Conserved Protein Domain Family
LIM2_FBLP-1
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cd09372: LIM2_FBLP-1 
The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1)
The second LIM domain of the filamin-binding LIM protein-1 (FBLP-1): Fblp-1 contains a proline-rich domain near its N terminus and two LIM domains at its C terminus. FBLP-1 mRNA was detected in a variety of tissues and cells including platelets and endothelial cells. FBLP-1 binds to Filamins. The association between filamin B and FBLP-1 may play an unknown role in cytoskeletal function, cell adhesion, and cell motility. As in other LIM domains, this domain family is 50-60 amino acids in size and share two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein.
Links
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Statistics
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PSSM-Id: 188758
Aligned: 8 rows
Threshold Bit Score: 86.7091
Created: 18-Oct-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Zn binding site
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The Zn binding residues of LIM domain are highly conserved.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #                #  #  #  #                  #  # 
NP_001072272 252 CAKCQALITQHIVRAmgNGYHPECFTCVVCHRRIADESFAVDEynDVYCAdDY 304 western clawed frog
CAX13658     165 CWACGDVIKDHVIRAleRAYHPPCFVCTTCRQPIGEQRFAQGEvgEVYCLqDY 217 zebrafish
NP_001108306 254 CAKCQLLITQHIVRAmgSGYHPECFTCVVCQRRIADESFAVDEfnDVFCAeDY 306 African clawed frog
XP_417617    201 CAKCQGLITERIVRAlgKGFHPGCFACAACGRAIGAESFAVDEqgKVYCVaDF 253 chicken
XP_001377399 201 CGRCQAVVLEHVIRAlgQTFHPDCFMCVVCSRRIGDESFALDDqnEVYCLdDF 253 gray short-tailed opossum
Q71FD7       245 CGKCGEVVQEHVIRAlgKAFHPPCFTCVTCARCISDESFALDSqnQVYCVaDF 297 house mouse
NP_001019386 243 CGKCGEVVRDHIIRAlgQAFHPSCFTCVTCARCIGDESFALGSqnEVYCLdDF 295 human
XP_002189320 205 CAKCQGLITEHIVHAlgKGYHPSCFSCAACGRAIGTESFAVDKqgDVYCVpDY 257 zebra finch

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