Conserved Protein Domain Family
LOTUS_3_TDRD5
?
cd09976: LOTUS_3_TDRD5 
The third LOTUS domain on Tudor-containing protein 5 (TDRD5)
The third LOTUS domain on Tudor-containing protein 5 (TDRD5): TDRD5 contains three N-terminal LOTUS domains and a C-terminal Tudor domain. It belongs to the evolutionary conserved Tudor domain-containing protein (TDRD) family involved in germ cell development. In mice TDRD5 is a component of the intermitochondrial cements (IMCs) and the chromatoid bodies (CBs), which are cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis. The exact molecular function of LOTUS domain on TDRD5 remains to be identified. Its occurrence in proteins associated with RNA metabolism suggests that it might be involved in RNA binding function. The presence of several basic residues and RNA fold recognition motifs support this hypothesis. The RNA binding function might be the first step of regulating mRNA translation or localization.
Links
?
Statistics
?
PSSM-Id: 193590
Aligned: 6 rows
Threshold Bit Score: 109.817
Created: 8-Mar-2011
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
NP_001038315  289 SQELKEKLRKVVAENGn--gISIHNLPTEYQRMHGEELPvsqcGFLSVTEMVGALSDTLAIqrgtdeSESHWMVVEFK 364  zebrafish
A0JM98        379 SDALRMDIQHVVNQHSd--gLKISQLPTVFKSFTGKDLPfkelGFMSVMELVGSLGDILCVes--tvDGKDWKLFDAK 452  western clawed ...
Q5VCS6        292 DPELKRKIQFVVSKFPq--gLFISKLLGEFELTFKEQLSpkqlGFLNVTELVGALSDILRVef--seERQDLLVFDAD 365  house mouse
XP_003130391  213 HRDLAQALLDAEENAKlhslNLSNLINSVVNVIFKEPLSpkklGFLNVTELVGSLSDILHVef--reGEQDLLVFDAD 288  pig
XP_783924     371 DKQLCGEIREVLEHHPn--gLFAASLPTEYKALTKKELPlvsiGFYSVVELVSSIPEIVAIer--qkKNSDWILFDAR 444  purple urchin
XP_001634319  311 SRMLREEIAKILNMRPn--gVWSARLPVEYKKLFKKELVvrqhGFTSVIELADAIPDIVRIhr--ptKTGDWLLLGNK 384  starlet sea ane...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap