1Q47


Conserved Protein Domain Family
Sema_3
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cd11239: Sema_3 
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The Sema domain, a protein interacting module, of class 3 semaphorins
Class 3 semaphorins (Sema3s) are secreted regulator molecules involved in the development of the nervous system, vasculogenesis, angiogenesis,and tumorigenesis. There are 7 distinct subfamilies named Sema3A to 3G. Sema3s function as repellent signals during axon guidance by repelling neurons away from the source of Sema3s. However, Sema3s that are secreted by tumor cells play an inhibitory role in tumor growth and angiogenesis (specifically Sema3B and Sema3F). Sema3s functions by forming complexes with neuropilins and A-type plexins, where neuropilins serve as the ligand binding moiety and the plexins function as signal transduction component. Sema3s primarily inhibit the cell motility and migration of tumor and endothelial cells by inducing collapse of the actin cytoskeleton via neuropilins and plexins. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.
Links
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Statistics
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PSSM-Id: 200500
Aligned: 10 rows
Threshold Bit Score: 887.86
Created: 6-Apr-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:1Q47; Mouse Semaphorin 3A dimer interface, contacts at 4A distance.
    - View structure with Cn3D
  • Comment:Semaphorin/plexin signaling is dependent on the formation of a 2:2 heterotetramer that is composed of two plexin molecules bound to a semaphorin homodimer. Monomeric semaphorin binds plexin but does not trigger signaling.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
1Q47_A        23 FNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFNLVNIK-DFQKIVWPVSYTRRDECKWAGKDilkECANFIKVLEAYNQ 101 house mouse
O15041        49 FHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISdGYKEIHWPSTALKMEECIMKGKDa-gECANYVRVLHHYNR 127 human
O42236        45 HRISHSPLDYRILLMDEDQDRIYVGSKDHILSLNINNISqDPLSIFWPASANKVEECKMAGKDpthGCGNFVRVIQSYNR 124 chicken
XP_003217662  89 TYELERSCCYDSLLLDEERGRLFVGGKNYLASLSLDNISkQDKKIYWPAPVEWREECNWAGKDinaECMNFVKILHLYNR 168 green anole
NP_689967     61 FLGSSEGLDFQTLLLDEERGRLLLGAKDHIFLLSLVDLNkNFKKIYWPAAKERVELCKLAGKDantECANFIRVLQPYNK 140 human
XP_003227353  58 FLGHRGILDFRSLYLDEYRDRLFIGGKDTLYSLRLDQTNmDAKEIYWPPLPGQKEECFRKGKDpvtECANFVRVFYPLNR 137 green anole
XP_003210066  48 FNFLLNSSDYRILLKDEDHDRMYVGSKDYVLSLDLHDINrEPLIIHWPASQQRIEECILSGKNsngECGNFIRLIQPWNR 127 turkey
CAK11160      39 VSLSMPAGDLNSLLPDEDGRRLYIGMKDHLLSTSLDDITqNPRKIYWPANPDRIQDCTMAGKTlemDCANFLRVLERYNQ 118 zebrafish
XP_687092     48 FWDGGEGGAYQALLLDEDRGWLLVGGRDHIYMLNSDSLTqPSRKIHWPAGQEHIERCKYAGKNlsmDCANYVRLLQPFNK 127 zebrafish
XP_003217681 153 LLDSDNDLVFQSLLLDEKKAWLMAGAKDHVFLLNLDNPNtKPQKIFWPAPREQREHCRLAGKNpetECANFIRFLQRFNS 232 green anole

Feature 1                                                                                        
1Q47_A       102 THLYACGTGAFHPICTYIEVGhhpednif---klqdshfENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFR 178 house mouse
O15041       128 THLLTCGTGAFDPVCAFIRVGyhledplf---hlesprsERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFR 204 human
O42236       125 THLYVCGSGAFSPVCVYVNRGrrseeqi----fkidskcESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFR 200 chicken
XP_003217662 169 THLYACGTGAFHPICGFVEVGqrvedavf---kldfkslEDGKGKSPYDPRHMAASVFAGEELYSGVATDLMGRDFTIFR 245 green anole
NP_689967    141 THIYVCGTGAFHPICGYIDLGvykediif---kldthnlESGRLKCPFDPQQPFASVMTDEYLYSGTASDFLGKDTAFTR 217 human
XP_003227353 138 THLLACGTGAFHPICALIYVGprgehvf----sldpttiESGRGRCPHEPNRPFASTFVGGDLYTGLTADFLGRDSVIFR 213 green anole
XP_003210066 128 THLYVCGTGAYNPICAFINRGrkaqdyif---ylepdklESGKGKCSYDPKVDTVSALINEELYAGVYIDFMGTDAAIFR 204 turkey
CAK11160     119 THLYACGTGAFNPRCAFIPTNlflraeeq---tlqdedtESGRGKCPFDPHQRTATAIIDGELYAGISSDFLSHDTAFIR 195 zebrafish
XP_687092    128 THVYVCGTGAFHPQCTYIDLGhnlekptf---qllshvgESGRGKCPFSPQEPFTARLTDGELYAGTAVDFMGTNAAIFR 204 zebrafish
XP_003217681 233 SHVFACGTGSYQPICAFIHIKtgaeepglptmqlvqysiGSGRGKCPYNPYEPFAGLLTDGEFYSGTSIDFMGSSAAFFR 312 green anole

Feature 1                                                            ##  #  ###                  
1Q47_A       179 TLghh---hpIRTEQHDSRWLNDPRFISAHLIPESDNPEDDKVYFFFRENAIDGe-HSGKATHARIGQICKNDFGGHRSL 254 house mouse
O15041       205 SMgrl---ahIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKALEAe-NNAHAIYTRVGRLCVNDVGGQRIL 280 human
O42236       201 SLtkr---naVRTDQHNSKWLSEPIFVDAHVIPDGTDPNDAKIYFFFKERLTDNs-GSTKQIHSMIARICPNDTGGQRSL 276 chicken
XP_003217662 246 SLgsr---psIRTEQHDSRWLNEPKFVDVFWIPESENPDDDKIFFFFRETAVEGsqGLGKQTFARIGQICRNDMGGQRSL 322 green anole
NP_689967    218 SLgpthdhhyIRTDISEHYWLNGAKFIGTFFIPDTYNPDDDKIYFFFRESSQEGs-TSDKTILSRVGRVCKNDVGGQRSL 296 human
XP_003227353 214 TMgh----rsSLRTEMDQRLLNAPKFVAAYLIPDNDDRDNDKVYFFFTEKAAESe-SKGRAIFSRVGRICANDAGGQRVL 288 green anole
XP_003210066 205 TMgkq---taMRTDQYNSRWLNDPAFVRAQLIPDSSERNDDKLYFFFREKSADA--PLSPGVYSRIGRICLNDDGGHCCL 279 turkey
CAK11160     196 SLger---hvIRTEQYDSTWLQGAEFVHVTAMSESDNEEDDKVYVFFTERAQEAegAAGKVLYSRVARVCKNDIGGQRSL 272 zebrafish
XP_687092    205 TSvhsnnqhyIRTEAYQDHWLNEPEFVGSYSIPDTHSLDDDKVYFFFKETAVESn-QLDKRIYSRVARVCKNDIGGKRSL 283 zebrafish
XP_003217681 313 TQldrvdqnyIRTEQNQDYWLKEPVFVGAYAIPDTYNHDDDKVYFFFRETAVEAgqWEKRRIYARVARVCKNDVGGKHSL 392 green anole

Feature 1                       #  ## # #   #                      ########                      
1Q47_A       255 VNKWTTFLKARLICSVPGPNgIDTHFDELQDVFLMnSKDPKNPIVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHr 334 house mouse
O15041       281 VNKWSTFLKARLVCSVPGMNgIDTYFDELEDVFLLpTRDHKNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHk 360 human
O42236       277 VNKWTTFLKARLVCSVMDEDgTETYFDELEDVFLLeTDNPRTTLVYGIFTTSSSIFKGSAVCVYHLSDIQTVFNGPFAHk 356 chicken
XP_003217662 323 VNKWTTFLKARLVCAVQGSDgSDTYFDQLRDVFLLpTREKRNPLLYAVFTTSSTVFKGSAVCVYHMNDIRRAFLGPFAHk 402 green anole
NP_689967    297 INKWTTFLKARLICSIPGSDgADTYFDELQDIYLLpTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHk 376 human
XP_003227353 289 VNKWSTFNKARLVCSVPGPDgIDTYFDELEDVFLLrTKDGKSPEIYALFSTISNVFQGFAICVYRMADIWEVFNGPFAHk 368 green anole
XP_003210066 280 VNKWSTFLKARLVCSVPGPDgIETHFDELQDVFIQqTQDTKNPVIYAVFSASGSVFKGSAVCVYSMADIRMVFNGPFAHk 359 turkey
CAK11160     273 VNKWSTFQKARIVCSVPGPDgIQTHFDKLQDIFIQhGRDKKNPLVYGLFTTTSNVLNGSAVCVYRMQDIIRAFKGNFLHr 352 zebrafish
XP_687092    284 INRWSTFLKARLVCTVPGPGgMDTHFDELEDIFLLeTKDPQNPVIYGVFSTSSSVFRGSAVCVYSMASIRAAFNGPFAHk 363 zebrafish
XP_003217681 393 INRWSTFLKARLVCSIPSLHgTETHFDQLEDIFLLrIRNIQDPLIYGLFTVSSGIFNGSAVCVYSMAAIRAAFNGPFAHk 472 green anole

