2NUT,1M2O


Conserved Protein Domain Family
Sec23_C
?
cd11287: Sec23_C 
Click on image for an interactive view with Cn3D
C-terminal Actin depolymerization factor-homology domain of Sec23
The C-terminal domain of the Sec23 subunit of the coat protein complex II (COPII) is distantly related to gelsolin-like repeats and the actin depolymerizing domains found in cofilin and similar proteins. Sec23 forms a tight complex with Sec24. The cytoplasmic Sec23/24 complex is recruited together with Sar1-GTP and Sec13/31 to induce coat polymerization and membrane deformation in the forming of COPII-coated endoplasmic reticulum vesicles. The function of the Sec23 C-terminal domain is unclear.
Links
?
Statistics
?
PSSM-Id: 200443
Aligned: 14 rows
Threshold Bit Score: 201.833
Created: 27-Aug-2009
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: catalytic residue [active site], 1 residue position
Conserved feature residue pattern:RClick to see conserved feature residue pattern help
Evidence:
  • Comment:Sec23 contributes a catalytic Arg residue to the Sar1 active site, Ser 719 and Phe 723 stabilize the productive configuration.
  • Structure:11M2O: Sec23-Sar1 binds a non-hydrolyzable GTP analogue (GppNHp), contacts at 4A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
2NUT_A    614 QDLTQSLIMIQPILYAYSFS-GPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHLLQAP 692 human
1M2O_A    616 EDTTNSLIMIQPTLTSFSME-DDPQPVLLDSISVKPNTILLLDTFFFILIYHGEQIAQWRKAGYQDDPQYADFKALLEEP 694 baker's yeast
Q5ZK03    612 QDLTQSLIMIQPILYAYSFH-GPPEPVLLDSSSILPDRILLMDTFFQIVIYLGETIAQWQKAGYQDMPEYENFKHLLQAP 690 chicken
Q4PE39    615 EDVNNSLIMIQPTLMSYGFE-GPPQPVLLDSVSIRPDVVLLLDTFFHILIFHGETVAQWRKAGYQDQEGYENFKEVLENP 693 Ustilago maydis 521
Q9C284    615 EDVSNSLIMIQPTLDSYTFDqEGGVPVLLDSTSIQPTHILLLDTFFHILIFHGETIAEWRKAGYQDQEGYENFAALLEQP 694 Neurospora crassa
Q54T59    597 ENVSNSLIMIQPTLEKYSFS-GPPHPEVLSASSISIDSILLLDTFFHVLIFHGETIAQWRKAGYDKDPQHQNFRDLLQAP 675 Dictyostelium disc...
NP_730978 618 EDLTQSLIMIQPILYSYSFN-GPPEPVLLDTASIQADRILLMDTFFQILIYHGETIAQWRALKYQDMPEYENFKQLLQAP 696 fruit fly
NP_507877 668 ENVLESTTMIQPVLFSYSFN-GPPEPVLLDTSSILADRILLMDDYFHVLIYHGQTIAQWRKQNFHENPQYATFKQLLEAP 746 nematode
NP_563741 631 ENISNAAVMIQPSLTTYSFN-SLPQPALLDVASIGADRILLLDSYISVVVFHGMTIAQWRNLGYQNQPEHQAFAQLLEAP 709 thale cress
NP_568626 644 EGVVNSIIMIQPTLLRYSFD-GPPVPVLLDIRSVTPDVILLFDSYFYVVIHHGSKIAQWRKLEYHKDPSHETFRNLLEAP 722 thale cress

Feature 1                                #              
2NUT_A    693 VDDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNN 734 human
1M2O_A    695 KLEAAELLVDRFPLPRFIDTEAGGSQARFLLSKLNPSDNYQD 736 baker's yeast
Q5ZK03    691 LDDAQEILQTRFPMPRYVHTEHGGSQARFLLSKVNPSQTHNN 732 chicken
Q4PE39    694 RADAQDLLADRFPIPRYIVCDQNGSQARFLLSKLNPSTTHMS 735 Ustilago maydis 521
Q9C284    695 KEDARDLITDRFPLPRFIVCDQGGSQARFLLSKLNPSTTHTS 736 Neurospora crassa
Q54T59    676 RDDAAHILKERFPYPRYIVCDQHSGEARFLLATIDPNITHTS 717 Dictyostelium discoideum AX4
NP_730978 697 VDDAQEILQTRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNN 738 fruit fly
NP_507877 747 VADATSILQERFPMPRYIVTEHEGSQARFLLSKVNPSLTHNN 788 nematode
NP_563741 710 QEDAQMIIRDRFPVPRLVVCDQHGSQARFLLAKLNPSATYNN 751 thale cress
NP_568626 723 EIDAAQLVTDRIPMPRIVRCDQHGSQARFLLAKLNPSVTQKT 764 thale cress

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap