1N0W


Conserved Protein Domain Family
Rad51_DMC1_radA
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cd01123: Rad51_DMC1_radA (this model, PSSM-Id:238543 is obsolete and has been replaced by 410868)
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Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar recombination reaction as RecA, using ATP-dependent DNA binding activity and a DNA-dependent ATPase. However, this reaction is less efficient and requires accessory proteins such as RAD55/57 .
Links
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Statistics
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PSSM-Id: 238543
Aligned: 42 rows
Threshold Bit Score: 191.258
Created: 7-Mar-2002
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                #   ##                        # # #                  
1N0W_A      6 ITTGSKELDKLLQGGIETGSITEXFGEFRTGKTQICHTLAVTCQlpidrgggegkAXYIDTEGTFRPERLLAVAErygl- 84  human
BAB32931   90 INTGSADLNNILGGGIHCKEVTEIGGVPGVGKTQLGIQLAINVQipveygglggkAVYIDTEGSFMVERVYQIAEgcisd 169 Japanese rice
O43502    100 IITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQipecfggvageAVFIDTEGSFMVDRVVDLATaciqh 179 human
O15315     83 LSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATlptnmgglegaVVYIDTESAFSAERLVEIAEsrfpr 162 human
AAH52122   79 FSTSLPALDRLLHGGLPRGALTEVTGPSGCGKTQLCMMLSVLATlpkslggldsgVIYIDTESAFSAERLVEMAQsrfpe 158 zebrafish
AAL27842   93 IISMARDLDALLGGGVAAGQVTEFCGVPGVGKTQLGMQLAVNVQiprslsgpegqAVYIDTEGSFMAERCADIAEgavrh 172 Chlamydomonas rein...
Q9UUL2     75 LTTGDVKLDETLHGGIPVGQLTEICGESGSGKSQFCMQLCLMVQlplslggmnkaAVFISTESGLETKRLFELARylper 154 fission yeast
P25301    100 FTTADVAMDELLGGGIFTHGITEIFGESSTGKSQLLMQLALSVQlsepagglggkCVYITTEGDLPTQRLESMLSsrpay 179 baker's yeast
NP_560594  82 KTGVAEFDEKTPWRGIREAFIYEFAGEFGAGKSMLAHQASVAALregf----terVVYIDTEGTFNEALIEAVARrfel- 156 Pyrobaculum aeroph...
3914533    83 LSTTLCALDEALHGGVPCGSLTEITGPPGCGKTQFCIMMSVLATlptslgglegaVVYIDTESAFTAERLVEIAEsrfpq 162 house mouse

Feature 1                                                                         #           
1N0W_A     85 ------------------------sgsDVLDNVAYARAFntDHQTQLLYQASAXXVes---ryALLIVDSATALYRtdys 137 human
BAB32931  170 ileyfphch-----dkapagqeklkpeSFLADIYYFRICsyTEQIAVINYLEKFLGehk--dvRIVIIDSVTFHFRqdfd 242 Japanese rice
O43502    180 lqliaekhk----geehrkaledftldNILSHIYYFRCRdyTELLAQVYLLPDFLSehs--kvRLVIVDGIAFPFRhdld 253 human
O15315    163 yf------------------nteekllLTSSKVHLYRELtcDEVLQRIESLEEEIIsk---giKLVILDSVASVVRkefd 221 human
AAH52122  159 ff------------------svkerllEMAARVHLFRELtcQDVLKRLERLEEDIIac---raGLVILDSVASVVRkefd 217 zebrafish
AAL27842  173 vqsilekkasmgqpellhdgerpftleNVMRGIYLFRVHdhVEQLGLVNMLPRFLEqys--qvRLIVIDSVTFHFRqdfp 250 Chlamydomonas rein...
Q9UUL2    155 ypka---------------dkkdiiikNPGDRVYTILCPdlESQEHIIQYQLPILFnrd--kiGLVILDSVASNYRaelr 217 fission yeast
P25301    180 -----------------------eklgITQSNIFTVSCNdlINQEHIINVQLPILLerskgsiKLVIIDSISHHLRvelq 236 baker's yeast
NP_560594 157 ------------------------dveRIADSIYVYQPAnvVQLEQIVKFDVPKHIqe---gcRLLVIDTITALYRaefv 209 Pyrobaculum aeroph...
3914533   163 yf------------------nteekllLTSSRVHLCRELtcEGLLQRLESLEEEIIsk---gvKLVIVDSIASVVRkefd 221 house mouse

