2D8K,2NSQ,2CHD,1RH8,2ENP,1V27,3KWT


Conserved Protein Domain Family
C2

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smart00239: C2 
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Protein kinase C conserved region 2 (CalB)
Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). Some do not appear to contain Ca2+-binding sites. Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. Unusual occurrence in perforin. Synaptotagmin and PLC C2s are permuted in sequence with respect to N- and C-terminal beta strands. SMART detects C2 domains using one or both of two profiles.
Statistics
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PSSM-Id: 214577
Aligned: 245 rows
Threshold Bit Score: 34.0002
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2D8K_A     27 TLTVKIMKAQELPAKDfs---------gTSDPFVKIYLLPdk----kHKLETKVKRKNl--NPHWNE--TFLFEGFPYe- 88   human
AAA27771   18 CEAVDLKPTDFSLRLQkgstk--ekasqMIEPYVNIDVDEv------YIAKTTTKPKSvkpQWVWNE--DFTSEVHN--- 84   California sea hare
AAB84189   13 CEAVSLKPTAWSLRHAvgpr----pqtfLLDPYIALNVDDs------RIGQTATKQKTn--SPAWHD--EFVTDVCN--- 75   house mouse
CAA21413  382 LVGDLYMGVHGLEGLEqa-----------nDLYICVEVDSygh---yfrKATTKKICRs-qTPLWNE--SFMLELEGSqn 444  fruit fly
CAA72926   11 FMKIRILEALDLNKTNvksqfvtsmkvsSLDPYLQAYVDDq-----vIAKTSKKTATY---CPVWEE--DFSIDLHK--- 77   Hydra vulgaris
AAB62532  348 ALRIRILCATYVNVNIr----------dIDKIYVRTGIYHgge-plcDNVNTQRVPCS---NPRWNEwlSYDMYIPDLpr 413  Avian sarcoma vir...
CAA73557    9 FLRIKILQATSLRGN-------------ASDPHLAVNIKEsirtpggKDVQVVQKKDTf--HPEWGK--CFDSHLND--- 68   Sycon raphanus
1107276A  230 FLNVIVHSATGFKQS--------------SNLYCTLEVDSfgy--fvNKAKTRVYRDTa--EPNWNE--EFEIELEG--- 286  human
BAE26670   17 GEAVGLQPTRWSLRHSlfkk-----ghqLLDPYLTVSVDQv------RVGQTSTKQKTn--KPTYNE--EFCANVTD--- 78   house mouse
AAA18259   12 LEARQLRPTEWSRRFRqdea-----ataAIDSYVNVDWDEy------HIGKTQVRPKTn--EPRWNE--EFTASGVHQ-- 74   nematode
2D8K_A     89 KvvqRILYLQVLDYDRFs----------rNDPIGEVSIP-LNKVDLTQMQTFW 130  human
AAA27771   85 G---QNVNLTVFHDAAi-----------pPDEFVANCTI-PFDDVKGKSDFWI 122  California sea hare
AAB84189   76 G---RKIELAVFHDAPi-----------gYDDFVANCTI-QFEELLQNGSRHF 113  house mouse
CAA21413  445 V---RILLYEAKERP--------------LLKAKHILKVgVKSACIREVERRG 480  fruit fly
CAA72926   78 A---KMLSLTVFHSSIVg----------sDSFVANSSVL-IQDIIDEGQSDLW 116  Hydra vulgaris
AAB62532  414 A---ARLCLSICSVKGRkgak----eehcPLAWGNIN---MFDYTDTLVSGKM 456  Avian sarcoma virus 16
CAA73557   69 G---RRMQVMVTDIVGDgvm--------esTQLGEVTVL-LASIADQCRSQGS 109  Sycon raphanus
1107276A  287 S---QTLRILCYEKCYNktkipkedgestDRLMGKGQVQ-LDPQALQDRDWQR 335  human
BAE26670   79 G---GHLELAVFHETPl-----------gYDHFVANCTL-QFQELLRTAGTSD 116  house mouse
AAA18259   75 G---KAIGFSVFHSCVm-----------pPDDFVANTRI-AFDQLKIGSANDI 112  nematode
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