1JEY,1JEQ


Conserved Protein Domain Family
KU80
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cd00873: KU80 
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Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the regulation of all the diverse functions of Ku is still unclear, although it seems that Ku is a multifunctional protein that works in nuclei. In mammalian cells, the Ku heterodimer recruits the catalytic subunit of DNA-dependent protein kinase (DNA-PK), which is dependent on its association with the Ku70/80 heterodimer bound to DNA for its protein kinase activity.
Links
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Statistics
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PSSM-Id: 238445
Aligned: 36 rows
Threshold Bit Score: 177.097
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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DNA bindingheterodimer
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                            #                                        
1JEY_B    244 SIHWPCRLTIGSn------------------LSIRIAAYKs------------------ILQERVk-------------- 273 human
NP_982917 204 VRVFHGQLRLGAdmrnlag-----cqqdphcLCINVEGYPa------------------TKAVVS--------------- 245 Eremothecium gossypii
CAJ05844  244 QPVLKVALRMGD-------------------VRLATQLFTl------------------TQEERLp-------------- 272 Leishmania major
CAG85021  228 MRAFKGQLRFGSdhcnqnensdyapeldqtcISLNVELYPa------------------LKAEKLasghqytidpangsv 289 Debaryomyces hanse...
XP_813890 230 RALLRVVLSIGD-------------------VRLATQMFTk------------------TQEERLp-------------- 258 Trypanosoma cruzi ...
CAH02488  203 IRTFQGQLRLGDvnasd---------lgipsLCINLEGVPg------------------TKSVSS--------------- 240 Kluyveromyces lact...
NP_013824 244 VEAFPATKAVSGl-----------------nRKTAVEVEDs------------------QKKERYv-------------- 274 baker's yeast
CAG61335  255 VQGYPATKKTGS-------------------LQKKTVVKDa------------------SKPGFV--------------- 282 Candida glabrata C...
CAC86188  197 TVLYTLCKALGNds---------------rvITLRDALVSaaqlvcrkvrslaqktvftIGEVRLatnv---------lg 252 Trypanosoma brucei
CAL54739  278 TAGFRGALSFGFn------------------ARVNVSLYKl------------------NAEAAPa-------------- 307 Ostreococcus tauri

Feature 1       ##                          #                                                 
1JEY_B    274 -KTWTVVDa------kTLKK------EDIQKETVYclnd---------------------------ddetEVLK-----E 308 human
NP_982917 246 -MSRKQVQ--------KTEDgk---yLPLQSVIEYeiheptee-------------------dneeyhvvPVPK-----E 289 Eremothecium gossypii
CAJ05844  273 -SLRRSTQ--------DGVDv----aQTIEYVVLGgvee----------------------------rpcALAK-----E 306 Leishmania major
CAG85021  290 dKTKYVKDyfiklvssKDEDgkd-ddEEVQKRRYDdddddedk--------------------dgdletvSIDA-----N 343 Debaryomyces hanse...
XP_813890 259 -TMKRTTA--------NGEEvy---mKTIFQDLSEda--------------------------------aPLRK-----E 289 Trypanosoma cruzi ...
CAH02488  241 -ISRKVMRkeg---ssEGQPt----yRAVKSVIEYqiedqsastsaspkkettrkdddgdsgnntgprmiNVSK-----D 307 Kluyveromyces lact...
NP_013824 275 -GVKSIIEye-----iHNEGnkknvsEDDQSGSSYip--------------------------------vTISK-----D 311 baker's yeast
CAG61335  283 -PVKSVIDy-------ELRD------NEVEGEGKGkgegd--------------------------appiTVAR-----E 317 Candida glabrata C...
CAC86188  253 kVRRMHVPan-----rTPAPt-----ERVPGSRKAahsq---------------------------lfdeETLRleggeE 295 Trypanosoma brucei
CAL54739  308 -KLNKYSEel-----aHRPE------ESHKTMIDVafrnv-------------------------ndldgELVPv----E 346 Ostreococcus tauri

