Conserved Protein Domain Family
alaS
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PRK00252: alaS (this model, PSSM-Id:234701 is obsolete)
alanyl-tRNA synthetase; Reviewed
Links
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Statistics
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PSSM-Id: 234701
Aligned: 968 rows
Threshold Bit Score: 885.199
Created: 9-Dec-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
24216106    3 PKSVSEIREIFLNYFKDKSHNVVPSSSLLPAGDPTLLFTTAGMVQFKPLFTGAVELPYTRATSCQKCLRTTDLEVVGKTE 82  
161506983   3 KLTSSEFRQMFLDFFKDHGHMIMPSASLIPQDDPTLLWINSGVATMKKYFDGSVVPKNHRITSSQKSIRTNDIENVGKTA 82  
191637661   3 KMSSGEIRQMFLDFFKSKGHAVEPSASLIPVDDPTLLWINSGVATLKKYFDGSVVPDNPRITNAQKSIRTNDIENVGKTA 82  
258507762   3 KMSSGEIRQMFLDFFKSKGHAVEPSASLIPVDDPTLLWINSGVATLKKYFDGSVIPDNPRITNAQKSIRTNDIENVGKTA 82  
295692276   3 KLNSSEFRQMFLDFFKDHGHMIMPSASLIPQDDPTLLWINSGVATMKKYFDGSVVPKNHRITSSQKSIRTNDIENVGKTA 82  
301065839   3 KMSSGEIRQMFLDFFKSKGHAVEPSASLIPVDDPTLLWINSGVATLKKYFDGSVVPDNPRITNAQKSIRTNDIENVGKTA 82  
58336754    3 KLNSSEFRQMFLDFFKEHGHMIMPSASLIPQDDPTLLWINSGVATMKKYFDGSVVPKNRRITSSQKSIRTNDIENVGKTA 82  
104774413   1 ---------MFLDFFAEHGHMVMQSASLIPKDDPTLLWINSGVATMKKYFDGSVVPKNRRITSSQKSIRTNDIENVGKTA 71  
116494328   3 KMSSGEIRQMFLDFFKSKGHAVEPSASLIPVDDPTLLWINSGVATLKKYFDGSVVPDNPRITNAQKSIRTNDIENVGKTA 82  
116514511   3 KLNSSEFRQMFLDFFAEHGHMVMQSASLIPKDDPTLLWINSGVATMKKYFDGSVVPKNRRITSSQKSIRTNDIENVGKTA 82  

24216106   83 RHCTFFEMLGNFSFGDYFKEEAIEYALDCSVN--HFGFDKNKIWVTVYTDDDEAEKIWL-SKGIPKERITRLgkKDNFWg 159 
161506983  83 RHQTFFEMLGNFSVGDYFRDEAIPWAWEFLTSpkWLGLPKEKLYCTVYPKDVDSQRVWE-KAGMPADHIVKL--EDNFW- 158 
191637661  83 RHLTFFEMLGNFSVGDYFKKEVIPWAWELLTSpkWFGFDPKRLYVTVYPKDKVTKELWQ-KTGVPDDHIVEA--EDNFW- 158 
258507762  83 RHLTFFEMLGNFSVGDYFKKEVIPWAWELLTSpkWFDFDPKRLYVTVYPKDKVTKELWR-KVGVADDHIVEA--EDNFW- 158 
295692276  83 RHQTFFEMLGNFSVGDYFRDEAIPWAWEFLTSpdWLGLPKEKLYCTVYPKDEDSFNVWV-KAGMPADHIVKL--EDNFW- 158 
301065839  83 RHLTFFEMLGNFSVGDYFKKEVIPWAWELLTSpkWFGFDPKRLYVTVYPKDKVTKELWQ-KTGVPDDHIVEA--EDNFW- 158 
58336754   83 RHQTFFEMLGNFSVGDYFRDEAIPWAWEFLTSpkWLGLPKEKLYCTVYPKDEDSFNVWV-KAGMPADHIVKL--EDNFW- 158 
104774413  72 RHQTLFEMLGNFSVGDYFKEEAIPWAWEFLTSpdWLDLDKDKLYVTVYPKDTEAHRIWHeVVGLPESHIVQL--EDNFW- 148 
116494328  83 RHLTFFEMLGNFSVGDYFKKEVIPWAWELLTSpkWFGFDPKRLYVTVYPKDKVTKELWQ-KTGVPDDHIVEA--EDNFW- 158 
116514511  83 RHQTLFEMLGNFSVGDYFKEEAIPWAWEFLTSpdWLDLDKDKLYVTVYPKDTEAHRIWHeVVGLPESHIVQL--EDNFW- 159 

