267033 323 VEVVKKRCQEIDypVLEEYDFRNDHRNPDLDidLKPSTQIRPYQEKSLSKMFGNGR--ARSGIIVLPCGAGKTLVGITAA 400 baker's yeast 19553118 1 --------------------------------------MSSNLRAWQRAALDNFLAnkPRDFLAVATPGAGKTTFALRVA 42 Corynebacterium glu... 20091718 1 -------------------MTISNEAVADMEt-VELEP-LREDKKKIFEDILKYFEt-HQRGYIKVPTGWGKTFLSKHIM 58 Methanosarcina acet... 18202016 1 ---MTQSDHRHTr-PSSYGGTVLTQRv-----sQATVEDSRPLRGWQRRAMVKYLAsqPRDFLAVATPGSGKTTFALRVM 71 Mycobacterium leprae 15840623 1 ----------------------MDPHRDLES--RAFAGNWRVYQQQALDAFDADVAagDNRAYLVLPPGAGKTMIGLEAA 56 Mycobacterium tuber... 15840623 1 ----------------------MDPHRDLES--RAFAGNWRVYQQQALDAFDADVAagDNRAYLVLPPGAGKTMIGLEAA 56 Mycobacterium tuber... 15842460 1 MLHFTAATSRFRl-GRERANSVRSDGGWGVl-qPVSATFNPPLRGWQRRALVQYLGtqPRDFLAVATPGSGKTSFALRIA 78 Mycobacterium tuber... 14590902 1 --------------------MNATAEFNRKl-kQRFGFTLYKYQEKVARDIIELLEsrDRFITVSMPTGSGKTILEMLIA 59 Pyrococcus horikoshii 15610054 25 MLHFTAATSRFRl-GRERANSVRSDGGWGVl-qPVSATFNPPLRGWQRRALVQYLGtqPRDFLAVATPGSGKTSFALRIA 102 Mycobacterium tuber... 15898673 1 ---------------------MTFDDLNKLi-rEKLSVETYPYQKYISEEIEKNLDr-KRFIIISMPTGSGKTLIELSVA 57 Sulfolobus solfatar...
267033 401 CTIKKS-----VIVLCTSSVSVMQWR-QQFLQWCTLQp---------ENCAVFTSDNKEMFQt--eSGLVVSTYSMVANT 463 baker's yeast 19553118 43 TELKASrtvdrIIVVVPTEHLKVQWS-QAAARVGLAL----------DPEFKNSG-SINPAYd--gICVTYAQVSMHPF- 107 Corynebacterium glu... 20091718 59 KKYYDDgk-lvLFLVSKNNPLLSQTYyDRKKNQPLFPnsallssehkEDRKELAKTLKALGKgkgkGFVLFASLQTVLGK 137 Methanosarcina acet... 18202016 72 TELLNShaveqVTVVVPTEHLKVQWT-RAAATHGLAL----------DPKFSNTNPRTSPEYh--gVTMTYAQVAAHPT- 137 Mycobacterium leprae 15840623 57 RRLGRR-----SLVLVPNTAVQAQWA-AAWDNSFPSSdrsa--skcgTERGLASAMNVLTYQs--lAVIDAETDSTVRRE 126 Mycobacterium tuber... 15840623 57 RRLGRR-----SLVLVPNTAVQAQWA-AAWDNSFPSSdrsa--skcgTERGLASAMNVLTYQs--lAVIDAETDSTVRRE 126 Mycobacterium tuber... 15842460 79 AELLRYhtveqVTVVVPTEHLKVQWA-HAAAAHGLSL----------DPKFANSNPQTSPEYh--gVMVTYAQVASHPT- 144 Mycobacterium tuber... 14590902 60 EYLLSKgy-erILVLEPTRFLCDQM--HPNWRELMN------------VGKEYEGNCWSFL-----AGYPVIISTPQTAL 119 Pyrococcus horikoshii 15610054 103 AELLRYhtveqVTVVVPTEHLKVQWA-HAAAAHGLSL----------DPKFANSNPQTSPEYh--gVMVTYAQVASHPT- 168 Mycobacterium tuber... 15898673 58 YHLTNKvs--nIIVLEPTRLLCDQMY-HRFWREVFDD----------DVGVEYEGDCESFE-----KGKKIVVSTPFTTA 119 Sulfolobus solfatar...
