1A5R,1EUV


Conserved Protein Domain Family
Sumo
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cd01763: Sumo (this model, PSSM-Id:176359 is obsolete and has been replaced by 340462)
Click on image for an interactive view with Cn3D
Small ubiquitin-related modifier (SUMO)
Small ubiquitin-related modifier (SUMO) proteins are conjugated to numerous intracellular targets and serve to modulate protein interaction, localization, activity or stability. SUMO (also known as "Smt3" and "sentrin" in other organisms) is linked to several different pathways, including nucleocytoplasmic transport. Attachment of SUMO to targets proteins is stimulated by PIAS (Protein inhibitor of activated STATs) proteins which serve as E3-like ligases.
Links
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Statistics
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PSSM-Id: 176359
Aligned: 24 rows
Threshold Bit Score: 116.948
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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Ulp1 - Smt3hydrophobic
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:Ulp1 - Smt3 interaction site
Evidence:
  • Structure:1EUV_B (Ulp1 Protease) binds Smt3 (1EUV_A)
    - View structure with Cn3D
  • Comment:intermolecular contacts determined using 3.5A distance
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                          #  ### # #  #     #       #
1A5R       13 EDLGDKKEGEYIKLKVIgq-dsSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIE 91  human
1EUV_B      1 EVKPEVKPETHINLKVSdg--sSEIFFKIKKTTPLRRLMEAFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIE 78  baker's yeast
NP_703403  12 GSSPVNNQGEHIQVKVRsp-dgAEVFFKIKRKTKLEKLMEVYCNRLGQSMEAVRFLYDGDRIHGDNTPEQLGIEDGDVID 90  Plasmodium falcipa...
O13351     25 SQQDVKPSTEHINLKVVgq-dnNEVFFKIKKTTEFSKLMKIYCARQGKSMNSLRFLVDGERIRPDQTPAELDMEDGDQIE 103 fission yeast
AAP34642    2 EETKDQKPNEHLNLKVKsq-dgNEVFFKVKKTTPFKRLMEAYCQKVGAEKSSVRFLFDGDRISGDQTPADLDMQDEDEID 80  Bigelowiella natans
EAA39359   15 EAEVKPEQAQKIMIKVSde-heNAICFKVKMTTALSKVFDAYCSKNSLQRGDVRFYFNGARVSDTATPKSLDMAENDIIE 93  Giardia lamblia AT...
T00792    289 SRSPETSPHMKVTLKVKnq-qgAEDLYKIGTHAHLKKLMSAYCTKRNLDYSSVRFVYNGREIKARQTPAQLHMEEEDEIC 367 thale cress
NP_200328   7 DKPIDQEQEAHVILKVKsq-dgDEVLFKNKKSAPLKKLMYVYCDRRGLKLDAFAFIFNGARIGGLETPDELDMEDGDVID 85  thale cress
EAK89568   32 GTGGASDDSQYVTVKVRsp-dgEQVLYRIKKKTRLQKLMNSFCQRTGQNEQSIRFLFEGERLRPEMTAEDAGLQEGDLID 110 Cryptosporidium pa...
NP_199682  17 QKRKVVSDPTHVTLKVKgqdeeDFRVFWVRRNAKLLKMMELYTKMRGIEWNTFRFLFDGSRIREYHTPDELERKDGDEID 96  thale cress

Feature 1      ###    
1A5R       92 VYQEQTGG 99  human
1EUV_B     79 AHREQIGG 86  baker's yeast
NP_703403  91 AMVQQTGG 98  Plasmodium falciparum 3D7
O13351    104 AVLEQLGG 111 fission yeast
AAP34642   81 AMVQQTGG 88  Bigelowiella natans
EAA39359   94 VMRNQIGG 101 Giardia lamblia ATCC 50803
T00792    368 MVMELGGG 375 thale cress
NP_200328  86 ACRAMSGG 93  thale cress
EAK89568  111 AMISQVGG 118 Cryptosporidium parvum
NP_199682  97 AMLCQQSG 104 thale cress

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