2DF3,1URL


Conserved Protein Domain Family
Ig_Siglec_N
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cd05712: Ig_Siglec_N (this model, PSSM-Id:143189 is obsolete and has been replaced by 409377)
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Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
Ig_Siglec_N: immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.
Links
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Statistics
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PSSM-Id: 143189
Aligned: 7 rows
Threshold Bit Score: 172.215
Created: 17-Sep-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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ligand binding
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2DF3_A; human siglec-7 bound with DSLc4, a sialoside; contacts based on 3.5 A distance.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
2DF3_A         3 YSLTMQssVTVQEGMCVHVRCSFsypv---tdsdPVHGYWFRASwk----aPVATNNPawaVQEETRDRFHLLGdpqtkn 75  human
1URL_A         2 WGVSSPknVQGLSGSCLLIPCIFsypad-vpvsnGITAIWYYDYsgk--rqVVIHSGDpklVDKRFRGRAELMGnmdhkv 78  house mouse
NP_001088138  18 FKIEAPvnVIVQRGLCVLIPCNFtvgpk-ynltkDAIGIWYKGHpn----dPVAASTNssqFPDTTNGRFIFTGkvsagd 92  African clawed ...
CAF33196      22 WNVWMPrdISAMTNSCVVIPCSFtypsg-irpyrGVHGIWYFGHpypqlfpPVVLKSRtdiVHESYKGRTKLLGdltqkn 100 zebrafish
AAH29896      21 YELQVQksVTVQEGLCVLVPCSFsypwrswysspPLYVYWFRDGeipyyaeVVATNNPdrrVKPETQGRFRLLGdvqkkn 100 human
EAW52587      22 YSLQVQrqVPVPEGLCVIVSCNLsyprdgwdestAAYGYWFKGRtspktgaPVATNNQsreVEMSTRDRFQLTGdpgkgs 101 human
AAI22605      22 WGAWMPssISAFEGTCVSIPCRFsfpde--lrpaVVHGVWYFNSpypknypPVVFKSRtqvVHESFQGRSRLLGdlglrn 99  cattle

Feature 1                          #        ##           
2DF3_A        76 CTLSIRDarmsDAGRYFFRMEkgn-ikWNYKYDQLSVNVT 114 human
1URL_A        79 CNLLLKDlkpeDSGTYNFRFEisdsnrWLDVKGTTVTVTT 118 house mouse
NP_001088138  93 CSFSISDaqpgDAAKYRFRLEdrdplkFNYLHIQPSVSVT 132 African clawed frog
CAF33196     101 CTLLISNigveHSGKYYFRADlgganiYTFPDFTKLQVLD 140 zebrafish
AAH29896     101 CSLSIGDarmeDTGSYFFRVErgrdvkYSYQQNKLNLEVT 140 human
EAW52587     102 CSLVIRDaqreDEAWYFFRVErgsrvrHSFLSNAFFLKVT 141 human
AAI22605     100 CTLLLSNlspeLGGKYYFRGDlggynqYTFSEHSVLDIIN 139 cattle

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