01752: PLAT_polycystin 
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.
Links
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Statistics
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PSSM-Id: 238850
Aligned: 18 rows
Threshold Bit Score: 168.608
Created: 14-Sep-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9NTG1    1230 LCYLVTIFTGSrw-----------------------------------------gsGTRANVFVQLRGTVSTSDVHCLsh 1268 human
Q09624    2182 YMYVIAVETGYrm-----------------------------------------faTTDSTICFNLSGNEGDQIFRSFrs 2220 nematode
P98161    3118 FKYEILVKTGWgr-----------------------------------------gsGTTAHVGIMLYGVDSRSGHRHLdg 3156 human
XP_414854 3468 YKYEILVKTGWgrgsaaargndpvqkypycspclqeqprdidcssllvlscrsiqaCTTAHVGIALYGVDNKSGHRHLdg 3547 chicken
Q8TDX9    1796 QLYAVVIDTGFra-----------------------------------------paRLTSKVYIVLCGDNGLSETKELsc 1834 human
AAT77543  2703 FKYKVLVKTGWgr-----------------------------------------gsGTTAHVGISLYGVDYKSGHRHLdg 2741 African clawed frog
XP_780860 2864 QYYDITVETGFrs-----------------------------------------gaGTTARISIVLHGEEGHSETKELic 2902 purple urchin
XP_694060 1710 YQYRVLVKTGWkr-----------------------------------------gsGTTAHVGISLYGLNKSGSRHLQrq 1748 zebrafish
NP_999801 1530 YLYNVTVVTGFrr-----------------------------------------gsGTTATVTLTLTGKEGQSDPHVLhd 1568 purple urchin
XP_784368  504 YYYEIVVMTGQrk-----------------------------------------agGTDSKVSFIMSGENEETSVRDFed 542  purple urchin

Q9NTG1    1269 phf----ttlyRGSINTFLLTTKSDLGDIHSIRVWHNNEGr--sPSWYLSRIKVENLfsrhIWLFICQKWLSVd-----t 1337 human
Q09624    2221 eedgnwefpfsWGTTDRFVMTTAFPLGELEYMRLWLDDAGldhrESWYCNRIIVKDLqtqdIYYFPFNNWLGTkng--dg 2298 nematode
P98161    3157 dr------afhRNSLDIFRIATPHSLGSVWKIRVWHDNKGl--sPAWFLQHVIVRDLqtarSAFFLVNDWLSVeteangg 3228 human
XP_414854 3548 en------afhRNSLDVFQIATERNLGSIWRIRIWHDNKGl--sPSWYLQHVIVRDLqsskSYFFLVNDWLSVeseendg 3619 chicken
Q8TDX9    1835 pek----plfeRNSRHTFILSAPAQLGLLRKIRLWHDSRGp--sPGWFISHVMVKELhtgqGWFFPAQCWLSAgrh--dg 1906 human
AAT77543  2742 dn------tfhRNSVDIFQIATEKNLGNIWKIRLWHDNKGl--sPSWYVQHVIIRDLqsnkEYFFLVNDWLSVgreesgr 2813 African clawed frog
XP_780860 2903 edk----pifeNNSRDRFIISVPESLGNIQRLQLWHNNAGl--sPGWYLSRISIRDLltgqKWFFICERWFAVeed--dg 2974 purple urchin
XP_694060 1749 g-------afqRNSMDDFQVETDANLGEIWKIRIWHDNTGl--dPSWYLQHVIVWDIqtenMFFFLVEDWLSVeneknsg 1819 zebrafish
NP_999801 1569 sfs----pildRGSTDSFLLTTAKGLGDIQALRLWHNNAGs--sPNWYVSHCIVHDLesdeRYYFICNSWMMVefg--gv 1640 purple urchin
XP_784368  543 dkr----kifrRGASDRFLMAVPGPLGTLNYMRIWHDNSGkgkmQGWYVKYIAIRDIqtreRFYFIVNQWFSVved--dg 616  purple urchin

Q9NTG1    1338 TLDRTFHVT 1346 human
Q09624    2299 ETERLARVE 2307 nematode
P98161    3229 LVEKEVLAA 3237 human
XP_414854 3620 MVEKEVYAA 3628 chicken
Q8TDX9    1907 RVERELTCL 1915 human
AAT77543  2814 RVEREIFAA 2822 African clawed frog
XP_780860 2975 KIERELLVV 2983 purple urchin
XP_694060 1820 RVEKVILAS 1828 zebrafish
NP_999801 1641 GLDNTFHIA 1649 purple urchin
XP_784368  617 QIDRLIPVA 625  purple urchin
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