267033 464 RnrshdsqkVMDFLTGR-----------EWGFIILDEVHVVPAAMFRRVVSTIAAHA-----KLGLTATLV-----RED- 521 baker's yeast 19553118 108 ---------KHYQLTMA-----------RRSLVILDEIHHGGD--AKSWGDGISQAYrdaehRLALTGT-Pf----RSDd 160 Corynebacterium glu... 20091718 138 Qg------aEIKNLILE-----------HTDLAIVDEIHNFINNRGNDFLNELGERTk----ILGMTATPF-----QGVv 191 Methanosarcina acet... 18202016 138 ---------LHRVRTEG-----------RRTLVIFDEIHHGGN--AKAWGDAIREAFsdatrRLALTGT-Pf----RSDd 190 Mycobacterium leprae 15840623 127 VlrnrdqqaLLDLLHPNgravieraatlGPWTLVLDECHHLLATWGALVSALASVLGaq-taLIGLTATPAt----ELTa 201 Mycobacterium tuber... 15840623 127 VlrnrdqqaLLDLLHPNgravieraatlGPWTLVLDECHHLLATWGALVSALASVLGaq-taLIGLTATPAt----ELTa 201 Mycobacterium tuber... 15842460 145 ---------LHRVRTEA-----------RKTLVVFDEIHHGGD--AKTWGDAIREAFgdatrRLALTGT-Pf----RSDd 197 Mycobacterium tuber... 14590902 120 K--------CISNLKN------------KFDGVIIDEVHHAIT--GTYYNELISKLKpk--iVIGFTALLPsekvyDASl 175 Pyrococcus horikoshii 15610054 169 ---------LHRVRTEA-----------RKTLVVFDEIHHGGD--AKTWGDAIREAFgdatrRLALTGT-Pf----RSDd 221 Mycobacterium tuber... 15898673 120 K--------CLD----------------RADAIIVDEVHHAFG--DARYEEVLVNLEpk--fLIGFTALLPsykkyLIDp 171 Sulfolobus solfatar...
267033 522 DKIGDLNFLIG-------PKLYEANWMELSQKGHIANVQCAEVWCP-----------MTAEFYQEYLRETARKR------ 577 baker's yeast 19553118 161 SQIPFVRYQEDdeghlvsKSDHTYGYSEALADGVVRPVVFLAYSG------------EARWRDSAGEEYAARLGeplnae 228 Corynebacterium glu... 20091718 192 GNVKFVDEIAGd-----mREVYAKTLPECILDEELAPLKYTIAESSedif----eifDFEKGLDELDKQDLFLDcstadk 262 Methanosarcina acet... 18202016 191 KPIPFVTYALDadglmhsQADHTYSYAEGLADGVVRPVVFLVYSG------------QARWRNSAGEEHAARLGeplsae 258 Mycobacterium leprae 15840623 202 WQHTLHDELFG-------TADFVIPTPALVREGDLAPYQELVYLTQ-----------PTPEEQAWIGTHRARFAdlmlal 263 Mycobacterium tuber... 15840623 202 WQHTLHDELFG-------TADFVIPTPALVREGDLAPYQELVYLTQ-----------PTPEEQAWIGTHRARFAdlmlal 263 Mycobacterium tuber... 15842460 198 SPIPFVSYQPDadgvlrsQADHTYGYAEALADGVVRPVVFLAYSG------------QARWRDSAGEEYEARLGeplsae 265 Mycobacterium tuber... 14590902 176 SKISETVGELK-------LLHYDFRKLSDLDPKFNPPKALVDIFDSelnekeieiynLLYLGALEADPSIIHFLertfsr 248 Pyrococcus horikoshii 15610054 222 SPIPFVSYQPDadgvlrsQADHTYGYAEALADGVVRPVVFLAYSG------------QARWRDSAGEEYEARLGeplsae 289 Mycobacterium tuber... 15898673 172 -RLIKLLGQPE-------YLAYDFKSLTKIDPSFKLPKAIADIFDSefnnledsvyeAFFKGLIKGNKETVKFLeltfyt 243 Sulfolobus solfatar...