Feature 1                                                                                     
1N0W_A    138 grge---------lsarqxhLARFLRXLLRLADEFGVAVVITNQVvaqvdgaa--------------------------- 181 human
BAB32931  243 dm------------alrtrvLSGLSLKLMKLSKAYNLAVVLLNQVttkfte----------------------------- 281 Japanese rice
O43502    254 dl------------slrtrlLNGLAQQMISLANNHRLAVILTNQMttkidr----------------------------- 292 human
O15315    222 aqlqg-------nlkernkfLAREASSLKYLAEEFSIPVILTNQItthlsgalasqadlvsp------------------ 276 human
AAH52122  218 tslpg-------nlthrsnfLGQEAAVLKYLSQEFCIPVVLTNQItthvgeklhcpqwn--------------------- 269 zebrafish
AAL27842  251 dm------------aqrtrvVTGMAQQLISLAQTHNVAVVLMNQVttkvleg---------------------------- 290 Chlamydomonas rein...
Q9UUL2    218 ynrskshfrdldniakrgnqLGKLAMTLRTLAHQHEAAVVIANQVsdriprdydaiglfsldy----------------- 280 fission yeast
P25301    237 nksfr-------esqenknyLDRMAEKLQILAHDYSLSVVVANQVgdkplanspvahrtyvtdydyqlgwlvgwknstil 309 baker's yeast
NP_560594 210 grey---------latrqqrIHYLVDWLRRHARTFGLTTVLTNQVmdvpeif---------------------------- 252 Pyrobaculum aeroph...
3914533   222 pklqg-------nikernkfLGKGASLLKYLAGEFSIPVILTNQItthlsgalpsqadlvsp------------------ 276 house mouse

Feature 1                                                                                     
1N0W_A    182 --------------------------------------------------------------------xfaadpkkPIGG 193 human
BAB32931  282 ----------------------------------------------------------------------gsfqltLALG 291 Japanese rice
O43502    293 ----------------------------------------------------------------------nqallvPALG 302 human
O15315    277 -----------------------------------------------------------addlslsegtsgsscviAALG 297 human
AAH52122  270 --------------------------------------------------------------qtdasfeedsgfvtAALG 287 zebrafish
AAL27842  291 ----------------------------------------------------------------------ggsklvPALG 300 Chlamydomonas rein...
Q9UUL2    281 -----------------------------------------------------------qsqwfsgwddtdpnpkiPSLG 301 fission yeast
P25301    310 yrqmnsllgassnndeilsddedymliervmstvndrnydffskkkppiienktvernssspisrqskkrkfdyrvPNLG 389 baker's yeast
NP_560594 253 ----------------------------------------------------------------------aagvkrPAGG 262 Pyrobaculum aeroph...
3914533   277 -----------------------------------------------------------addlslsegtsgssclvAALG 297 house mouse

Feature 1                                                                           
1N0W_A    194 NIIAHASTTRLYLRKGr-----------------------gETRICKIYDSPCLP-EAEAXFAINADGVG 239 human
BAB32931  292 DSWSHSCTNRLILYWNg------------------------NERYGFLDKSPSLP-VASAPYAVTVKGVR 336 Japanese rice
O43502    303 ESWGHAATIRLIFHWDr------------------------KQRLATLYKSPSQK-ECTVLFQIKPQGFR 347 human
O15315    298 NTWSHSVNTRLILQYLd-----------------------sERRQILIAKSPLAP-FTSFVYTIKEEGLV 343 human
AAH52122  288 NTWSHSVNTRLIVQYEd-----------------------sERRQIVIAKSPVAP-FAVLSYTIQKEGIR 333 zebrafish
AAL27842  301 ESWGHAASTRVMLTWGp-----------------------dNERHAQMIKSPHLP-LGDAAFAVTADGLR 346 Chlamydomonas reinhardtii
Q9UUL2    302 LVWTNNISTRLALIKKtdsa------------------tnnSGRIFRVVYSPNSP-RLDVRICIGSVGIY 352 fission yeast
P25301    390 LTWSNHVSTRILLQKSfkastiiqrgeahlykggdsasfwqVKRTMKVVYSTFAK-PGQIAYQITKRGIE 458 baker's yeast
NP_560594 263 NVLAHAVNARFMMVRPnk---------------------tkPEGYIWPLDVPGMApDIRIEYRITGAGLE 311 Pyrobaculum aerophilum str. IM2
3914533   298 NTWGHCVNTRLILQYLd-----------------------sERRQILIAKSPLAA-FTSFVYTIKGEGLV 343 house mouse

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