1ICF


Conserved Protein Domain Family
TY

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cd00191: TY 
Click on image for an interactive view with Cn3D
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
Statistics
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PSSM-Id: 238114
Aligned: 85 rows
Threshold Bit Score: 42.0657
Created: 2-May-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
protease
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:protease interaction site
Evidence:
  • Comment:loops are not conserved, their sequences determine specificity of thyroglobulin type I inhibitors for various proteases
  • Comment:loop1 and loop2
  • Structure:1ICF; p41 fragment interacting with cathepsin L
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #                #                   #     #                          
1ICF_I       3 KCQEEVshipa-------vhpgSFRPKCDE--NGNYLPLQCYGsi--gYCWCVFPn-GTEVPNTRsr---ghHNC 62   human
7507097     52 DCASQRrkalkrk---tdgdarIYIPTCSPknSLLYDKVQCYDvs--iYCWCVDElsGEPKLGSSttr--gkPKC 119  Caenorhabditis elegans
NP_071711   93 KCRLERaqaleqa---kkpqeaVFVPECGE--DGSFTQVQCHTyt--gYCWCVTPd-GKPISGSSvqn--ktPVC 157  house mouse
BAB20274   226 SCDQEHqsaleea--kqpkndnVVIPECAH--GGLYKPVQCHPst--gYCWCVLVdtGRPIPGTStry--eqPKC 292  human
12644045   301 KCEVEQfaat--------rfghSYIPRCHR--DGHYQTVQCQTe---gMCWCVDAq-GREVPGTRqqg--qpPSC 359  house mouse
AAF34909  1005 FYQKLRaslgesngtasllwsgPYMPQCNT--IGGWEPVQCHPgt--gQCWCVDGw-GELIPGSLmarssqmPQC 1074 Norway rat
135838     300 KCEVERfaat--------sfrhPYVPSCHP--DGEYQAAQCQQg---gPCWCVDSr-GQEIPGTRqrg--epPSC 358  cow
AAF34909   301 KCEVEQftat--------sfghPYIPSCHR--DGHYQTVQCQMe---rMCWCVDAq-GIEIPGTRqqg--qpLFC 359  Norway rat
AAL13844   395 NCWMDQsvtleeq--ghggksvLFVPQCLP--DGRYQRIQCYSststsYCWCVNEdtGKSIPGTSvkn--krPQC 463  fruit fly
BAB20274    89 RCVAERkytqeqa---rkefqqVFIPECND--DGTYSQVQCHSyt--gYCWCVTPn-GRPISGTAvah--ktPRC 153  human

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