Conserved Protein Domain Family
PBP1_Pheromone_receptor
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cd06365: PBP1_Pheromone_receptor (this model, PSSM-Id:107360 is obsolete and has been replaced by 380588)
Ligand-binding domain of the V2R phermone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
Ligand-binding domain of the V2R phermone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.
Links
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Statistics
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PSSM-Id: 107360
Aligned: 29 rows
Threshold Bit Score: 499.075
Created: 29-May-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
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putativeputative
Feature 1:putative ligand-binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the Rattus norvegicus mGluR subtype I structure complexed with glutamate.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                 #                                       
NP_787950      38 GTVVIGAFFpilhnslvrtttdwk--yfpmdsdnyfgmsgRNYQLVLAMLFAINEINLNSHILPNTSLGLEIYNLPaiGR 115  house mouse
NP_001093063   41 GDLVIGGFFplylmavksftgae----hpqkacnphqwlhKNYQQVLALMFAVEEINRDSSLLPNTTLGFHIYNSYhsDA 116  gray short-ta...
XP_001381756   29 GDLVVGGFFpliknkmtkfgywkmfwihpkynmkdyrwlqKHYYQVLALMFAVEEVNRNPNLLPNRTLGFHIYNAYhnDD 108  gray short-ta...
NP_001093025   39 GDLILGGFFplfmykfsqyttwkmfqrhpqyilkgylrlpKHYYQVLALMFAVEEINKNPNLLPNVTLGFHIYNVYhnDE 118  gray short-ta...
NP_001093015    9 GDLVIGGFLplyalrvnkvtraadfmrrpnedcrsyqwlhKNFQQAMTIRFAVEEINRDPVLLPNVSLGFQVYNAYhsDE 88   gray short-ta...
XP_001520444  151 GDLVITGMLslqtlttfpdpifqs--vskhemenydywvhKDFQHFLALLFAVEEINKDPSLLPNVSLGFHVHEIYhhAN 228  platypus
XP_001509732   12 GDLVIGGLLalnvfegnlpsfkk----hpfwfdkgfarvpKHNQHVLALVFAVEQINKDPSLLPNFSLGFHLYDTLfrER 87   platypus
XP_001510056   43 GDVVIGGLFsldvilsnwgesenf-keeppdiddvteyftKHYQHLMALVFAVEEINKDPNLLPNISLGFHLFNVHflGL 121  platypus
Q6TAC4         37 ADFVIGGLFslrvtdgdtfisrsgvedtshiaeyvfadliKYYQHILAMVFAIEKINKDPNILFNKSLGFFLFNVNfiEM 116  house mouse
EDK99728      548 WLGTYPPFPdvdmhsefgqiilwy-negstlafycvlgylGFLASLSLFIAFLKKINKDPNILFNMSLGFYLFNVDfiVM 626  house mouse

Feature 1                                                                       ##                
NP_787950     116 NIFRTVFSWLtglssviPNYTCrk--esNSAATLTGVswkt---setIWTILDLYKFPQLTFGPFDpvqidrnqFQSLYQ 190  house mouse
NP_001093063  117 RTLESSLRWLsgqgqtiPNYSCer--qdKSLAVIGGAtsal---svqMGTLLELYRFPQVSYGPFDtalsdkdqFPSLYQ 191  gray short-ta...
XP_001381756  109 KILESSLMWLsgqaqtiPNYNCer--qaKSVVVIGGAnsal---tvsMGTLLELYKFPQISYGLFDpllndpaqFPSVYQ 183  gray short-ta...
NP_001093025  119 GTLESSLMWLsgkgptiPNYNCer--qdNSVVVIGGGtsem---tvsMGTLLELYKFPQVTYGLFDpllsdpvqFPSVYQ 193  gray short-ta...
NP_001093015   89 RTLESSLQWLtgesqpvPNYSCre--qdKIVAIIGGAtsalsvqmgtLLELYNFPQVGDLSFGPFDliltdkvqFPSLYQ 166  gray short-ta...
XP_001520444  229 RAMEGALMGLsgveqtvPNYSCgk--qeKSMAVIGGAtsal---siaMATILGLYRLPQITYGPFDpvlsdkirFPSLYQ 303  platypus
XP_001509732   88 LAVEQSLMLLsgpgrtvPNYSCee--rgKLVAVIGGIkstl---siaMANVLGFHKFPQITYGPFDgtlrdsgqFPSLYQ 162  platypus
XP_001510056  122 IAAESSMSLLsgragwvPNYNCeperwdKLLAVIGGMstav---smtSSWLLGLHKLPQICYGPEDptlrdkaqFPSLYQ 198  platypus
Q6TAC4        117 KAAEGSMALLsgesppiPNYSCrpektdKLVAVIGGIstsi---siqISRVLSLYNVPQISYAPFDqilgtrvqLQSPYQ 193  house mouse
EDK99728      627 KATESSMVLFsgerppiPNYSCrpektnKLVAVIGGYsiai---taeISQVLSLYNVPQISYAPFDqslasrvqLQTPYQ 703  house mouse