Feature 1                         #              #                     #                      
1JEY_B    309 DIIQGFRYG----SDIVPFSKvdeeQMKYKSe--GKCFSVLGFCKSSQVQRRFFMgnQVLKVFAAr----------dDEA 372 human
NP_982917 290 HVTKAYRYG----ADYVVLPEllehERLYTT---TPGLDIRGFIDTGKVLRHHLCs-ESVYIMADsr--------egTAA 353 Eremothecium gossypii
CAJ05844  307 ERVEAFFLG----VDRISCSEad-rEAMRVKg--PRALEAIGFVGEAEVEPYLLMg-GTRALLPLa----------gDHA 368 Leishmania major
CAG85021  344 EWTDGFKYSn---YDLLTLDEdl-lNSAKLAs--DPGMDILGFIKMDDLPYAYLTg-ESYYLLPEvs---------cSYK 407 Debaryomyces hanse...
XP_813890 290 DLLKGYHYG----RSLVPCARed-vGAMKIKg--PRAMDAVGFVPIQQVPAYVLLg-GVKVIMPLa----------dDMV 351 Trypanosoma cruzi ...
CAH02488  308 FIKKAYRYG----ADYVDLPMpl-dEERKLSe--KPGLDIRGFMDIDKLPRHYLCs-ESMYLVPDsk--------ngSKG 371 Kluyveromyces lact...
NP_013824 312 SVTKAYRYG----ADYVVLPSvl-vDQTVYEs--FPGLDLRGFLNREALPRYFLTs-ESSFITADtr--------lgCQS 375 baker's yeast
CAG61335  318 SITKAYRYG----TDYVVLPSsl-eDQLVYQt--YAGLDIRGFMNMSDMHRHFLTs-ESVFVVSSs-----------SSA 378 Candida glabrata C...
CAC86188  296 DSQKTCLETpvnkPTASSSNRl--sEATKIRg--SRGIDAVACIPQNQVPVHVLVv-DTSYMIAPld---------dDPV 361 Trypanosoma brucei
CAL54739  347 RHVKAYRYG----KQHVPVDAe---TENRLSarfEKGMKVIGSIRASEAPAWLVTg-EPSLCVPQqsskttglskerADA 418 Ostreococcus tauri

Feature 1                             ##### #                                          #      
1JEY_B    373 AAVALSSLIHALDDLDMVAIVRYAYDKRA-NPQVGVAFPHIKhn--------------yECLVYVQLPFMEDLRQYMFSS 437 human
NP_982917 354 DYVTFAALVDAMIAAEKFAIARYVQKKDS-EVQMCLLCPLLVepstkkrpadddaaeakRALVLCRLPFAEDERSSDFPP 432 Eremothecium gossypii
CAJ05844  369 GQRGFNALVDAMASSRKAMLVRLVRTADA-APSLCVCFARTAgss-----------aaqRHLVLAPLPFAEDVRALRFSE 436 Leishmania major
CAG85021  408 NLVGFNGLCQSLVDLEGLALIRYVQKPND-EIKVCILIPSKIkvne----------sfvYAFILVRLPFREDEKIGKFPL 476 Debaryomyces hanse...
XP_813890 352 GAKAFRSIVRAIAADNRAMIVRFVRTRDA-DPVLGLCVPSTNer--------------rDVLFFSPLPYAEDVRFFEFSD 416 Trypanosoma cruzi ...
CAH02488  372 DFLGFVTLVDSLIKMKRLIIARFVPKFGN-EVQMCSLFPVRVhdkd---------rnevRLLVLNRLPMSEDERNSAFPK 441 Kluyveromyces lact...
NP_013824 376 DLMAFSALVDVMLENRKIAVARYVSKKDS-EVNMCALCPVLIehsnin-----sekkfvKSLTLCRLPFAEDERVTDFPK 449 baker's yeast
CAG61335  379 DQITFSALIDAMIQIDKIAIGRYVPKNNS-DVQMCMLYPMILeken---------gthvRTLILNRLPFTEDERIAIFPR 448 Candida glabrata C...
CAC86188  362 GTRAFRSIVKALAAQDSALVVRYVRSTDG-NPNMFLCVPLTTgd--------------eDVLFMSRLPFMEEIRCLRFPT 426 Trypanosoma brucei
CAL54739  419 DARALSALARALDDAGLALLVRGAWTESTsTIHIGALTPRISde--------------gDFLLFTPLPFKEDYNEYALPP 484 Ostreococcus tauri

