1CDZ,1L0B,1L0B,1JNX,1KZY,1IMO,1KZY


Conserved Protein Domain Family
BRCT
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cd00027: BRCT (this model, PSSM-Id:237994 is obsolete and has been replaced by 349339)
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Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks.
Links
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Statistics
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PSSM-Id: 237994
Aligned: 144 rows
Threshold Bit Score: 29.2119
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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Dimer interfaceBRCT sequence
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Dimer interface [polypeptide binding site]
Evidence:
  • Citation:PMID 9799248
  • Comment:Residues at the dimer interface include specific salt bridges
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                       #   #  #  #  #                                                 
1CDZ_A       8 GKHFFLYGefp--gdERRKLIRYVTAFNG-ELEDyms---drvQFVITaqewdpsf--------eealmdnpSLAFVRPR 73   human
6015052      3 NLVLCFTGfrk--keELVKLVTLVHHMGG-VIRKecn---skvTHLVAnctqgek----------frvavslGTPIMKPE 66   house mouse
1665785    136 DVTISCTSle---keKREEVHKYVQMMGG-RVYRdln---vsvTHLIAgevgskk----------ylvaanlKKPILLPS 198  human
7496322    706 QFEIIYYRrr----kLKSPFTEWLLPLLN-QLTKtnadalpttTHCIVktdpdgtletd---nidlliwifnGVIIVKES 777  Caenorhabditis e...
7500728    180 DVKISFTGln---ltKKQELYEKIGWMCG-VVGDaly---hetTHLVTekaeqtek---------ykaavnnSIKLMRIG 243  Caenorhabditis e...
7505178    951 KVWIHYNDmmaeageADTDVKEAFVKMFPkNMVTdar----eaTHIILptdekgvlsfdvrgdkemfpyifrETVLMKNS 1026 Caenorhabditis e...
7507992    121 DVTMKLAAev----pNKRELVDLVHYMGG-SVRKdtv----srTNVFIaakveak----------vqsislvGVPTMRAD 181  Caenorhabditis e...
7505176     69 KVWCYVNEldkdetsEYYISRTEFSKLYAgNVVRkve----daTHIVLpenen---------------gsvtKTVVMKSS 129  Caenorhabditis e...
7504429    753 TMSYRIRIda----qLTGITYESFIERYKgNVTDqms----gvTHFIVltdatglfesd---dfgyimciflPTLIMKQQ 821  Caenorhabditis e...
7504456    875 ALKMGSYIna----yNKHGNTALHVAVRK-AHTSdeqm--sttTHCVVktnengilete---sleiffwifnGTIIVKEQ 944  Caenorhabditis e...

Feature 1             
1CDZ_A      74 WIYSCNE 80   human
6015052     67 WIYKAWE 73   house mouse
1665785    199 WIKTLWE 205  human
7496322    778 WMTDCLE 784  Caenorhabditis elegans
7500728    244 WIDDLWE 250  Caenorhabditis elegans
7505178   1027 WMTACLK 1033 Caenorhabditis elegans
7507992    182 WVTECWK 188  Caenorhabditis elegans
7505176    130 WLKASIK 136  Caenorhabditis elegans
7504429    822 WMNDCLK 828  Caenorhabditis elegans
7504456    945 WMSDCLQ 951  Caenorhabditis elegans

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