24216106  160 PAGDsGACGPCSELYLDRGIEKggpncatSGTCKPGCDCDRFLEFWNIVFNQFNQDT-EGNLHPLKQTGIDTGSGLERVA 238 
161506983 159 DIGE-GPCGPDTEIFYDRGQENndv-aedDPENFPGGENARYLEIWNIVFSQYNH-LpNGKYVDQPHKNIDTGMGLERVL 235 
191637661 159 DIGE-GPSGPDSEIFYDRGQQFnnv-aedDPENYPGGENSRYVEIWNIVFSELNH-LpDGRFVEQPHKNIDTGMGLERLV 235 
258507762 159 DIGE-GPSGPDSEIFYDRGQSFnnv-aedDPENYPGGENSRYVEIWNIVFSELNH-LpDGRFVEQPHKNIDTGMGLERLV 235 
295692276 159 DIGE-GPCGPDTEIFYDRGQENndv-aedDPENFPGGENARYLEIWNIVFSQYNH-LpNGKYVDQPHKNIDTGMGLERVL 235 
301065839 159 DIGE-GPSGPDSEIFYDRGQQFnnv-aedDPENYPGGENSRYVEIWNIVFSELNHLP-DGRFVEQPHKNIDTGMGLERLV 235 
58336754  159 DIGE-GPCGPDTEIFYDRGQENndv-aedDPENFPGGENARYLEIWNIVFSQYNH-LpNGKYVDQPHKNIDTGMGLERVL 235 
104774413 149 DIGE-GPCGPDSEIFYDRGQENndv-pedDPENYPGGENARYLEIWNIVFSEFNH-LpDGSYVEQPHKNIDTGMGLERVL 225 
116494328 159 DIGE-GPSGPDSEIFYDRGQQFnnv-aedDPENYPGGENSRYVEIWNIVFSELNH-LpDGRFVEQPHKNIDTGMGLERLV 235 
116514511 160 DIGE-GPCGPDSEIFYDRGQENndv-pedDPENYPGGENARYLEIWNIVFSEFNHLP-DGSYVEQPHKNIDTGMGLERVL 236 

24216106  239 LLLQEVDSVYDTNELRKIISFYEELSGISyedktlseisekknnnqqissqvrnetksiqdsrKTAFRVVTDHIRSVLFS 318 
161506983 236 SILQDAPTNFETDLFLPIIHATEEMTDGKkygen--------------------------kedtTAFKIIADHVRAVSFA 289 
191637661 236 AVIQGTPTIFETDLFMPIIKATEKMSAGKrygvs--------------------------aqddVSFKIIADHARTVTFA 289 
258507762 236 AVIQGTPTIFETDLFMPIIKATEKMSAGKrygan--------------------------aqddVSFKIIADHARTVTFA 289 
295692276 236 SILQDAPTNFETDLFLPIIHATEEMTDDKkygvn--------------------------kedtTAFKIIADHVRAVSFA 289 
301065839 236 AVIQGTPTIFETDLFMPIIKATEKMSAGKrygv--------------------------saqdDVSFKIIADHARTVTFA 289 
58336754  236 SILQDAPTNFETDLFLPIIHATEEMTDGKkygen--------------------------dedtTAFKIIADHVRAVSFA 289 
104774413 226 SILQDAPTNFETDLFLPIIHATEEMSAGKkygan--------------------------kaddISFKIIADHIRAISFA 279 
116494328 236 AVIQGTPTIFETDLFMPIIKATEKMSAGKrygvs--------------------------aqddVSFKIIADHARTVTFA 289 
116514511 237 SILQDAPTNFETDLFLPIIHATEEMSAGKkyga--------------------------nkadDISFKIIADHIRAISFA 290 

