Conserved Protein Domain Family
PBP1_GPC6A_like
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cd06361: PBP1_GPC6A_like (this model, PSSM-Id:107356 is obsolete and has been replaced by 380584)
Ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor
This family includes the ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor, and its fish homolog, the 5.24 chemoreceptor. GPRC6A is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses.
Links
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Statistics
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PSSM-Id: 107356
Aligned: 6 rows
Threshold Bit Score: 688.146
Created: 6-Jun-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
Download Cn3D
 
putativeputative
Feature 1:putative ligand-binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the Rattus norvegicus mGluR subtype I complexed with glutamate
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                         #                                           
Q5T6X5     37 IIGGLFAIHEKMlssedsp----rrpqiqECVGFEISVFLQTLAMIHSIEMInnst--llpgVKLGYEIYDTCtevTVAM 110  human
XP_426177  37 IIGGLFAVHSEMlqpeehp----ikpviqNCAGFEIQIFLQTLAMIHAIEMInnst--llsgVTLGYEIYDTCaevTKAM 110  chicken
NP_683766  37 IIGGLFAIHEKMlssedsp----rrpqiqECVGFEISVFLQTLAMIHSIEMInnst--llpgVKLGYEIYDTCtevTVAM 110  human
Q70VB1     37 MIGGLFAIHEKMlssddhp----rqpqiqKCVGFEISVFLQTLAMIHSIEMInnss--llsgVKLGYEIYDTCtevTAAM 110  Norway rat
Q9PW88     38 IIGGLFPIHEAAeavnftglnsfssfqhpVCNRYYTKGLNQALAMIHAVEMAnqspmlsslnLTLGYRIYDTCsdvTTAL 117  goldfish
Q5U9X3     36 IIGGLFPIHEAVvpvnytgnnsisapehpDCIRFYTKGLNQALAMINAVEMAnkspmlsslnITLGYRIYDTCsdvTTAL 115  zebrafish

Feature 1                                                                ##                   
Q5T6X5    111 AATLRFLSKFNCSREtvefkCDYSSYMPRVKAVIGSGySEITMAVSRMLNLQLMPQVGYESTAeILSDKIRFPSFLRTVP 190  human
XP_426177 111 ASALRFLSKSNTSKDivefkCNYSDYVPRIKAVTGASySEVSMAVSRLLALQLIPQVSPASSAeILSDKIRFPSFLRTIP 190  chicken
NP_683766 111 AATLRFLSKFNCSREtvefkCDYSSYMPRVKAVIGSGySEITMAVSRMLNLQLMPQVGYESTAeILSDKIRFPSFLRTVP 190  human
Q70VB1    111 AATLRFLSKFNCSREtvifqCDYSSYVPRVKAIIGAGySEISMAVSRMLNLQLMPQVSYESTAeILSDKIRFPSFLRTVP 190  Norway rat
Q9PW88    118 WAVQDLTRPYSYCDSq----TNSSQPVQPIMAVIGPSsSEISIAVARELNLLMIPQISYASTAtILSDKSRFPAFMRTVP 193  goldfish
Q5U9X3    116 RAVHDIMRPFSDCESp----EDSSQPVQPIMAVIGTTsSEISIAVARDLNLQMIPQISYASTAtILSDKSRFPAFMRTVP 191  zebrafish

Feature 1                                                                                     
Q5T6X5    191 SDFHQIKAMAHLIQksgWNWIGIITTDDDYGRLALNTFIIQAEANnVCIAFKEVLPAFLSDntievrINRTLKKIILEa- 269  human
XP_426177 191 SDFHQTRAMAHLICesgWNWIGVIATDDDNGRFALESFGVQAMANsVCIAFKEMLPAYLSDntfhtkVDRAVEKIVKEt- 269  chicken
NP_683766 191 SDFHQIKAMAHLIQksgWNWIGIITTDDDYGRLALNTFIIQAEANnVCIAFKEVLPAFLSDntievrINRTLKKIILEa- 269  human
Q70VB1    191 SDFYQTKAMAHLIRqsgWNWVGAITTDDDYGRLALNTFAIQAAENnVCIAFKEVLPAFLSDntievrINQTLEKIIAEa- 269  Norway rat
Q9PW88    194 NDEYQTHAMVQLLKdnkWTWVGIIITDGDYGRSAMESFVKHTEREgICVAFKVILPDSLADeqklniHINETVDIIEKnt 273  goldfish
Q5U9X3    192 SDEYQTCAMAKLLKsnkWSWVGIIITDGDYGRSALEGFIQHTETEgICIAFKAILPDSLADqqklntDIENTLNIIENnp 271  zebrafish