267033 578 ------------------------------------MLLYIMNPTKFQACQFLIQYHEr-RGDKIIVFSDNVYALQEYAL 620 baker's yeast 19553118 229 qtakaw-------------------rtaldpkgdwiPAVLSAAHTRLMQLRQNIP------DAGGLVIASDTKTARAYAK 283 Corynebacterium glu... 20091718 263 lkkvvrrtqlakdvydsmvkrknaktlvfcapvrkrVYGAGADREEINAFHAKLTASVfnGEISASKLGKDSDPVLPLDF 342 Methanosarcina acet... 18202016 259 qtaraw-------------------rtaldpsgewmPAVISAADQRLRQLRTHVP------DAGGMIIASDQTAARAYAN 313 Mycobacterium leprae 15840623 264 idqkvgsmslaawlhtrivdratregnqiawstferAEPDLACSGLRFAYDGLIPLPDgvRLREQHRIAPDAQDWVNVLT 343 Mycobacterium tuber... 15840623 264 idqkvgsmslaawlhtrivdratregnqiawstferAEPDLACSGLRFAYDGLIPLPDgvRLREQHRIAPDAQDWVNVLT 343 Mycobacterium tuber... 15842460 266 qtaraw-------------------rtaldpegewmPAVITAADRRLRQLRAHVP------DAGGMIIASDRTTARAYAR 320 Mycobacterium tuber... 14590902 249 ygkkalcesffrvv---ekggigespqtyeiiefcrDKDYSHKARTLVDVLTIYNPELnpKLKPIIVFTSRKIAAYEFKD 325 Pyrococcus horikoshii 15610054 290 qtaraw-------------------rtaldpegewmPAVITAADRRLRQLRAHVP------DAGGMIIASDRTTARAYAR 344 Mycobacterium tuber... 15898673 244 ygkeafcesyr--------rligkveespyidsicdSKDLSHKARALKSVLNIYRv---dEFKPVLIFTSRKSTAYEFER 312 Sulfolobus solfatar...
267033 621 KMGKP---------FIYGSTPQQERMNILQNFQYNDq---INTIFLSKVGDTSIDLPEATCLIQISShYGSRRQEAQRLG 688 baker's yeast 19553118 284 ILGTLss-----tpVAVILSDEAGASERIDEFSAST----DEWMVAVRMVSEGVDVPRLAVGVYATS-ASTPLFFAQAIG 353 Corynebacterium glu... 20091718 343 DNYTPdgkf-rdaaFITSELPKDEQSALLAAFRDTKk--pPYVLCTVGMLIEGFDFPGLETLILLRP-TLSMRLFEQQVG 418 Methanosarcina acet... 18202016 314 LLAQMts-----etPTLVLSDDPGSSARITEFAKNT----SQWLIAVRMVSEGVDIPRLSVGIYATS-ASTPLFFAQAIG 383 Mycobacterium leprae 15840623 344 DFSVG---------HLQQSADPRDAHALTAIKRVLPglgyRLTSRGVRVATSPVDRLCALSESKIAAtAHILDTEDAVLG 414 Mycobacterium tuber... 15840623 344 DFSVG---------HLQQSADPRDAHALTAIKRVLPglgyRLTSRGVRVATSPVDRLCALSESKIAAtAHILDTEDAVLG 414 Mycobacterium tuber... 15842460 321 LLTTMta-----eePTVVLSDDPGSSARITEFAQGT----GRWLVAVRMVSEGVDVPRLSVGVYATN-ASTPLFFAQAIG 390 Mycobacterium tuber... 14590902 326 AVVRKlgipsykveVLTSDLSKEERKNLILRAKRGD----IDIIISTLVGEEGVDIPEAGVLIMTDV-PKSALRFYQRLG 400 Pyrococcus horikoshii 15610054 345 LLTTMta-----eePTVVLSDDPGSSARITEFAQGT----SRWLVAVRMVSEGVDVPRLSVGVYATN-ASTPLFFAQAIG 414 Mycobacterium tuber... 15898673 313 AIS-Dlgk----vkVITGDSPRYERLKVVQNLRKGE----IDVLISTIVGEEGIDIPEAKLLIMTDV-PQSPLRFYQRLG 382 Sulfolobus solfatar...
