2J0U


Conserved Protein Domain Family
Btz
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smart01044: Btz 
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CASC3/Barentsz eIF4AIII binding
This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.
Links
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Statistics
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PSSM-Id: 214991
Aligned: 14 rows
Threshold Bit Score: 84.0367
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2J0U_T         10 RQSGDGQESTEP--VE--NKVGKKGPKHLDDDEDR----K----NPAYIPRKGLFFEHDLRgqTQEEEV----------- 66   human
NP_001012670  125 RQSGDGQESTEP--EE--NKTSKKSQKQLDDDEDR----K----NPAYIPRKGLFFEHDLR--GHVNDEe---------- 180  western clawe...
CAF90477      152 RQSGDGQESTDD--PE--TKAAGKAGQKLDDDEDR----K----NPAYIPRKGLFFEHDVR--GHAQEEerytawahqed 217  spotted green...
XP_317919     147 RQSGDGQEQDAE------------SRRKVDDDEDR----S----NPQYIPKKGTFYEHDDRtaEDDLD------------ 194  Anopheles gam...
XP_001656011   39 geddeedddgsdddVI--EEQETDSKRKVDDDEDR----S----NPQYIPKKGTFYEHDDRtlEDEEDGk---------- 98   yellow fever ...
XP_755021     144 SGSLTGRTPSAPptEA--KRETFAERKRREHERYA----KerdeNPAFVPTRGRFFLHDKRstEPGPNGh---------- 207  Aspergillus f...
NP_493346      55 RSGGDSEEKEDE--AAedGPEDGEEKSNLDDDQNV----E----NPAYIPKTGRFYMHDDNrrGDVNNSq---------- 114  nematode
AAD55481      108 AGNGTDDSAATD---------------LVDGEEQK----Kk---EPFAVPTAGAFYMHDDRfqELDAASn---------- 155  thale cress
XP_003050735  140 VSSASARPQAAP-----------ANRRRQEHEDYKrrrdE----DPAFVPNRGAFFMHDHRhaGPAANGf---------- 194  Nectria haema...
NP_172980      78 SGGGIDNDKSGV--V----KEAGDMNGEEENEKEK----L-----QAAVPTGGAFYMHDDRfqEMSAGGn---------- 132  thale cress

2J0U_T         67 -------------RPK---------------------GRQ-RKLW--------------------KDEGRWEHDKFREDE 91   human
NP_001012670  181 ------------vRPK---------------------GRHpRKLW--------------------KDEGRWEHDRFREDE 207  western clawe...
CAF90477      218 aatppalshlsvrRPK---------------------TRN-RKLW--------------------KDEGRWEHDRFREEE 255  spotted green...
XP_317919     195 -------------------------------------DSGgAKKWq-------------------ASADRWTHDRFDESE 218  Anopheles gam...
XP_001656011   99 -------------AGDesvnnddpagpggdrkvdknaVSKaTKKWq-------------------ASADRWTHDRFDESE 146  yellow fever ...
XP_755021     208 -------------RPF---------------------SKSkSRPYglivdgnv-----rrhskpdASEGQWTHDLHETVA 248  Aspergillus f...
NP_493346     115 ------------vQDD---------------------DSDdRRNLkk-----------------sRADCDWKHDRFDEKF 144  nematode
AAD55481      156 -------------RRM----------------------RGgRRLWq------------------sRDERKWGHDKFEEMN 182  thale cress
XP_003050735  195 -------------RPF---------------------GRGrGRGGrggiggpyapinqlhhpgdpTTNSPWTHDMHETVV 240  Nectria haema...
NP_172980     133 -------------RRM---------------------RGGrRQWGs-------------------GEERKWGHDKFEEMN 159  thale cress

2J0U_T         92 -QAPKS-RQELIALYGYDIRSAH 112  human
NP_001012670  208 -QAPKS-REELISIYGYDIRSSK 228  western clawed frog
CAF90477      256 -QAPKS-REELIAIYGYDIRNGS 276  spotted green pufferfish
XP_317919     219 -QAPKS-QAELVFAYGYDIRSED 239  Anopheles gambiae str. PEST
XP_001656011  147 -QAPKS-RAELVSAYGYDIRSED 167  yellow fever mosquito
XP_755021     249 gDEPTN-KPSAVPESMSDFAPKP 270  Aspergillus fumigatus Af293
NP_493346     145 -QRPKT-KKQIVTKYGFDIRHKD 165  nematode
AAD55481      183 -TQKQQ-YDrrtsrgrgrgrgqg 203  thale cress
XP_003050735  241 -EPPPPaRPRHMIVDDEGPANGN 262  Nectria haematococca mpVI 77-13-4
NP_172980     160 -TGEKH-SDQRMSrgrfrghgrg 180  thale cress
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