1LMQ,1LMT,1GHL,1A4V,1JUG,1HFY,1HFX,2EQL,1J8X,1IIZ


Conserved Protein Domain Family
LYZ1

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cd00119: LYZ1 (this model, PSSM-Id:238066 is obsolete and has been replaced by 340357)
Click on image for an interactive view with Cn3D
C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have primarily bacteriolytic function; hydrolysis of peptidoglycan of prokaryotic cell walls and transglycosylation. LA is a calcium-binding metalloprotein that is expressed exclusively in the mammary gland during lactation. LA is the regulatory subunit of the enzyme lactose synthase. The association of LA with the catalytic component of lactose synthase, galactosyltransferase, alters the acceptor substrate specificity of this glycosyltransferase, facilitating biosynthesis of lactose.
Statistics
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PSSM-Id: 238066
Aligned: 50 rows
Threshold Bit Score: 139.316
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:lysozyme catalytic site [active site]
Evidence:
  • Comment:hydrolysis of 1,4-beta-linkage between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan of prokaryotic cell walls

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       #                 #                           
1LMQ        1 KVYDRCELARALKasgmdgyagnSLPNWVCLSKWESSYNTQATNRNTd-GSTDYGIFQINSRYWCDDGrtpgakNVCGIR 79  rainbow trout
1GHL_A      2 KVYGRCELAAAMKrmgldnyrgySLGNWVCAAKFESNFNTGATNRNTd-GSTDYGILQINSRWWCNDGrtpgskNLCHIP 80  ring-necked pheasant
2EQL        1 KVFSKCELAHKLKaqemdgfggySLANWVCMAEYESNFNTRAFNGKNanGSSDYGLFQLNNKWWCKDNkrs-ssNACNIM 79  Equus caballus
XP_058378  66 KIYTRCKLAKIFSragldnywgfSLGNWICMAYYESGYNTTAQTVLDd-GSIDYGIFQINSFAWCRRGklk-enNHCHVA 143 human
BAB32128   22 KVYDRCSLARTLQslglagfqgiTLANWVCLAKWESNFNTNTTRFNPedQSTSYGIFQINSRFWCNDGktpgsrNFCRIS 101 house mouse
AAL23948   19 KVFGKCEFAELLKrdyy--lsndDIKNWVCIAEFESSFNTAAINRNRn-RSTDYGIFQINNKYWCGSDyg---kNVCKIP 92  Pacific white shrimp
BAB24499   20 NIIHRCSLAKILYeedldgfegySLPDWLCLAFVESNFNISKVNENVd-GSFDYGIFQINSRYWCNDYqsh-seNFCHVD 97  house mouse
BAB24544   94 KVFSRCELAKEMHdfgldgyrgyNLADWVCLAYYTSGFNTNAVDHEAd-GSTNNGIFQISSRRWCRTLasn-gpNLCRIY 171 house mouse
XP_066926  22 KIYERCELAARLEraglngykgyGVGDWLCMAHYESGFDTAFVDHNPd-GSSEYGIFQLNSAWWCDNGitp-tkNLCHMD 99  human
AAK85299   19 KTLGRCDVYKIFKnegldgfegfSIGNYVCTAYWESRFKTHRVRSAD--TGKDYGIFQINSFKWCDDGtpg-gkNLCKVA 95  zebrafish
Feature 1                                                            
1LMQ       80 CSQLLTDDLTVAIRCAKRVVLDp-------nGIGAWVAWRLhCQNqDLRSYVagC 127 rainbow trout
1GHL_A     81 CSALLSSDITASVNCAKKIVSDg-------nGMNAWVAWRKhCKGtDVNVWIrgC 128 ring-necked pheasant
2EQL       80 CSKLLDENIDDDISCAKRVVRDp-------kGMSAWKAWVKhCKDkDLSEYLasC 127 Equus caballus
XP_058378 144 CSALVTDDLTDAIICAKKIVKEt-------qGMNYWQGWKKhCEGrDLSDWKkdC 191 human
BAB32128  102 CKALLKSNIWSAVLCAKRIVKDp-------qGIYSWAGWIKhCKNkNLKEYIrgC 149 house mouse
AAL23948   93 CSDLMSDDITEALRCAETIRRDterfrgrgkGYSAWVAYNSkCKNrDLDQYMaeC 147 Pacific white shrimp
BAB24499   98 CQELLSPNLISTIHCAKKIVSGp-------gGMKNWVEWKLhCLGrPLSYWMtgC 145 house mouse
BAB24544  172 CTDLLNNDLKDSIVCAMKIVQEp-------lGLGYWEAWRHhCQGrDLSDWVdgC 219 house mouse
XP_066926 100 CHDLLNRHILDDIRCAKQIVSSq-------nGLSAWTSWRLhCSGhDLSEWLkgC 147 human
AAK85299   96 CSDLLNDDLKASVGCAKLIVKMd--------GLKSWETWDSyCNGrKMSRWVkgC 142 zebrafish

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