24216106  319 IGDGIYPDRTGRGYVIRRLIRRATLFGRKLNFKEPFLYKLVDKVIEIYKARYPELQRNAAAITKTILVEEELFLKTLELG 398 
161506983 290 IADGALPSNSGRGYVLRRLIRRADLHGQRLGIKGAFLYKLVPVVGKIMQSHYPEVMDQRGFIENVIQNEEKRFQATLDTG 369 
191637661 290 IGDGALPSNEGRGYVLRRLIRRAVLNGKKLGIDHDFLYQLVPVVGEIMKSYYPQILANQQFIQKVIESEEARFRQTLDAG 369 
258507762 290 IGDGALPSNEGRGYVLRRLIRRAVLNGKKLGINHDFLYQLVPVVGEIMKSYYPQILANQPFIQKVIESEEARFRQTLDAG 369 
295692276 290 IADGALPSNSGRGYVLRRLIRRADLNGQRLGIKGAFLYKLVPVVGKIMESHYPEVMDQRGFIENVIQNEEERFQSTLDTG 369 
301065839 290 IGDGALPSNEGRGYVLRRLIRRAVLNGKKLGIDHDFLYQLVPVVGEIMKSYYPQILANQQFIQKVIESEEARFRQTLDAG 369 
58336754  290 IADGALPSNSGRGYVLRRLIRRADLNGQRLGIKGAFLYKLVPVVGKIMESHYPEIMDQRGFIENVIQNEEERFQSTLDTG 369 
104774413 280 IGDGALPGNTGRGYVLRRLLRRAALNGRKLGIDGAFLYKLVPVVGDIMKSHYPEVSDQAEFISKVVKNEEDRFGATLEAG 359 
116494328 290 IGDGALPSNEGRGYVLRRLIRRAVLNGKKLGIDHDFLYQLVPVVGEIMKSYYPQILANQQFIQKVIESEEARFRQTLDAG 369 
116514511 291 IGDGALPGNTGRGYVLRRLLRRAALNGRKLGIDGAFLYKLVPVVGDIMKSHYPEVSDQAEFISKVVKNEEDRFGATLEAG 370 

24216106  399 LEKIESLVQKTkaggktIFSGADAFLLYGTYGFPAEMTEEIVAEQGLDFDKKGFQEELEKDRQFSRESWKVNk-vSLMTG 477 
161506983 370 LTLLDDLIDKAkksddkTISGKDAFKMFDTYGFPYELTFESAQDAGLKVDKKGFDAEMQAQKERARKARGDLqsmGRQDV 449 
191637661 370 VTLLNQIIADLkqdgkkEIPGADAFKLFDTYGFPVEMTNEYAQDEGLQVDMAGFKKNMAAQRDRARKARGDRqsmGSQDK 449 
258507762 370 VNLLNQIIAELkqdgkkEISGADAFKLFDTYGFPVEMTNEYAEDEGLKVDMAGFKKNMAAQRDRARKARGDRqsmGSQDT 449 
295692276 370 LTLLDDLIDKAknskdkTISGKDAFKMFDTYGFPYELTFESAQDAGLKVDKKGFDAEMAAQKERARKARGDLqsmGRQDV 449 
301065839 370 VTLLNQIIADLkqdgkkEIPGADAFKLFDTYGFPVEMTNEYAQDEGLQVDMAGFKKNMAAQRDRARKARGDRqsmGSQDK 449 
58336754  370 LTLLDDLIEKAknsddkTISGKDAFKMFDTYGFPYELTFESAQDAGLKVDKKGFDAEMQAQKDRARKARGDLqsmGRQDV 449 
104774413 360 LTLLDDLIDKAensedkTISGKDAFKMFDTYGFPYELTVEAAEDKGLKVDKDGFDAEMEAQKERARKARGNLqsmGSQDE 439 
116494328 370 VTLLNQIIADLkqdgkkEIPGADAFKLFDTYGFPVEMTNEYAQDEGLQVDMAGFKKNMAAQRDRARKARGDRqsmGSQDK 449 
116514511 371 LTLLDDLIDKAensedkTISGKDAFKMFDTYGFPYELTVEAAEDKGLKVDKDGFDAEMEAQKERARKARGNLqsmGSQDE 450 

