1DFC,1DFC,1DFC,1DFC,1HCD


Conserved Protein Domain Family
Fascin
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cd00257: Fascin (this model, PSSM-Id:238160 is obsolete and has been replaced by 467441)
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Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an internal threefold repeat; the fascin subgroup contains four copies of the domain; Structurally similar to fibroblast growth factor (FGF)
Links
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Statistics
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PSSM-Id: 238160
Aligned: 40 rows
Threshold Bit Score: 79.2412
Created: 4-Sep-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PKC
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:PKC phosphorylation site [posttranslational modification site]
Evidence:
  • Comment:phosphorylation site is present only in domain 1 of fascin-like proteins
  • Comment:regulates the actin binding ability of fascin
  • Comment:Ser to Ala mutation abolishes actin binding
  • Citation:PMID 8999969
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                 #                                                   
1DFC_A     11 QIQFGLINcgNKYLTAEAFgfKVNASASSLkkkQIWTLEQppdeagsAAVCLRSHLGRYLAAdkdgNVTCerev--pgpD 88  human
1HCD        1 MGNRAFKShhGHFLSAEGE--AVKTHHGHHdhhTHFHVENh-----gGKVALKTHCGKYLSIgdhkQVYLshhl--hgdH 71  Dictyostelium disc...
P42526      1 MGNRAFKAhnGHYLSAEHDhvKTHHGHHDHh--THFHIENh-----gSKVALRTHCGKYVSIgdhkQVYLshhl--hgdH 71  Dictyostelium disc...
2498359     7 KYKFGLVNsaGRYLTAEKFggKVNASGATLkarQVWILEQee---ssTISYLKAPSGNFLSAdkngNVYCsvedrtedaD 83  Strongylocentrotus...
2498913    24 WWTIGLINgqHKYMTAETFgfKLNANGASLkkkQLWTLEPsnt--geSIIYLRSHLNKYLSVdqfgNVLCesde--rdaG 99  fruit fly
AAL49381   76 WWTIGLINgqHKYMTAETFgfKLNANGASLkkkQLWTLEPsnt--geSIIYLRSHLNKYLSVdqfgNVLCesde--rdaG 151 fruit fly
Q9NQT6     15 DLRVGLISwaGTYLTFEACknTVTATAKSLgrrQTWEILVsnehetqAVVRLKSVQGLYLLCecdgTVCYgrpr--tshH 92  human
Q9NQT6    263 PTWVSLRSktGRFISVIYDg-EVRAASERLnrmSLFQFECds---esPTVQLRSANGYYLSQrrhrAVMAdgh---pleS 335 human
Q9QXW4     15 DLRVGLISwaGTYLTFEAYksSVTASAKSLgrrQTWELLVsnehesqAVIRLKSLQGLYLLCeadgTVCYgrpr--tshH 92  house mouse
Q9QXW4    263 PTWVSLKSksRRFLSVIYDa-EVCAASERLtqmSLFQYECds---etPTLQLRSANGYYLAQrrhrAIIAdgh---pmeS 335 house mouse

Feature 1                                                       
1DFC_A     89 CRFLIVAHd--dGRWSLQSeaHRRYFGGt-eDRLSCFaqt-vspAEKWSV 134 human
1HCD       72 SLFHLEHHg---GKVSIKGh-HHHYISAdhhGHVSTKehh--dhDTTFEE 115 Dictyostelium discoideum
P42526     72 SLFHLEHHh---GKVSIKGh-HHHYISVdghGHVSTShhh--dhHATFEE 115 Dictyostelium discoideum
2498359    84 TGFEIELQp--dGKWALKNvsHQRYLACn-gEELICSesstsnpSANWTV 130 Strongylocentrotus purpuratus
2498913   100 SRFQISISedgsGRWALKNesRGYFLGGt-pDKLVCTakt-pgaSEFWTV 147 fruit fly
AAL49381  152 SRFQISISedgsGRWALKNesRGYFLGGt-pDKLVCTakt-pgaSEFWTV 199 fruit fly
Q9NQT6     93 GCFLLRFHr--nSKWTLQCliSGRYLESn-gKDVFCTshv-lsaYHMWTP 138 human
Q9NQT6    336 DTFFRMHWn--cGRIILQSc-RGRFLGIapnSLLMANvil-pgpNEEFGI 381 human
Q9QXW4     93 GCFLLRFHr--nGKWTLQCiiSGRYLESd-gEDVFCNsrv-lsaYHMWTP 138 house mouse
Q9QXW4    336 DTFFRVHWn--cGKITLQSp-NGRFLGIasdGLLMANvti-pgpNEELGI 381 house mouse

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