Feature 1           ####                                               #              #          
1Q47_A       335 dgpNYQWVPYQGRVPYPRPGTCPSktfg----gfdsTKDLPDDVITFARSHPAMYNPVFPINNRPIMIKTDVNYQFTQIV 410 house mouse
O15041       361 egpEYHWSVYEGKVPYPRPGSCASkvngg---rygtTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIA 437 human
O42236       357 egpNHQLIPYQGRIPYPRPGTCPGgaftp---nmrtTKEFPDDVVTFIRNHPLMYNPIYPIHKRPLIIRIGTDYKYTKIA 433 chicken
XP_003217662 403 egpNYQWVSFQGRVPYPRPGMCPSktfg----tfssTKDFPDDVIQFARNHPLMYNPVLPHGQKPVFLQTNVGYSFTRIA 478 green anole
NP_689967    377 esaDHRWVQYDGRIPYPRPGTCPSktydp---liksTRDFPDDVISFIKRHSVMYKSVYPVAGGPTFKRINVDYRLTQIV 453 human
XP_003227353 369 dgpDHQWSAYEGKVPYPRPGVCPSkttnqpsrqyssTKDYPDEVLHFARAHPLMSRSVYPLHRRPVLVKTNLQHHLRQIV 448 green anole
XP_003210066 360 egpNYQWMPYTGKMPYPRPGTCPGgtftp---smksTKDYPDEVINFMRSHPLMYHAVYPAHRQPLVVRTNVNYRFTTIA 436 turkey
CAK11160     353 eghQYKLTEYTGRVPYPRPGTCPSstyg----gfrsTREYPDDVIFFSRTHPLMQEVVRPLGGQPLLIRVGVPYKLTRLL 428 zebrafish
XP_687092    364 espDYRWMEYKGKIPYPRPGTCPSetyda---lyksTRDFPDDVVSFMRAHQLMWEPVVPIHRRPVFTRINTPYRLKKLV 440 zebrafish
XP_003217681 473 eglEYQWVEYKGKIPYPRPGTCPSetydp---llqsTKDFPDEVISFMRTHHLMWDPIYPLQGKPILMRANVPFQIHQLL 549 green anole

Feature 1                                                                                        
1Q47_A       411 VDRVDAEDGQYDVMFIGTDVGTVLKVVSVPKEtwhdlEEVLLEEMTVFrepTTISAMELSTKQQQLYIGStaGVAQLPLH 490 house mouse
O15041       438 VDRVEAEDGQYDVLFIGTDNGIVLKVITIYNQemesmEEVILEELQIFkdpVPIISMEISSKRQQLYIGSasAVAQVRFH 517 human
O42236       434 VDRVNAADGRCHVLFLGTDQGTVQKVVVLPTNfs-asGELILEELEVFqsnSPITTMKISSKKQQLYVSSeeGVTQVPLH 512 chicken
XP_003217662 479 VDRVAAADGHYDVLFIGTDVGTVLKVVSVPKEtwqnmEELLLEELQVFkdpTPVTSIQISSKRQQLYVGSrtAISQLPLH 558 green anole
NP_689967    454 VDHVIAEDGQYDVMFLGTDIGTVLKVVSISKEkw-nmEEVVLEELQIFkhsSIILNMELSLKQQQLYIGSrdGLVQLSLH 532 human
XP_003227353 449 VDRVEAEDGQYDVMFIGTDSGSILKVISLQRGnfaaaEEVILEELQVFkapVPITEMEISVKRQMLYVGSrvGVAQVKLH 528 green anole
XP_003210066 437 VDQVDAADGRYEVLFLGTDRGTVQKVIVLPRDdm-etEELMLEEIEVFkvpAPIKVMTISSKRQQLYVSSavGVTHLALH 515 turkey
CAK11160     429 VDRVEAVDGQHDVMFIGTDSGLVLKVLHFPKAnr-qnQEVTLEQLQVFkhkSAITAMTLSKKKQWLFAGSaeGVVQLGLF 507 zebrafish
XP_687092    441 VDRVDAEDGQYDVLHLGTDDGRVLKVVSVPKEnw-eiEEIILEELNVFktqTPILSMELSTKRQVLFISSdeNVVQLPVQ 519 zebrafish
XP_003217681 550 VDRVESEAGHVDVLFLGTDDGKVLKVRVASKEgq-elQEISLEEISISkkhLLILDMQLSLKRQEVFVSSsnGVVQLSLH 628 green anole

Feature 1          
1Q47_A       491 RC 492 house mouse
O15041       518 HC 519 human
O42236       513 RC 514 chicken
XP_003217662 559 RC 560 green anole
NP_689967    533 RC 534 human
XP_003227353 529 HC 530 green anole
XP_003210066 516 RC 517 turkey
CAK11160     508 QC 509 zebrafish
XP_687092    520 RC 521 zebrafish
XP_003217681 629 RC 630 green anole

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