24216106  478 LNVDk---TEFLGY-SSVSGKGNITHLFynspkssNslSQvdsklqsstpagtgsydskQVSSLkeGQA-GAIVLNKTPF 552 
161506983 450 TLMNikdkSVF-ERdTYEEPHAKLLDIVv------D--DKl-------------------VDKAd-gEH-ATLVFDKTPF 499 
191637661 450 VLMSittpSKFTGWtELDHKHASLQTIVv------N--DQl-------------------QDSVs-eGT-AQLIFDETPF 500 
258507762 450 VLMDittpSKFTGWtELDHKHATLQAIVv------D--DQl-------------------QDEVs-tGQ-AQLIFDETPF 500 
295692276 450 TLMNikdkSVF-ERdTYEEPHAKLVDIVv------D--DKl-------------------VDKAd-gEH-ATLVFDKTPF 499 
301065839 450 VLMSittpSKFTGWtELDHKHASLQTIVv------N--DQ-------------------LQDSVseGT--AQLIFDETPF 500 
58336754  450 TLMNikdkSEF-EYgVYEEPHAKLIDIVv------D--DKl-------------------VDKAn-gEH-ATLVFDKTPF 499 
104774413 440 TLMKikdkSVF-EYgVYEEE-SQLVDIIv------D--DKl-------------------VDKAd-gEK-ATLIFDKTPF 488 
116494328 450 VLMSittpSKFTGWtELDHKHASLQTIVv------N--DQl-------------------QDSVs-eGT-AQLIFDETPF 500 
116514511 451 TLMKik-dKSVFEY-GVYEEESQLVDIIv------D--DK-------------------LVDKAd--gEkATLIFDKTPF 499 

24216106  553 YPEGGGQVGDIGflrq--gknvFKVFDTQKE-NDSIIHFGEVLSGEFIVSQELEAEVEITRRERLKFHHSGTHLLNGALR 629 
161506983 500 YAERGGQVADHGniydqdgelvAKVTDVQHApNNQNLHFVDL-ILPMEKGKEYVLKIDKERREGLRHSHSATHLLHAALR 578 
191637661 501 YAEMGGQVADHGeikaqdgtvlADVSDVQHApNGQNLHTVTV-KGKLETGQQYWLSVDPLRRKKVSLNHTATHLLDQALR 579 
258507762 501 YAEMGGQVADHGvikaqdgtvlAEVTDVQHApNGQNLHTVTV-KSKLTKGQPYWLSVDRLRRQKVSLNHTATHLLDQALR 579 
295692276 500 YAERGGQVADHGkiynqngelvAEVTDVQHApNDQNLHFVDL-ILPVEKGQEYVLKLDKERREGLRHSHSATHLLHAALR 578 
301065839 501 YAEMGGQVADHGeikaqdgtvlADVSDVQHApNGQNLHTVTVKGK-LETGQQYWLSVDPLRRKKVSLNHTATHLLDQALR 579 
58336754  500 YAERGGQVADHGgiynqdgelvAKVTDVQHApNDQNLHFVDL-ILPMEKGQEYVLKIDKERREGLRHSHSATHLLHAALR 578 
104774413 489 YAERGGQVADHGdiydqegnlvARVVDVQHApNDQNLHFVDV-VLPLVKGQTYKLKIDRARREGLRHSHSATHLLHAALR 567 
116494328 501 YAEMGGQVADHGeikaqdgtvlADVSDVQHApNGQNLHTVTV-KGKLETGQQYWLSVDPLRRKKVSLNHTATHLLDQALR 579 
116514511 500 YAERGGQVADHGdiydqegnlvARVVDVQHApNDQNLHFVDVVLP-LVKGQTYKLKIDRARREGLRHSHSATHLLHAALR 578 

