1M2O


Conserved Protein Domain Family
Sec23-like
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cd01478: Sec23-like 
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Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 23 is very similar to Sec24. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup lack the consensus MIDAS motif but have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Links
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Statistics
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PSSM-Id: 238755
Aligned: 9 rows
Threshold Bit Score: 446.817
Created: 10-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:vWA-Sar 1 interaction
Evidence:
  • Structure:1M2OA:structure of sec23/24-sar1 complex
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1M2O_A    119 TVPPIFFFVVDLTSETENLDSLKESIITSLSLLPPNALIGLITYGNVVQLHDLSSETIDRCNVFRGDREYQLEALTEMLT 198 baker's yeast
12718409  127 PAPPIFLYVVDTCQEEDSLAALKESLIMSLSLLPEHALVGLITYGTMAQVHEIGYTECPKSYVFRGNKEYAAKQVQEMLG 206 Neurospora crassa
3702631   120 QLTPVFLFVVDVCQDEENLQALKDSLIISLSLLPPECLVGLVTFGTMVDVYELGYTECSKSYVFRGSKDYTSKQIQEMLG 199 fission yeast
20141794  126 QSPLIFLYVVDTCLEEDDLQALKESLQMSLSLLPPDALVGLITFGRMVQVHELSCEGISKSYVFRGTKDLTAKQIQDMLG 205 human
4567227   124 PSPPVFLFVVDTCLISEELDFLKSSLFQALDLLPDTSILGLITFDSLVRVYELGFPHCTKSYFFHGNKDCTKDQLLDQLS 203 thale cress
14530602  130 TMPPIFVFVVDTCMTAEELKSLKECLQTALSLLPADALVGLITYGRMVQLHELNTQGISRSYVFKGTKEVTAKQIKDVMA 209 Caenorhabditis ele...
4176521   120 KSPPVFLFVMDTAVDESELTALKDAVIVSLSLLPPDAIVGLITYGSLIQVHEIGFEAMPKSYVFQPAADYSTMKLQQLLA 199 fission yeast
7271162   126 TMPPVFIFLVDTCMDEEELDALKDSLQMSLSLLPTNALVGLITFGKMIQVHELGAEGCSKSYVFRGTKDLTAKQVQDMLG 205 fruit fly
2244772   128 PPPPVFVFVLDTCMIEEELGYAKSALKQAIGLLPENALVGFVSFGTQAHVHELGFSEMSKVFVFKGNKEVTKDQILDQLG 207 thale cress

Feature 1                                                                                     
1M2O_A    199 Gqkptgpggaash------------------------------------------------lpnamnkvtpfsLNRFFLP 230 baker's yeast
12718409  207 Lvqpamrpgmpm--------------------------------------------------qqpgrpfpagpASRFLLP 236 Neurospora crassa
3702631   200 Lptsnvspvalq---------------------------------------------------qarsfqgsaaPSRFLLP 228 fission yeast
20141794  206 Ltkpampmqqar---------------------------------------------------paqpqehpfaSSRFLQP 234 human
4567227   204 Ffvknpkpssgvi-------------------------------------------------agardglssddIARFLLP 234 thale cress
14530602  210 GgglsqrpaagapgapagapgapmamgsgaaplgqlpgsglpgglprgggpplpgaaqgivapgggapvphapANKFLQP 289 Caenorhabditis ele...
4176521   200 Lsgnqirsssskak-----------------------------------------------isgtgitlnlgaASRFLMP 232 fission yeast
7271162   206 Igrraapgpqqqq-------------------------------------------------hlpgqpagaaaPVRFLQP 236 fruit fly
2244772   208 Lgsssrraptsgf------------------------------------------------skgaqngfqssgVDRFLLP 239 thale cress