Feature 1                                                                                     
1JEY_B    438 LKnskk------------------------------yapTEAQLNAVDALIDSMSLakkdekt---------------dt 472 human
NP_982917 433 LVkqe--------------------------------paDVMLDTTMAAFIDSMDMdaaappaswcs-------ssnvrs 473 Eremothecium gossypii
CAJ05844  437 YPel---------------------------------qfSAAEEQLMDELIDGLSVdd---------------------- 461 Leishmania major
CAG85021  477 LTsimttsgksftsntdspdenpikqendeessnetnlpNAATNSLMESFILSRDLd----------------------- 533 Debaryomyces hanse...
XP_813890 417 YKgmwgts--------------------------sddgdDGEEARLLAAIVEDMTVgk---------------------- 448 Trypanosoma cruzi ...
CAH02488  442 MCes---------------------------------teLEPEDEAMGQFVDSMNLdndaqdlpwye------sdqiqky 482 Kluyveromyces lact...
NP_013824 450 LLdrtttsgv----------------------plkketdGHQIDELMEQFVDSMDTdelpeiplg----------nyyqp 497 baker's yeast
CAG61335  449 LTreddk----------------------------ksekDETIDQLMAGFVESRSMddlprveek----------kyyef 490 Candida glabrata C...
CAC86188  427 LQememec-------------------------dipeadAQREQELVSSIVEEMTVgeevlhphrvlnpfvqqyyatqra 481 Trypanosoma brucei
CAL54739  485 APpgar------------------------------ieaSDPRLDSALDFVRANALgd---------------------- 512 Ostreococcus tauri

Feature 1                                                                                     
1JEY_B    473 ledlFPTTKIPNPr-------FQRLFQCLLHRALHp--------------rEPLPPIq---------------------- 509 human
NP_982917 474 fdsfMKDSTLPLPddps-laePCSAAACIPAVALHhqkh---------vllEYFHQRfilrlnn---------gfsvadl 534 Eremothecium gossypii
CAJ05844  462 --svLAPHDTFNPv-------LQQYYATLRAKLSAmnvsaekgntkatspeAAVPQLlpt------------------lr 514 Leishmania major
CAG85021  534 ----TKGKNKDNEsndsdtffVENNKVTLSNDSLIs---------------FPKLSHf---------------------- 572 Debaryomyces hanse...
XP_813890 449 --svLRPRETFNPv-------IQQYYATLRAKLRLf--------------cDGRGAVggkgscgagelrgekngekntng 505 Trypanosoma cruzi ...
CAH02488  483 tdvaLEQSSLPLPq-------REMFRATARNPSAIp--------------aISLHRQq---------------------- 519 Kluyveromyces lact...
NP_013824 498 igevTTDTTLPLPsln--kdqEENKKDPLRIPTVFvyrqq-------qvllEWIHQLmind----------------sre 552 baker's yeast
CAG61335  491 yedsVRDTTLVLP--------MKSKDETRERDPLMvp-------------aMGLHRQl---------------------- 527 Candida glabrata C...
CAC86188  482 mvnrWCSRTAENPl-------SAHEDSDIKLALLP----------------QLRGISa---------------------g 517 Trypanosoma brucei
CAL54739  513 --daTMPWESLNPt-------LRDQRRLFEARALG----------------EHATAIe---------------------- 545 Ostreococcus tauri

Feature 1                                                                    
1JEY_B    510 QHIWNMLNPpae--------------vttKSQIPLSKIKTLF---------------PLIEAK 543 human
NP_982917 535 RDSLRSKVSpwa---------------taETSELAARIKDTC---------------AVKLVE 567 Eremothecium gossypii
CAJ05844  515 GTSTDFFAEgsevy-----------evvsAHRSALVSCATAFpy------------eDEADAL 554 Leishmania major
CAG85021  573 GVSSRLLVSspa---------------ihKFNLNIKKIIIKSle-----------dgNLHEYL 609 Debaryomyces hansenii CBS767
XP_813890 506 EVLLPLVGAieatsaafgvpgnqlesvlsSVREKLEACARSFvyvs-------nrenCVAEER 561 Trypanosoma cruzi strain CL Brener
CAH02488  520 QVILECVHQkfivgkrd----qqdlnippMSKMILKKITPKYnadv-------slsnRIKEQF 571 Kluyveromyces lactis NRRL Y-1140
NP_013824 553 FEIPELPDSlk-----------------nKISPYTHKKFDST---------------KLVEVL 583 baker's yeast
CAG61335  528 QVMLEYLHQvvinks--------ekfdppELQDHLKAKITPHivsdfpeleelvnllELKKVE 582 Candida glabrata CBS 138
CAC86188  518 FASPGCKVEql----------------vsRTREKLETCCRVFayvpr-----ttshsPERKVL 559 Trypanosoma brucei
CAL54739  546 PTALEFAVAeaps-------------vafAKRFNLDAGPGPGpgpg--------pseRVKMPR 587 Ostreococcus tauri

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