24216106  630 TLLGDHVLQKGSIVSPEYLRFDFSHPSSLTSEEIRQIESWVNESIRKNFPVETKELSIEDAKKTGAVATFGEKYGERVRV 709 
161506983 579 QVLGEHTHQAGSLVDPDYLRFDFTAMEPMTPREIKSVEELVNQKIWEAIDVKTTITTPEEGEKMGALALFDGKYGDKVRV 658 
191637661 580 DVLGEHTHQAGSLVEPDYLRFDFTNFGQVTPKQLRQVETIVNQKIWDALPITWKEMPIEEAKKLGAIAMFGDKYGSVVRI 659 
258507762 580 DVLGEHTHQAGSLVEPDYLRFDFTNFGQVTPKQLREVETIVNQKIWDALPITWKEMPIAEAKKLGAIAMFGDKYGDVVRI 659 
295692276 579 QVLGEHTHQAGSLVDPDYLRFDFTAMEPMTKRELKTVEELVNQKIWEAIQVKTTITTPEEGEKMGALALFDSKYGDKVRV 658 
301065839 580 DVLGEHTHQAGSLVEPDYLRFDFTNFGQVTPKQLRQVETIVNQKIWDALPITWKEMPIEEAKKLGAIAMFGDKYGSVVRI 659 
58336754  579 QVLGEHTHQAGSLVDPDYLRFDFTAMEPMTPRELKSVEELVNQKIWDAIQVKTTITTPEEGEKMGALALFDGKYGDKVRV 658 
104774413 568 QVLGEHTHQAGSVVEPDYLRFDFTSLDPITPRELKNVEKIVNEKIWEAIQVKTTETDPETGKKMGALALFDGKYTDKVRV 647 
116494328 580 DVLGEHTHQAGSLVEPDYLRFDFTNFGQVTPKQLRQVETIVNQKIWDALPITWKEMPIEEAKKLGAIAMFGDKYGSVVRI 659 
116514511 579 QVLGEHTHQAGSVVEPDYLRFDFTSLDPITPRELKNVEKIVNEKIWEAIQVKTTETDPETGKKMGALALFDGKYTDKVRV 658 

24216106  710 VQMGdaSIEFCGGTHVSRTGEIGYFFIKKESSPGAGNRRIEGVCGPAVIeTFQNRFSELTESVQNLnlkikselgeegtk 789 
161506983 659 VQMGdfSSEFCGGTHCSNTNQIGIFKIISESAVGAGMRRIEAVTSKKAY-EYLANRSSLLDDIQADvkatk--------- 728 
191637661 660 VKIGdyNTEFDGGTHPTNSSALGLFKITSESGIGAGIRRVEAVTSKEAY-EYLTQQQDWLSETAENlkidq--------- 729 
258507762 660 VSIGdyNKEFDGGTHPTNTNALGLFKITSESGIGAGVRRVEAVTSKEAY-EYLTQQQDWLKETADHlkidq--------- 729 
295692276 659 VQMGdfSSEFCGGTHVDNTNQIGIFKITSESAVGAGMRRIEAVTSKKAY-EYLANRSDLLDDIQEEvkatk--------- 728 
301065839 660 VKIGdyNTEFDGGTHPTNSSALGLFKITSESGIGAGIRRVEAVTSKEAY-EYLTQQQDWLSETAENlkidq--------- 729 
58336754  659 VQMSdfSSEFCGGTHVDNTDQIGIFKITSESAVGAGMRRIEAVTSKKAY-EYLANRSSLLDDIQEVvkatk--------- 728 
104774413 648 VQMDdfSIEFCGGTHCDNTSQIGVFKIISEQAIGAGVRRIEAVTSKLAY-EYLAGRSDILDQIQAQvkatk--------- 717 
116494328 660 VKIGdyNTEFDGGTHPTNSNALGLFKITSESGIGAGIRRVEAVTSKEAY-EYLTQQQDWLSETAENlkidq--------- 729 
116514511 659 VQMDdfSIEFCGGTHCDNTSQIGVFKIISEQAIGAGVRRIEAVTSKLAY-EYLAGRSDILDQIQAQvkatk--------- 728 