Feature 1                             #                                                ## ## #
1M2O_A    231 LEQVEFKLNQLLENLSPDQWSVPAGHRPLRATGSALNIASLLLQGCYKNIPARIILFASGPGTVAPGLIVNSELKDPLRS 310 baker's yeast
12718409  237 VSQAEFQLTKAIEQLQKDPWPVAGNLRALRCTGVALSVAVGLLETSFQNAGGRIMLFAGGPATEGPGMVVGPELREPIRS 316 Neurospora crassa
3702631   229 IQQCEFQLTNILEQLQPDSWPVANDRRPQRCTGTALNISVSMMESVCPNSGGHIMLFAGGPSTVGPGTVVSTELREPIRS 308 fission yeast
20141794  235 VHKIDMNLTDLLGELQRDPWPVTQGKRPLRSTGVALSIAVGLLEGTFPNTGARIMLFTGGPPTQGPGMVVGDELKIPIRS 314 human
4567227   235 ASDCHFTLHSVLEELGNSPWPVAADHRPARCTGVALRIAASLLGACFPGSAARIMAFIGGPSTQGPGAIVSRELSDPIRS 314 thale cress
14530602  290 ISECDESINDLIDQISIDRWPVPQGHRPLRATGAALAVAVTLLESCFPSTGARIMSFIGGACTHGPGAVVGEELKNPIRS 369 Caenorhabditis ele...
4176521   233 VQKCEMHLLNILEQLQPDCLEVPAGQRQLRCTGAAVKIASDLLGIAFPKCGSRIELFCGGPCTVGLGQVVSTELKEPMRS 312 fission yeast
7271162   237 IGQCDAALGDLLSELQRDPWPVPQGKRYLRSTGAALSIAVGLLECTYPNTGGRIMTFVGGPCSQGPGQVVDDELKHPIRS 316 fruit fly
2244772   240 ASECEYTLDLLLDELQSDQWPVQPGHRPQRCTGVALSVAAGLLGACLPGTGARIVALVGGPCTEGPGTIISKDLSDPVRS 319 thale cress

Feature 1      ##    #                              ###                                   
1M2O_A    311 HHDIDSDHAQHYKKACKFYNQIAQRVAANGHTVDIFAGCYDQIGMSEMKQLTDSTGGVLLLTDAFSTAIFKQSYLR 386 baker's yeast
12718409  317 HHDIDRDNIKYYKKALKFYDNLAKRTAHNGHTIDIFAGCLDQVGLLEMKGLCNSTGGHMILTDSFTSSMFKQSFVR 392 Neurospora crassa
3702631   309 HHDIERDQAKHVKKALRFYEGLTKRVSANGHAVDILAGCLDQIGIMEMKSLASSTGGYLVLSDSFTTSIFKQSFQR 384 fission yeast
20141794  315 WHDIEKDNARFMKKATKHYEMLANRTAANGHCIDIYACALDQTGLLEMKCCANLTGGYMVMGDSFNTSLFKQTFQR 390 human
4567227   315 HKDIDKDSAMYYHKAVEFYEMLAKQLVHQGHVLDVFASSVDQVGIAELKVAVEQTGGFVVLAESFGHSVFRDSLKR 390 thale cress
14530602  370 WNSIKEDAAPYMKKAIKFYDGLAARIVKNGHAVDVYSCALDQTGLLEMKNMFNSSGGHVVMGDSFNSSLFKQTYQR 445 Caenorhabditis elegans
4176521   313 HSEIANDKAKHFKKSKKFYSSLAERLSNQGHALDLFAGCLDQVGIMEMENLVNNTGGAIVLSDSFTTSIFKQSFQR 388 fission yeast
7271162   317 HHDIHKDNVRFMKKAIKHYDALALRAATNGHSVDIYSCALDQTGLLEMKQLCNSTGGHMVMGDSFNSSLFKQTFQR 392 fruit fly
2244772   320 HKDLDKDAAPYYKKAVKFYDSIAKQLVAQGHVLDLFASALDQVGVAEMKVAVESTGGLVVLSESFGHSVFKDSFKR 395 thale cress

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