Feature 1                                                                                         
NP_787950     191 VAPKDTALLSGIASLMLHFNWNWVGLLIPDDqrGAQFLSDFRKELDKTkICIAFVKTVLYLGetllrliSQDHIHIIESS 270  house mouse
NP_001093063  192 MAPQDSSLHLGIVQMLLHFGWTWVGLVVPDDmrGEKFLSDMREEMRRNkACVAFIEKIPVSErcheesqVAFMPRIMASS 271  gray short-ta...
XP_001381756  184 MATSDTSLSLGMVRLMVHFEWTWVGLVTSDDaiGDKFLRDMKEEMVRNyICVAITQKISIGQsmdidthRLFLWKIFKSR 263  gray short-ta...
NP_001093025  194 MAPRDTSLPLAMVRLMLYFKWTWVGLVASDDsrSEKFLRDLQEEMVRNdVCVAFMLKFATGDkmsipsfDNFLQKIYSST 273  gray short-ta...
NP_001093015  167 MAPKDYSLQQGVARLLAYFKWTWVGLVTTDDlrGEEFLREMTGRMEKYgICAAFTEKIPVSEriheeskVNFMPRIMESS 246  gray short-ta...
XP_001520444  304 VAPRISSLPRMIVQLMVHFGWTWVGLVVSDDmrGESFLSDVTGEMVRNgVCAAFTEKIPSGRfst-ykvQHFYARIMASS 382  platypus
XP_001509732  163 MAPRDTAQQRGIVRLLVHFGWTWVSLVISNNvqGETFARDLMGEMDRHgVCVAFTEQIPETKyygtweaRLFHHKMNTIL 242  platypus
XP_001510056  199 ISTSSPNLPSGMIRLMKHFHWVWIGILVTDDirGETFATVLTEEMAKNgICVAYVKRVNNYFsksvsslEYNHREITTSS 278  platypus
Q6TAC4        194 FSMHTAALYQGIVQLLLYFTWIWVGLVVPDDmrGELYLRDITKEMISHgICFAFAEKVTEYSsmdtvnwKHFMERLTLTP 273  house mouse
EDK99728      704 FPVHTTALYQGIIQLLLYFTWVWVGLVVPDDsrGELFIMEFIEEMINHrLCVAFAIRSPQFPfenqgkwEIFCEKIPLTR 783  house mouse

Feature 1                                                                                         
NP_787950     271 tadVIVIYGPtsiLLTLIENTYRTyn--kkKIWVMSTKWFcpn--lelYNMLELTHGALIFSPhykeIVGFKKFMLEATP 346  house mouse
NP_001093063  272 a-kVIIIHGDtdsLMILRYSQPPSis--lwKIWIITSHWDvtm--rphNHDSDTFLGALIFSHqtseIPGFKSFLKAVTP 346  gray short-ta...
XP_001381756  264 v-nVIVIYGDidsLLSVKFREEPYfl--pkILWITTRDSDitk--kpgSVYFDNFHGALIFSTktsqMPGFQHFLKTINP 338  gray short-ta...
NP_001093025  274 a-kIIVIYIDsdsFQSQVFDSDAHkhilihKMWITNSYWNiar--spsRIYSNNFHGALIFSDqtskTFGFKPFLKPINP 350  gray short-ta...
NP_001093015  247 a-rAVVIHGDtdsLMVLRHSQIPFip--myKIWITTSHWDitm--rpkYVDNYNFYGALTFTYltseVPGFKSFLKTVHP 321  gray short-ta...
XP_001520444  383 t-nVIAAYGDaefLNLLRAVIEWFgl--skMVLITTYHWDftls-mmhEPNNNHFHGTLTMASfakeVPGFRDFLRTIRP 458  platypus
XP_001509732  243 v-nVVIVHGDidsLIMFKWVIGWAei--wgKVWITTAHWDisvs-nayNTYQNSFCGSLSFSIhtdeITGFEDFVREASP 318  platypus
XP_001510056  279 a-gVVADYGDtfsLLAVVYRMDLNpi--ygKVWVTTSDWDlta--ntyMKDNTFFQGSLLFSLhrkeIPGFRDFEQILNP 353  platypus
Q6TAC4        274 ---VIITVGDthsLLRIVYFVIFYnl--sgNVWITTSDWYittlpfeqNLIYTHFGGGLSFSFhmdeILGFKDFLRSVQP 348  house mouse
EDK99728      784 ---VIIAVGDtydTIWIFYIITLYip--ygKIWITNSDWFttlp-sqlNFIYKYFSGGLLVLHkmdeILGFKDFLRNVQP 857  house mouse

