1MNM,1EGW,1HBX


Conserved Protein Domain Family
MADS
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cd00120: MADS 
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MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.
Links
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Statistics
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PSSM-Id: 238067
Aligned: 91 rows
Threshold Bit Score: 52.5162
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:2 distinct subgroups within MADS-box: SRF-like/Type I and MEF2-like/Type II; 1MNM_B and 1HBX_B belong to Type I and 1C7U_A belongs to Type II
  • Structure:1MNM_B, interaction of the N-terminal and alpha 1 helix with the major and minor grooves of the DNA
    - View structure with Cn3D
  • Citation:PMID 9490409
  • Structure:1EGW_A, interaction of the N-terminal and alpha 1 helix with the major and minor grooves of the DNA
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     ##### #    # #   ## ### ##  ## ##   #                      
1MNM_B     17 ERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVSETGLVYTFSTP 75  baker's yeast
AAB61081    6 TKRKIEIKKRETKEQRAVTCSKRRQTVFSKAADLCLISGANIAVFVTSPSDSSDVVYSF 64  thale cress
BAB55719    4 RARRTGAAYVDDERERDITFFKRRNGLFKCASDLSILTGASVAVVIEDQNRSKFHAVGT 62  rice
NP_176285   4 KKTKIEIKKIINKPAKTVAFTKRREGLFRKASQLCLLSPATQIAILAAPMTSKSHASFY 62  thale cress
NP_176288   4 TKRKIEMKRIEDKNVRAVAFTKRKSGLFHKASELCLLSPGTQIAILATPLSSHSHASFY 62  thale cress
NP_175144   4 VKRKIAIEKIQNKNPRAVSFSKRRKGLYSKASELCLLSDAEIAIIATPVSSNSNAAFYS 62  thale cress
NP_175249  16 TKRKIEIEKRMTKQQRSVACSKRRPTLFSKAADLCLLSGANIAVFVTSPDENSDVVYSF 74  thale cress
NP_196084   4 VKRKISIELIEKKDSRAVAFSKRSRGLYSKASDLCLLSDAQIAIIATPVSSKSNVSFYT 62  thale cress
NP_199753   7 TKRKIAIETIQKRDSLRVTCTKRREGLYSKASQLCLLSDAQIAILATPPSSESNVSFYS 65  thale cress
BAB67993    2 PRAKTPMGLIPFPKKRAATFARRKETVMKMAKELSVLCDAQVAVVVGNPGGGAAEKAAW 60  rice

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