Feature 1                                                                                     
Q5T6X5    270 qVNVIVVFlrqfhVFDLFNKAIEMni--nKMWIASDNWSTatkittiPNVKKIGKVVGFAFrrGNISSFHSFLQNLhllp 347  human
XP_426177 270 rVNVIVVFmrqfhVLKLFKKAIERnv--kKIWIASDNWSTavkistmPNIRKLGTVVGFGFknKDLSTFQDFLRNLhdrp 347  chicken
NP_683766 270 qVNVIVVFlrqfhVFDLFNKAIEMni--nKMWIASDNWSTatkittiPNVKKIGKVVGFAFrrGNISSFHSFLQNLhllp 347  human
Q70VB1    270 qVNVIVVFlrkfhVFNLFNKAIERki--sKIWIASDNWSTaakiitiPNVKKLGKVVGFTFrrGNMSSFHSFLQTLhmyp 347  Norway rat
Q9PW88    274 kVNVVVSFakssqMKLLYEGLRSRnvpknKVWVASDNWSTsknilkdVNLSDIGNILGFTFksGNVTAFLQYLKDLkfgs 353  goldfish
Q5U9X3    272 kVRVVISFakssqMQLLFKGLQSRnisnnMVWVASDNWSTakhilndGSITDIGKVLGFTFksGNFTSFHQYLKNLqfes 351  zebrafish

Feature 1                                                                        #            
Q5T6X5    348 sdshkllheyamhlsacayvkdtdlsqcifnhsqrtlaykankaiernfvmrndflwdyaepgLIHSIQLAVFALGYAIR 427  human
XP_426177 348 tennkflleyimllsvcahldnydfqmc---issqsqydlmqnvenkhqiwrddflnaniepgFIHSTILAVYAIAHAIK 424  chicken
NP_683766 348 sdshkllheyamhlsacayvkdtdlsqcifnhsqrtlaykankaiernfvmrndflwdyaepgLIHSIQLAVFALGYAIR 427  human
Q70VB1    348 sdnnkplhefamlfsackhikdgdlsqcisnysqatwtydttktiethlfkrndflwhytepgLIHSIQLAVLALGHAIR 427  Norway rat
Q9PW88    354 eakmnnsfleeflklp----------------------------eignaanavqeqiknthldMVFSVQMAVSAIAKAVV 405  goldfish
Q5U9X3    352 edemnnsflkeflkl-----------------------------nagnasntvlelmkstnldKIFSIEMAVTAVANAVA 402  zebrafish

Feature 1                                                                                     
Q5T6X5    428 DLCQArdcqnpnafqPWELLGVLKNVTFtdgwnSFHFDAHGDLNTGYDVVLWkein-ghmtVTKMAEYdlq--ndvFIIP 504  human
XP_426177 425 GQCKDrncknpsafaPWELLEELKKVTIidddkEIKFDSKGDLSSGYDVLLWkevd-grmeITTMAEYdpe--ngyFIFE 501  chicken
NP_683766 428 DLCQArdcqnpnafqPWELLGVLKNVTFtdgwnSFHFDAHGDLNTGYDVVLWkein-ghmtVTKMAEYdlq--ndvFIIP 504  human
Q70VB1    428 DLCQDrdcqkpnafqPWELLAVLKNVTFtdgknSFHFDAHGDLNTGYEVVLWketn-glmtVTKMAEYdlq--hdvFITT 504  Norway rat
Q9PW88    406 ELCVErqcktpsaiqPWELLKQLRNVTFekegvMYNFDANGDINLGYDVCLWddde--sekNDIIAEYyps--nssFTFT 481  goldfish
Q5U9X3    403 KLCAErqcqdstalqPWELLRQLRSITFenggeMYKFDANGDINLGYDLFLWegdqsdehaDDIIAEYdptkggfhYIHN 482  zebrafish

Feature 1       
Q5T6X5    505 DQ 506  human
XP_426177 502 DE 503  chicken
NP_683766 505 DQ 506  human
Q70VB1    505 NQ 506  Norway rat
Q9PW88    482 RK 483  goldfish
Q5U9X3    483 DL 484  zebrafish

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