24216106  790 ililsfipgpdeireklekegasavsffrdlseniATKIEENTSSFLKIKKNLAErdFENNTSV-----IENVlassVD- 863 
161506983 729 -------------------------------pdniIDKIDSLESDLHDSQKQVEA--LTKQINQakagqIFDD----VKq 771 
191637661 730 -------------------------------vknvPSKVTQLQADLKAEQKTVAG--LQAKLAAqaaagIFDH----PEe 772 
258507762 730 -------------------------------vknvPSKVTQLQADLKTEQKTVAG--LQAKLAAqaaagIFDR----AEt 772 
295692276 729 -------------------------------pdniVDKIDSLESDLHDAQKQVET--LNKKINAakagqIFND----VKq 771 
301065839 730 -------------------------------vknvPSKVTQLQADLKAEQKTVAG--LQAKLAAqaaagIFDH----PEe 772 
58336754  729 -------------------------------peniVDKIDSIENELRDSQKQVEA--LTKKINQakageIFDN----VKq 771 
104774413 718 -------------------------------vdgiQSKIASLQEELRSAEKQNAA--YEAQINAskagkIFDQ----VKt 760 
116494328 730 -------------------------------vknvPSKVTQLQADLKAEQKTVAG--LQAKLAAqaaagIFDH----PEe 772 
116514511 729 -------------------------------vdgiQSKIASLQEELRSAEKQNAA--YEAQINAskagkIFDQ----VKt 771 

24216106  864 -TGIGkIVSAIFEDKDpNSLKGLSDNLKVREknlLVILG-SRnSENASIVITCSSELTLKGIHCGNLIKTACELLGGKGG 941 
161506983 772 aGDLT-VIATVADVNGmNDLRELADNWKSGNksdVLVLAaENd-GKANMIISLGQKALDKGLKAGDLIKKVAPIFGGGGG 849 
191637661 773 vGGLK-LIAKQVQVAGmNELRQLADKWKAKQasdILVLGtEVs-GKANLLVAVNDTANQAGFKAGDLIKAIAPKVGGGGG 850 
258507762 773 vGGFK-LIAKQVQVAGmNELRQLADEWKTKQasdILVLGtEAn-GKANLLVAANANANQAGLKAGDLIKAIAPKVGGGGG 850 
295692276 772 aGDLT-VIAATADVNGmNDLRELADNWKSGNksdVLVLAaENa-GKANMIIALGQKALDKGLKAGNLIKIAAPIFGGGGG 849 
301065839 773 vGGLK-LIAKQVQVAGmNELRQLADKWKAKQasdILVLGtEV-SGKANLLVAVNDTANQAGFKAGDLIKAIAPKVGGGGG 850 
58336754  772 aGDLT-VIAAIADVNGmNDLRELADNWKSGNksdVLVLAaENd-GKANMIISLDQRALDKGLKAGDLIKKAAPLFGGGGG 849 
104774413 761 vGDLT-VIATIADVKGmNDLREIADQWKSEGksdVLILGaKSe-DKANMLISLGQKALDKGLKAGDLIKSVAAIFGGGGG 838 
116494328 773 vGGLK-LIAKQVQVAGmNELRQLADKWKAKQasdILVLGtEVs-GKANLLVAVNDTANQAGFKAGDLIKAIAPKVGGGGG 850 
116514511 772 vGDLT-VIATIADVKGmNDLREIADQWKSEGksdVLILGaKS-EDKANMLISLGQKALDKGLKAGDLIKSVAAIFGGGGG 849 

24216106  942 GRPDMAQGGGKEKQNLESAIAGV 964 
161506983 850 GRPNMAQAGGKRPEGLNDAIKAV 872 
191637661 851 GRPDMAQAGGKNPAGIPAALSEA 873 
258507762 851 GRPDMAQAGGKKPAGIPSALAEA 873 
295692276 850 GRPNMAQAGGKNPAGLNDAIKAV 872 
301065839 851 GRPDMAQAGGKNPAGIPAALSEA 873 
58336754  850 GRPNMAQAGGKKPEGLNDAIKAV 872 
104774413 839 GRPNMAQAGGKNPEGLQDAIDAA 861 
116494328 851 GRPDMAQAGGKNPAGIPAALSEA 873 
116514511 850 GRPNMAQAGGKNPEGLQDAIDAA 872
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