267033 689 RILRAk--RRNDEGFNAFFYSLVSKDTQEMYYSTKRQA------------------------------------------ 724 baker's yeast 19553118 354 RFVR----SRMPGETASVFLPSVPVLLELAEKLEVSRDhvlgkphrpkegwddellqean-------------------- 409 Corynebacterium glu... 20091718 419 RVTRLs-pVSGKGKGHIFEISDSIDSLYQRFGEGVFNGekvdqvqmlqpeirleelfsegdaalaieegkie-iskvdls 496 Methanosarcina acet... 18202016 384 RFVR----SRHPGETASIFVPSVPNLLQLASELETQRNhvlgkphrestdnplggnpatm-------------------- 439 Mycobacterium leprae 15840623 415 ARLRAlvlCDFESMTGALPTSLKGAPVSEQSGSAQLVAamlaasdhrrrtplhallvtgqtfacpaa----------ied 484 Mycobacterium tuber... 15840623 415 ARLRAlvlCDFESMTGALPTSLKGAPVSEQSGSAQLVAamlaasdhrrrtplhallvtgqtfacpaa----------ied 484 Mycobacterium tuber... 15842460 391 RFVR----SRRPGETASIFVPSVPNLLQLASALEVQRNhvlgrphresahdpldgdpatr-------------------- 446 Mycobacterium tuber... 14590902 401 RLIR----ISSPMDTKVFVITMTPKTKEYEDLSEAVRNlywegvdvsyilinleeklttqrlidhiktlmkrlnskwvsy 476 Pyrococcus horikoshii 15610054 415 RFVR----SRRPGETASIFVPSVPNLLQLASALEVQRNhvlgrphresahdpldgdpatr-------------------- 470 Mycobacterium tuber... 15898673 383 RLIRGkekEEGESAIKYLVVTLTPKTSEYDNLDEALRNlylegvdvsyliekredkgpvarvidiinksggrvlinqidd 462 Sulfolobus solfatar...
267033 725 --------------------------FLVDQGYAFKVITHLHGMENIPNLAYASPRERRELL 760 baker's yeast 19553118 410 ----rkesepddmpkyeslgaeaeldSLIYDGST--YGTGTFSGSAEEADYLGLPGLLDAEQ 465 Corynebacterium glutamicum ATCC 13032 20091718 497 nlkkgrgkgrgrknaqavevpvrlppTALRAKYFSRLLAITEEKDVGAFEREKRELMRGALR 558 Methanosarcina acetivorans C2A 18202016 440 ----tqteqddtekyftaigadaeldQIIFDGSS--FGTATPAGSEEEAYYLGIPGLLDADQ 495 Mycobacterium leprae 15840623 485 dliafcaergalvtaepldahpslrvMRGTGGFTPRTWVALATEYFLAGRARVLVGTRSLLG 546 Mycobacterium tuberculosis CDC1551 15840623 485 dliafcaergalvtaepldahpslrvMRGTGGFTPRTWVALATEYFLAGRARVLVGTRSLLG 546 Mycobacterium tuberculosis CDC1551 15842460 447 ----tqterggaergftalgadaeldQVIFDGSS--FGTATPTGSDEEADYLGIPGLLDAEQ 502 Mycobacterium tuberculosis CDC1551 14590902 477 mlltqrnelkdpieyymqvlksneefrsalterfgelseeefdkwtfmvvttfflrawddki 538 Pyrococcus horikoshii 15610054 471 ----tqterggaergftalgadaeldQVIFDGSS--FGTATPTGSDEEADYLGIPGLLDAEQ 526 Mycobacterium tuberculosis H37Rv 15898673 463 tkkrtlsllsllesnesrshideyvdRTLRDGKALYYYDEEMMGKIISQVLLG--SYCNIGF 522 Sulfolobus solfataricus
Jiyao W et al.(2023). "The conserved domain database in 2023.",