Feature 1                                                               #                         
NP_787950     347 IKYpeDIFLHLLWYWHFNCsflhseckifenc--lqnaslellpgniFTMTMTeESYNVYNAVYAVAHSLHeetlsqiqf 424  house mouse
NP_001093063  347 AKYpgDIFLKSFWVSAFECpdepdkleredcp---lnaslemlplhyFDMTMLsLSYYVYSAVYAVAWALHemletrpev 423  gray short-ta...
XP_001381756  339 LNYpdDIFLEQFWVTTFGCtsnhrkgdgsvcs---qnasfdtlslsyLDEIMSyQSYTVYNAVYAVAWALHemllvrsei 415  gray short-ta...
NP_001093025  351 AKYpeDILHQNLWDSVFKCtsnkkkgvgdvcs---tnvsldeshwsyLDMTMSdQSYTVYKAVYAVAWALHemflrrsem 427  gray short-ta...
NP_001093015  322 SKDpkDTVLRDFWFSAFQCqsksknldleqct---pnetleslpiylFDTTMSgLSYTIYNAVYAVAWALHeellrkset 398  gray short-ta...
XP_001520444  459 AKYpdSIILKKFWESAFDCalsfseiygrkcs---enaslemlpmhyFSLMMSaPSYSVYNAVYAVAHGFQelllsrsdv 535  platypus
XP_001509732  319 SKYpnDVFLQQFWEAEQGCflslrqmgrkrtgvcmgnesfdrlpqfdLDLQLSgLKYTLYSAVYAVARVLHemllsrtea 398  platypus
XP_001510056  354 RKYplDAFLLKFWQWAFECqyldsflsmtcd----fndtlenrpldlWDMSLSaQSYSVYSAVYAIAHALHqeiwaeriw 429  platypus
Q6TAC4        349 RKYphDIFIRHVWSSLFGCphyyqhrlwdlsqc-epngslstrplhaWDMNTSpYSYKVYAAVYAIAQALHeelslrveg 427  house mouse
EDK99728      858 RKYphNIFIQDMWSILFECpyfyrqkvrvlsqc-epngslstqplhvWDMNTSpSSYKVHAAVYAIAQALReelsvrveg 936  house mouse

Feature 1                                                                                         
NP_787950     425 qpqanidrtllfpwqlhpFLKKIQVknsvgdHVVLDWkRKADPEYDITNIwnfptglslLVKVGTFvpsapkgeQLSMSE 504  house mouse
NP_001093063  424 eserderslapqnwqlhsSLRNTDFnntaenLVVLDDeKNPVAKYDIMNFalksnydevLVKVGQFvpqdplghDLTICE 503  gray short-ta...
XP_001381756  416 etkihggnqiihpwklhsFLKNIQFnnsagnQVVLEKkRKSMTNYDILNYvtfpndtdvLVKVGEFipqtppvqDFTIQE 495  gray short-ta...
NP_001093025  428 esniqedtwatyprklhsFLKNIQFn-----NSDGKQrQNSMANYDILNHvtfanktevLVKVGEFihqaplgqDFTIHE 502  gray short-ta...
NP_001093015  399 apeeagesgvphpwqlhsFLKDIQFhnsagdQVFMDEkRRSEAQYDIRNYvtslndtefLVKVGQFlpntqpgqDFIMHE 478  gray short-ta...
XP_001520444  536 kswgnedrlvpppwqfheFLRNVQFdnpagqLVILDEnSRSSAKFDILNFvifpngtgeFVKVGEVdpqatpnqDVSVNE 615  platypus
XP_001509732  399 evsetgdavifpprqlysFLRRPKLkitaggEWNFDRnNPSVVSYDILNFiqvgfenftRVKVGEFnpqsflgnDLTINE 478  platypus
XP_001510056  430 r--------hqemvqlhqFLKNTLShtgtgeQIHLVDpSWVTTKFDILNYqilengskgYVKVGEFmplapagqDFAISD 501  platypus
Q6TAC4        428 dssnkcllqaplpwklhpFLQKGQLgrs-tnEENTVNkEVSAIKLDIFNYqslqsgteaHVKVGEFvfdshsvqHLSLND 506  house mouse
EDK99728      937 dsfdkvllwapvpwklhpFLQNGQFvrs-ssEENIVNkEGSATKLDIFNYqslmsgtkaHVKVGEFvfkshsvqHLSLNE 1015 house mouse

Feature 1              
NP_787950     505 YMISW 509  house mouse
NP_001093063  504 KNIYN 508  gray short-tailed opossum
XP_001381756  496 KAIVW 500  gray short-tailed opossum
NP_001093025  503 KAMVW 507  gray short-tailed opossum
NP_001093015  479 EDINW 483  gray short-tailed opossum
XP_001520444  616 AMIVW 620  platypus
XP_001509732  479 EAIVW 483  platypus
XP_001510056  502 EKIMW 506  platypus
Q6TAC4        507 KIITW 511  house mouse
EDK99728     1016 ELISW 1020 house mouse

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